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Hi all, I caught HSV-2 over 4 years ago. It was pretty typical in the beginning, with a major outbreak first and further ones that followed. However, I was able to keep them under control with Acyclovir 400mg/day suppressive therapy and 1000mg a day during outbreaks. In the past year or so, it has been getting worse and worse. The outbreaks started on my penis but later I started getting them on my buttocks too. In the last few months, they have been present only on my penis but NON-STOP. As an outbreak clears an new one will start within a few days. I can feel swollen lymph nodes on my groin and I'm constantly lethargic with a fewer-like feeling. I have had a non-stop outbreak for the last 2 months! Lifestyle: Since 16 years old I eat very healthy (high protein, complex carbs, vegetables), excercise 4 times a week (fitness/bodybuilding) and sleep 8-9 hours per week. I don't drink alcohol, but do drink coffee daily. Apart of HSV-2 and being on HRT I am very healthy. Current daily drug / supplement stack to combat the virus: Acyclovir 1200mg / 3200mg during outbreaks L-Lysine 2000mg / 4000mg during outbreaks Zinc 50mg Vitamin C 1000mg Multivitamin Others I have tried without success: Valacyclovir 1000mg/d, CBD oil Other unrelated drugs and supplements I take that could have effects (since a long time): Testosterone injections (I'm on HRT, due to testicular cancer I had at 18 years old) Arimidex (control Estradiol levels) Finasteride 0.5mg (reduce hairloss) Fish oil Whey protein L-glutamine 5-HTP (mood/sleep boost) I have recently started researching the possible effects of the testosterone replacement therapy and the effects of hormonal balance on HSV-2 outbreaks. I found research indicating that increased Estradiol/Progesterone levels can trigger outbreaks (can share if anyone is interested). I got labs done and found the levels were elevated, so I increased my Arimidex dosage without success. I have not yet tried the following supplements: Coconut oil, Probiotics, Vitamin B-12, MonoLaurin. Any advice what to do next :(? I'm feeling terrible for 90% of my life at the moment. When I visit a doctor / hospital they just prescribe me Acyclovir at a lower dosage I'm already taking.