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Full paper here: https://www.sciencedirect.com/science/article/pii/S0264410X18315652 Note sure if anyone wrote about this. I couldn't find any results for VC2 in the site's search. This is a live attenuated vaccine from Louisiana State University. The results do not seem super promising, as reducing shedding/recurrance by < 70% pre-clinical is common in many discontinued vaccines. Still, research is being done, which is always great! Prophylactic conclusions: "Our studies also showed that VC2 vaccine decreases the clinical severity of acute and recurrent HSV-2 disease in guinea pigs when provided by intramuscular vaccination. During the primary infection, animals vaccinated with VC2 had a significant decrease in clinical severity and replicating virus in the vaginal vault. Prophylactic vaccination also decreased the quantity of virus in the DRGs when compared to the No Treatment group. The ability to protect neural tissue from latent infection probably contributed to the decrease in the number of animals with recurrent lesions by 67% and the number of days with recurrent vaginal shedding by 46%. This reduction in shedding is particularly important because transmission of HSV-2 to uninfected persons is largely due to asymptomatic shedding [38], [39]." Theraputic conclusions: "When tested as a therapeutic vaccine, i.e., one designed to decrease recurrent disease and recurrent virus shedding in those already infected with HSV, the VC2 vaccine was not effective although it did reduce recurrent shedding, at least when compared to the gD2 vaccine. This may be because live attenuated vaccines have only limited replication in hosts that are already infected and thus do not have much of an impact in improving the immune response. Because infected hosts have frequent reactivations of virus that would be similar to a live vaccine inoculation it may be difficult for the vaccine to improve the immune response unless it is able to induce responses not activated by the host’s recurrent virus replication."

Hi, As expressed in the title, I am Dr. Todd Rider and I invented promising broad spectrum antiviral candidates that I have called DRACOs. I look forward to meeting you all here and hope my presence is helpful. I am here to answer any questions you may have for me --- Ask Me Anything you like. Please post your questions here and I will be online to respond during the following days and times. Oct 29th, 6-8 pm ETNov 1st, 1-3 pm ETI will also join the live chat during these times. Thank you, Todd Proof I am Who I Say I Am: http://imgur.com/PhF99cj Journal of PLOS ONE Scientific Results: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022572 IndieGoGo Campaign: https://www.indiegogo.com/projects/dracos-may-be-effective-against-all-viruses/x/6148198#/ Press Release: http://www.prweb.com/releases/2015/10/prweb13018147.htm Some Media Coverage: My Bio: Dr. Todd H. Rider studied both biomedicine and engineering at MIT, including coursework at Harvard Medical School, and has spent his career inventing novel biotechnology projects by combining molecular and cellular biology tools with a systems engineering approach. After receiving his Ph.D. from MIT, he worked at Aeiveos Corporation on in vitro experiments to test and potentially intervene in the molecular mechanisms of human aging. In 1997 he joined MIT Lincoln Laboratory and the MIT Center for Cancer Research and invented the CANARY biosensor, which uses genetically engineered lymphocytes to identify pathogens within seconds with very high accuracy and sensitivity. He engineered and demonstrated the first CANARY cell lines, as reported in his widely publicized 2003 Science paper. Dr. Rider invented the DRACO antiviral approach, designed the therapeutics and experiments, personally conducted many of the in vitro and in vivo experiments, and recruited and supervised a team in carrying out the rest. His DRACO research has been called “visionary” by the White House (National Bioeconomy Blueprint, April 2012, p. 9), named one of the best inventions of the year by Time magazine (November 28, 2011, pp. 58, 78), and featured on the BBC Horizons TV program (2013). He has also invented additional PANACEA anti-pathogen therapeutics, novel high-energy biofuel cells, and other projects. Along the way, Dr. Rider founded and runs the Science on Saturday program and other K-12 science outreach programs at MIT.

I've known my fiance for couple of years, and in our country, before we get married, it is compulsary for the couple to screen for HIV test. The test showed negative for both of us. Then we decided to take an STD test (without any symptoms) just to make sure and this test include Syphyllis, Chlamydia n both type of HSV. The results came with me having negative for all STDs and my fiance having all negative except for HSV-1 (igG blood test). I am under so much pressure right now to consider of calling off the wedding or continue with it. My concern is that how it going to affect my pregnancy and my life as a whole. I love my fiance so much, I try to support him as much as I can. I just have certain worry about my future in terms of pregnancy and whether Im gonna contract HSV-1 oral or genital? Cause my fiance did not show any symptom either on his mounth or genital Anyone can give me advice regarding this..Im so much appreciate it.

Hi..Ive been browsing around the web, and find out that HSV1 might caused eye infection and ultimately blindness..how common is this? Anyone experiencing this before?

I just being diagnosed with hsv-1 (oral) and experience my first outbreak. What worry me is that i am on my early stage of pregnancy, is there any risk i transmit the virus to my baby in the uterus? Since I never had any outbreak before and this is the 1st time I've been tested positive with hsv-1. Anyone could help me deal with this, Im so worry, I really want to make sure my baby is delivered safe and healthy

Hello, I've never had a herpes sore or any symptom in my entire life. Last week I receive a small spit of saliva in my lip when I am talking to a friend who has active sores. After that I "run" to the bathroom and washed my lips with lots of water. So far I have had no symptoms, whem exceed the incubation period of 20 days and I have NO symptoms , I can rest? Please give some advice! What I have to do to get peace in my head? or tell me if this episode is a risk of transmission? Thanks for your support

Hello there, I was recently with a guy about 3 weeks ago and since then I've had bumps under my tongue that hurt really bad. It was hard to eat and drink, the bumps lasted about 3-4 days and were gone. Some other symptoms that I feel are the tip of my tongue is numb and weird feeling and some small white bumps appearing but don't hurt. My main question, if anybody can help me with, is the guy ONLY sucked my nipples. Can I contract HSV-1 through him sucking on my nipples? Thanks for any information given.

Saw “Downsizing” this weekend. It’s the new Matt Damon movie. Toward the end (no spoilers— don’t worry), an important scientist in the movie introduces a young man who was the first baby born in the downsized world. The young man smiles and he has a huge, red, glistening cold sore on his lip. From the audience in the theatre, it was mostly silence. But I heard a few snickers, a few laughs, and a few groans. My boyfriend, who I had just told of my new HSV-1 diagnosis (and he is my giver but he denies it), leaned to my ear and said, “He’s got the Herpes,” loud enough for the people around us to hear. At least he didn’t say, “He’s got YOUR Herpes.” https://youtu.be/QKEPCcPVrx0

Has anyone read this or tried it?

I’m not promoting this product in any form to benefit myself. I was talking to a friend who is in medical school currently here and there is some research and experimentation going on regarding treatments for OHSV-1 in the virology lab as well as the dental school. One of the dental professors tried to use a green tea extract on one of his patients and it worked so well that he came up with this ointment, which they seem to frequently use to treat patients here who have cold sores and it has shown to be very effective. If anyone wants to try AverTeaX here is the link for it: https://www.amazon.com/dp/B00AXA5FYI/ref=cm_sw_r_cp_api_sW48zbHWNWWVW

How can you best protect your wife and other family members from your infection?

Hi all, Im 19 and currently a sophomore in college. I was diagnosed with genital HSV-1 about a week ago after going to the doctor for what I thought was a really bad yeast infection. Turns out it was the beginning of my first OB! Im almost positive I contracted HSV from a cold sore on the mouth of a guy Ive been seeing for a few months after he gave me oral. Its been 8 days since it started and today is the first day that I have been able to walk around and go to the bathroom without excruciating pain. Needless to say, I will never take the ability to sit, walk, and pretty much just exist in comfort for granted again. Now that I am able to focus on something other than the pain of the first OB, I am beginning to research the ways my diet and lifestyle need to change in order to prevent more OBs in the future. There is so much information I just dont really even know where the best place to start is. In addition, I am a college student and as a result experience a high amount of stress pretty frequently and I am definitely no stranger to alcohol, late nights, and not enough sleep. I am very aware that these are all things that do not mix well with HSV. Hoping someone with have some insight into how to balance HSV with the lifestyle of a broke, stressed out college student that wants to avoid the pain of another OB AT ALL COSTS. -Ally

Hey everyone. I'm new to the site, but I've unfortunately been getting cold sores (orally) since I was very young. (Presumably contracted from a family member as a child/baby) This past year I have had 6 outbreaks. (Usually I have 1 or 2 max a year.) I've been under a lot of stress, more than usual, but now it's just getting too much. I have been suffering from clinical depression for over a decade and an anxiety disorder for about 6 years, and even through all of that, my OB's never became more frequent, until this year. I take Lysine daily, Vitamin C, try any foods to boost the immune system, especially those high in Lysine and low (or no) arginine, as well as a Virulite system, which actually did seem to shorten my last OB. (Usually they last about a week or sometimes even 2 or longer, using the virulite, my cold sore had come and gone in exactly 4 days. Suffice to say, I was absolutely elated.) I was just wondering if anyone can relate to a highly stressful life (I'm a full time carer to a very stubborn, disabled family member, hence the high stress) and has had any luck with preventing outbreaks? If so, how? I'm in a long term relationship with a very carefree fella, who has HSV-1 also but doesn't ever seem to get outbreaks. (The boy just never stresses haha. But I don't want to be giving him unnecessary cold sores or worse, spreading it to him through oral sex.) Just looking for some tips on either dietary, natural or medical tips and tricks that have worked to keep the virus dormant for others for more than a few months. Any help/advice is appreciated. Thanks all. Warmest greetings, LillysMum

So is it just me or does anyone else notice we have an increasing number of people signing up each day on HC alone? Does this maybe suggest the rate of infections is increasing? Sucks to see more people being victims of this virus.

http://jvi.asm.org/content/91/22/e01295-17.abstract

I’ve been recently diagnosed with Hsv-1 by a blood test so idk if the infection is in my mouth or gentials cause I haven’t had any symptoms. But I’m going back and forth between feeling okay & then feeling contagious . I have so many questions & I don’t want to travel all the way to the doctors to get them answered . I know the basics but I just want my particular questions answered. Does anyone know where I can get my questions answered by a doctor online ? Or someone who is really educated on the subject that I can email .i honestly feel like I would feel better if I get my questions answered.

Has anyone who submitted their General Medical History form for Rational Vaccines' Theravax HSV-1 Safety Trial heard anything from Minerva Labs or RVx on the status of the trial or whether they were accepted? Anything you you can share? Any direct information would be much appreciated. Thanks.

Hello! So this is another post from me because, once again, I'm not sure if I'm having an outbreak! I've only ever had two definite OBs; My primary OB which was terrible, swelling, about 10 sores up to 5mm in diameter on foreskin and frenelum, painful and swollen lymph nodes in my groin, lasting about 2-3 weeks until I was back to normal. Then unsure of if I was having them for about 3-4 weeks but I think it was just scare tissue from the healing sores. About 5 weeks after initial OB my definite Secondary OB which was only 1 sore around 3mm on my foreskin, slight/no tingling, no pain, no swelling in my nodes, this lasted about a week until fully healed. Now, I remember how the stinging, tingling, feeling felt of my Primary OB and I've never experienced that since, I am at around 10 months since my Primary OB and other than the above occurrences I've never been able to tell if I'm having an OB. All I've had is the occasional red dot that's around 0.5mm either right under my glans at the join to my foreskin or on the corona of my glans and it doesn't seem to ever act like a sore, doesn't blister, no pain, doesn't seem to be a little hole in my skin but more of a bump outwards and it hasn't been in the same place as my Primary or Secondary OBs. I can't seem to tell if I'm just experiencing redness, thrush, irriation or a popped blood vessel after sex with my girlfriend or masturbation. I'm starting to drive myself mad with checking in case I am indeed having an outbreak and I can't seem to find any information on this! Basically what I'm looking for is descriptions of what you all experience with your OBs, HSV1 or 2? size of your sores, number of sores, location (glans? Corona? Frenelum? Foreskin?). I know that may seem weird but I need to see if what I'm experiencing is an OB. I think this may help a lot of people know what they're experiencing! Thanks for any answers! H

Hi, all! A bit of a long read here, but definitely appreciate advice from anyone who has the time to give it!I disclosed my genital HSV-1 to the wonderful man I'm dating about a month ago, and he took the news better than I could have hoped for. We have not had sex yet, and because I really care about him, I wanted to make sure I shared my status with him before we did. (Note: this is the first time I've disclosed to a partner since my last relationship and my first partner since that relationship in general.) Not only did my status not turn him off from me (I disclosed via letter sent by email and he was grateful for my honesty/wanted to talk face-to-face the next day), but the conversation has brought us closer in terms of openness and intimacy. Both of us have scheduled doctors appointments. He'll be going for a general checkup and STD testing, and I'll be refilling my antiviral prescription. He has done a significant amount of research since our initial conversation and has asked many questions. He genuinely wants to explore ways in which we can be physically intimate while protecting himself and making sure I still feel sexy, which I appreciate very much. He says I'm very special to him.As it nears time for us to give sex a try for the first time, however, I'm finding myself feeling anxious. Since this is the first time I'll be having sex with someone since my last relationship, which ended a little over two years ago, it's really just now hitting me how different sex will be in terms of freedom. I fear the limitations (he has expressed his preference not to perform oral sex on me, despite it being one of his favorite things, which I understand and respect) may have a strain on our relationship down the line, and I want to be able to satisfy him to the best of my ability, despite not being able to have sex as "freely" as I was once able to.Though he says my status doesn't scare him and he cares about me very much, part of me feels like he may also be more afraid than he's revealing to me, which I also understand. He did admit that when I initially gave him the news, he felt as if it was "unfair" (i.e. he finally met a woman who's perfect for him, but he doesn't have as much access to her sexually because of her status). He says he realized how selfish this was before he ultimately decided he still wanted to move forward in our relationship. He's brought up things like wearing boxer briefs during sex and spraying down with rubbing alcohol during times "we're not so sure" because apparently rubbing alcohol "kills" the virus on the surface of the skin (I've never read anything backing this up, so not sure how accurate it is, and also feel he's overreacting a bit/doing a bit much in this regard). While I understand his right and desire to be as careful as possible, it admittedly has stirred up some insecurity, and I've been struggling with self-esteem a bit. I know finding our groove won't be easy, but I also strongly feel it will be worth it in the end if I can work through everything I'm feeling. I trust he means what he says when he says he cares and finds me insanely attractive.Is anyone else struggling with is or has anyone struggled with this previously? Would it be worth it to express these feelings to him? I became overwhelmed and ended up crying on his chest the other day during a conversation about how we were going to protect each other. Not only do I *not* want to pass this along to him (and I know the risk is inevitable), but I also really want this to work. He's both a partner and one of my closest friends.Thanks for reading!

Interesting study. Mothers with a previous history of HSV-1 infection may pass protection onto their unborn child. While this study points to protection, it is not quite a conclusive study. Mice as well as human tissues were used to lend to the author's conclusion. Still, the human body is pretty cool. Also very exciting is the notion that while vaccines to date have not been effective for HSV sufferers, there have not been studies to see if a vaccine could provide protection to a mother's unborn child. For example, some failed vaccine stimulate an immune response but that immune response does not last (so the vaccine does not get to market). However, it would be interesting to see if vaccines administered during pregnancy might help provide protection to the unborn child, even if it doesn't treat the mother. https://www.sciencedaily.com/releases/2017/07/170705104102.htm Paper's abstract: http://mbio.asm.org/content/8/4/e00678-17

wasn't sure where to post this. Only seems right that we pay tribute to this angle as its a matter close to our hearts and it has featured in every news paper around the world today. no doubt in her 18 days she will make a impact to the word. im glad we all do our best to stay safe and keep others safe. http://www.womansday.com/health-fitness/a59592/deadly-virus-newborn-kiss/ RIP Mariana

Hi, You know, I really don't know how to word this in a polite way and this may be too blunt/TMI for some...So, **Warning. I have facial herpes, yay. It's been a year. I miss giving blowjobs to my husband and haven't because I feel like it's taking a chance of spreading it to both of our nether regions. Now, I'm pregnant. Intercourse is sadly not comfortable for me right now...and I want to make my man happy and me too. Is a BJ with facial herpes too risky? I hate you Herpes.

So, I am a dental assistant and have dreamed of being a RDH and a year ago I was diagnosed with HSV-1 and I am distraught I have since left the health care field because I fear getting pricked by instruments. Of being an occupational hazard and having to disclose my diagnosis to my employer. I am just wondering are there any people in the dental field or medical field that have a diagnosis of hsv1 and it hasn't affected their everyday work like?

Edit: so I jumped the gun too quick due to an e-mail alert; this paper is dated 29 February 2016. For some reason I thought that was today I'll leave this here for anyone who wants to read it but it is not new content. Researcher from Temple University, whose research will likely feed into Excision Biotheraputics, have published a paper on gene editing and HSV-1. I haven't been able to read the whole thing and won't until later tonight. If someone else has time feel free to provide your interpretation of the content. On brief review, in cell cultures (think petri dish - so not in animals or humans) it seems they showed proof-of-concept in "profoundly" reducing the virus and also, quite cool, protected other cells from viral infection. If this is true, it may be possible to use CRISPR/Cas9 technology to not only rid the body of the virus, but actually protect uninfected cells and potentially non-infected individuals from the virus [prophylactic application] (but don't quote me on this yet as I haven't read the whole thing). A promising read later. http://www.nature.com/articles/srep23146

https://www.herpes-coldsores.com/cold_sores.htm Home topic to share knowledge, talk about recurrences and any questions