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Found 13 results

  1. New article highlighting Keith Jerome's work in Men's Health Mag: https://www.menshealth.com/health/a26306319/herpes-cure-gene-editing/ I posted this on the donation thread, but I think it's also worthwhile to give it a separate thread. There are some interesting stats thrown out in this one. Some ofthe stats may have been lost in translation, in part due to sloppy journalisn, but it's still very good that Jerome's work is getting increasing attention, including from mainstream media. The point is that, Dr. Jerome's work has been progressing. If you've been follwing his work, this is good stuff. Please keep in mind that our community has been doing a fund raiser for Jerome's research. There's a thread about it on this site and the donation link is in my signature below. We've raised over $10,000 already. Please help us, this is a serious and new effort that is showing promise. They have essentially been able to partially cure mice by deleting a portion of their latent HSV. No other technology has been able to touch latent HSV--the source of the infection.
  2. Just goes to show you there's always someone working on something, even if they're not in the limelight of research. This also shows that experimental therapies, vaccines, etc can also be life saving like in this case... and they used a virus to edit the gene!
  3. Found a good article what do you think ? https://www.smithsonianmag.com/science-nature/can-we-gene-edit-herpes-away-180968551/
  4. https://www.wired.com/story/whats-next-for-crispr/amp
  5. I tried reaching out more than once to find out if they could assist with experimentation for hsv treatment or cure, but I haven't received a response. He has kids on his website but I don't know if any would be useful for hsv experiments. The company's owner is Josiah Zayner. Has anyone else tried and if so, we're you successful?
  6. His name is Josiah Zayner. He has a PhD in Biochemistry and used to work for NASA. Now he’s started his own company called ODIN as a biohacker and wants people to be able to modify their own genes without having to know the ins and outs of CRISPR and genetic modification. I think someone commented with another link about him, but this one actually has the live event where he explains his views and how having genome modification available to the public should be a thing because we have the right to make decisions for ourselves for our bodies instead of being reliant on the FDA, etc. I want to know what all of your views are on the matter after watching the video in this link. Do you think this could be one day available for treatment of something like HSV? https://www.buzzfeed.com/stephaniemlee/this-biohacker-wants-to-edit-his-own-dna?utm_term=.kuMnmk9Xo#.at630rBJk
  7. More CRISPR use for HIV...which can only lead to helping the people with HSV soon... “It’s like hiding a book in a stack at the library, and the book has instructions to build a nasty bomb. To get rid of that information, you need to get it back out of the library. We’ve never had the technology to do that inside the living cell until CRISPR came along. It’s the first efficient way to do that inside living cells.” http://m.sfgate.com/business/article/How-CRISPR-gene-editing-tech-can-fight-HIV-12294985.php How CRISPR gene-editing tech can fight HIV Oct 21, 2017 Researchers at UCSF have received a three-year, $1.6 million grant to advance their work using novel gene-editing technology to make human blood cells less susceptible to HIV infection. The grant, from biopharmaceutical giant Gilead Sciences, a global leader in sales of HIV treatments, will fund a team of scientists working to modify the DNA of a type of white blood cell to make them immune to HIV infection. The cells, called T cells, have long been a focus of researchers seeking to improve HIV treatments. T cells help the immune system fight many diseases, including some cancers and flu viruses. They play a unique role in HIV because the virus targets and destroys T cells, and HIV-positive patients whose T cells become too depleted by the virus will progress to AIDS... ...It is the first research initiative that Foster City’s Gilead, through its philanthropic program, has funded that involves using CRISPR as a tool in HIV cure-related research. While $1.6 million is not a huge amount, it comes with fewer restrictions than many government grants. The grant will fund a team of five researchers for three years.
  8. Oct 19, 2017 12:00pm The gene editing technology CRISPR-Cas9 has been heralded as a major advance in medical research. But it has one big limitation: It doesn’t work on cells that have stopped dividing, such as neurons in the brain. Now scientists at the Max Planck Florida Institute for Neuroscience say they’ve developed a tool that allows for precise genome editing of neurons. It capitalizes on a part of the CRISPR-Cas9 system called homology directed repair (HDR), which allows researchers to add, change or delete specific genes. Until now, HDR has only been feasible in cells that are dividing and proliferating in the body. To correct that shortcoming, the Max Planck team combined CRISPR-Cas9 with adeno-associated virus (AAV), a mild viral vector that’s often used for gene delivery. When they delivered the combo to mouse neurons, HDR occurred in an efficient manner, they reported. When they tested it in an aged mouse model of Alzheimer’s, it also worked. This is the latest example of research aimed at applying gene-editing technology to solving some of the toughest neurological diseases. http://www.fiercebiotech.com/research/new-gene-editing-technique-for-neurons-could-boost-research-brain-diseases
  9. Looks like CRISPR is making strides... CRISPR Therapeutics Awarded Grant from Friedreich’s Ataxia Research Alliance to Collaborate with University of Alabama at Birmingham on Gene-edited Treatments for Friedrich’s Ataxia ZUG, Switzerland and CAMBRIDGE, Mass., Oct. 13, 2017 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (NASDAQ:CRSP), a genome editing company focused on creating transformative medicine for serious diseases, today announced the receipt of the Kyle Bryant Translational Research Award from Friedreich's Ataxia Research Alliance (FARA), a non-profit organization that is focused on curing Friedreich's Ataxia (FA). The grant is awarded to fund research on in vivo CRISPR/Cas9-based gene-editing approaches to treat FA, which will be performed in collaboration with Dr. Marek Napierala at University of Alabama at Birmingham. This announcement coincides with FARA's rideATAXIA Philadelphia event, a lead location in an annual bike ride program founded by patient Kyle Bryant, that increases FA awareness and raises funds to treat and cure FA through research. http://www.nasdaq.com/press-release/crispr-therapeutics-awarded-grant-from-friedreichs-ataxia-research-alliance-to-collaborate-with-20171013-00379
  10. Not sure if this has been posted on here, but just found this published today on the Genetic Literacy Project website. Although the full article was published on September 20 at www.nature.com it requires a subscription to read the full article. I still got a bit excited... New, hyper-accurate CRISPR gene editor developed Scientists at the University of California, Berkeley and Massachusetts General Hospital have identified a key region within the Cas9 protein that governs how accurately CRISPR-Cas9 homes in on a target DNA sequence, and have tweaked it to produce a hyper-accurate gene editor with the lowest level of off-target cutting to date Genetic Literacy Project link: https://geneticliteracyproject.org/2017/10/12/new-hyper-accurate-crispr-gene-editor-developed/ Original Nature subscription article link: http://www.nature.com/nature/journal/vaap/ncurrent/full/nature24268.html?foxtrotcallback=true#access
  11. Does anybody know that if gene editing is successful, what happens the the deactivated virus? Does it degrade and disappear? Will you still be positive? Is the virus still present but handcuffed so it won't spread? Also does anybody think they can reach 100% of latency? Thanks
  12. hi, Just saw that Jennifer Doudna has won a CRISPR Patent over Editas Medicines,but seems like this is just the beginning of a war ,you think this will affect the Cullen-Bloom Progress at HSV eradication using that gene editing technology. I really hope this war doesnt delay even more the HSV cure research and tests.
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