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  1. What’s up all!! I just wanna let you guys in on my first year of having hsv-2. I’ve had a very little first outbreak 2 small “sores” that were kinda apart, was scared went to urgent care and requested blood work and full STD PANEL, everything came back negative except for HSV-1 which I had as a young boy, and HSV-2 via IGG blood test. I must have had it for a while since it takes a while to build antibodies ( my levels were like 8 or9). Another reason I was scared was my gf was having UTI symptoms which she tested positive for it but I had her go get tested for HSV and she was positive via IGM...she was given antivirals but she only took them for a week. Now fast forward to here, we do not have any outbreaks or they might be so small we don’t even notice. We have a great sex life and are going strong. We do not blame each other because we both didn’t know who carried it first. But anyways just wanted to give update on my year and how it doesn’t bother my at having this disease, I forget about it most of the time. Thank for reading and god bless you all!
  2. Full paper here: https://www.sciencedirect.com/science/article/pii/S0264410X18315652 Note sure if anyone wrote about this. I couldn't find any results for VC2 in the site's search. This is a live attenuated vaccine from Louisiana State University. The results do not seem super promising, as reducing shedding/recurrance by < 70% pre-clinical is common in many discontinued vaccines. Still, research is being done, which is always great! Prophylactic conclusions: "Our studies also showed that VC2 vaccine decreases the clinical severity of acute and recurrent HSV-2 disease in guinea pigs when provided by intramuscular vaccination. During the primary infection, animals vaccinated with VC2 had a significant decrease in clinical severity and replicating virus in the vaginal vault. Prophylactic vaccination also decreased the quantity of virus in the DRGs when compared to the No Treatment group. The ability to protect neural tissue from latent infection probably contributed to the decrease in the number of animals with recurrent lesions by 67% and the number of days with recurrent vaginal shedding by 46%. This reduction in shedding is particularly important because transmission of HSV-2 to uninfected persons is largely due to asymptomatic shedding [38], [39]." Theraputic conclusions: "When tested as a therapeutic vaccine, i.e., one designed to decrease recurrent disease and recurrent virus shedding in those already infected with HSV, the VC2 vaccine was not effective although it did reduce recurrent shedding, at least when compared to the gD2 vaccine. This may be because live attenuated vaccines have only limited replication in hosts that are already infected and thus do not have much of an impact in improving the immune response. Because infected hosts have frequent reactivations of virus that would be similar to a live vaccine inoculation it may be difficult for the vaccine to improve the immune response unless it is able to induce responses not activated by the host’s recurrent virus replication."
  3. 48 hours ago I noticed an odd pattern of red, slightly raised marks on my inner thigh next to my testicles. (The smaller red bumps above it are from shaving and usually happen appear for a couple days then diminish) Went to walk-in clinic this morning and the doctor was confident this is not herpes but more likely a skin infection like folliculitis or acne (I have issues with acne). I asked for a swab and the doctor told me that it was not necessary and prescribed an antibacterial & steroid cream to apply twice daily. I also asked for a HSV blood test and the doctor said the test wouldn't tell me which type of HSV it was if I had it. She said if I had cold sores before, it would come back positive and be misleading for this infection (I informed her I never had a cold sore before). They haven't changed in progression over the 48 hours. Just seem to get a little less red at times. I will see my family doctor when she is back from vacation but hoping for second opinion here. Thoughts? CLOSEUP 1 CLOSEUP 2 THIGH 1 THIGH 2
  4. anom1990

    Well… here I am.

    Hi everyone. I’m still trying to process this but I am a gay male in my late 20’s that was recently diagnosed with HSV-2 in October 2018. I haven’t been sexually active since 2015 and have only engaged in sexual activity with four people in my life. I’m feeling a lot of emotions because of this; sad, angry, confused, violated, ect. Thoughts like who would’ve thought someone like little ole me, compared to all of the VERY promiscuous people in the world, would end up with Genital Herpes ESPECIALLY when I’ve been abstinent and just focusing on myself for years. That was a gunshot to my soul. It’s crazy that I’ve ALWAYS done regular STD testing, thinking I was negative for everything only to find out that Herpes was never included in my testing because I never knew you had to literally ask for that until this year. The CDC and medical industry is so fucked up and wrong for that. I’ve always used protection, except with my first boyfriend but that was back in 2009-2010 and a condom broke with a sexual encounter I had back in 2011 and I remember immediately putting a new one on him. Unfortunately, all of the men I’ve dealt with sexually are questionable. Half of me wants to know who gave this to me but the other half is like what’s the point. I only have access to contact three of them (I don’t know where the other guy is) but I haven’t spoken to two of them in years, one of them in a whole decade and it would be pretty awkward for me years later to write them a message about herpes. My first boyfriend and I are cordial but he’s still immature so it would be very awkward with him. Anyways, as I’ve been thinking and backtracking my life, I would think I caught this back in 2011 because I remember my anus itching so badly but I thought it was just my hair growing back because I do recall shaving before having sex so I guess that was my first outbreak. Other times I would just get a minor itch in and on my buttocks but I never would’ve thought herpes. I’ve never got outbreaks on my penile area. This is all still confusing and baffling to me. I’m still sad and feeling like my future love life was taken from me. I feel like part of my confidence was taken from me. I don’t even feel comfortable flirting and finding people attractive right now. I’m just releasing my thoughts about my situation but I do have questions. My results also came back saying I had extremely low Vitamin D deficiency; does HSV-2 have something to do with that? Is there a test I could take to tell me exactly when I contracted this virus? This question may be TMI but I masturbate and I notice that a lot of sperm doesn’t cum out sometimes, does HSV-2 have something to do with that?
  5. FIRST TIME TO WEBSITE. HELP.... Had a single small spot show up on my penis. Never had anything like it occur previously. Showed up the morning after having oral and vaginal sex with my wife, each of the two previous days, like 6 hours after intercourse. Went to my doctor the next day and he was unsure but suggested testing for HSV-1 and HSV-2 as precaution. Lab Test Results: IGG HSV-1 = <0.90 Negative IGG HSV-2 = 9.55 (>1.09) Needless to say I'm trying to wrap my brain around all of this.... Is it possible the above is a false positive? Have been tested in past and been negative. I don't know how I contracted it. All very upsetting but my real concern is my wife. I'm married in a monogamous relationship and have not been with anyone else for over 3 years. My wife and I are very sexually active, having sex multiple times a week most weeks since August 2015. I think the longest we have gone without sex is like 2 weeks and that's been very rare. My wife has oral cold sore out breaks multiple times a year but to my knowledge hasn't had any genital herpe symptoms and has never been tested for HSV 1 or 2. What is the likelihood my wife has HSV-2? That she contacted HSV-2 from me, that I contracted it from her or that we both came into the relationship with it? The reality is none of this really matters, I'm just so upset that it involves her. My worst nightmare. Since the spot popped up I have refrained from being sexual with my wife. Felt like it would be a breach of trust to be sexual with her without telling her there could be an issue. I wanted the test results first and wanted to discuss with her so, if there was an issue, we could work through this together. Its been two weeks and she has started making comments about not having sex and asking if something is wrong SO I have to address this now. Shouldn't she go to the dr? Shouldn't we go together? Shouldn't she get tested? My doctor, whom she goes to for general stuff as well, has acted like no big deal. Told me I could have had this for years or gotten it six months ago, no one knows for sure and people have this and deal with this all the time. Obviously, if she is negative iy can't be a resent infection. He has suggested suppression therapy of 500mg Valacycovir daily for each of us. Any thoughts or comments? Thank you.
  6. Since May I have been taking Valtrex. At first it was 500mg once a day then it increased to 1000mg once a day in June after frequent outbreaks persisted. I've had a total of 9 outbreaks since May and was diagnosed with hsv2 in March of this year. The past three weeks I've had severe dizziness, especially when lying down and getting up in the mornings. Today my doctor suggested taking acyclovir 400mg twice a day. Has anyone switched from acyclovir to valtrex and experienced better results/less breakouts?
  7. Hey all, Some people have posted about Tenofovir before - I found an article today that confirms a reduction in transmission with use of the gel. Medical Article: http://www.nejm.org/doi/full/10.1056/NEJMc1511338?af=R&rss=currentIssue Other articles giving a succinct report: http://www.capahc.com/en/tenofovir-gel-for-the-prevention-of-herpes-simplex-virus-type-2-infection/ http://www.medicaldaily.com/tenofovir-gel-may-lower-risk-herpes-simplex-virus-type-2-women-voice-results-308099 Due to the nature of the product, I thought it better to put this post under the "Prevention" thread. Cheers!
  8. Today Admedus released their Phase II interim results with the main points being, 58% decrease in viral shedding No safety issues relating to the vaccine Immune responses were generated only in the vaccine group Unblinded analysis on first 20 patients (15 vaccine, 5 placebo) recommendation following independent review to progress vaccine full results to be released 1H 2017 To read the full announcement the link is here http://www.asx.com.au/asxpdf/20161019/pdf/43c35546jbmprc.pdf What are other peoples opinions on this trial? they seem to be the best results around, I think Admedus will come through with the goods. Especially considering Professor Ian Frazer is conducted the research his last vaccine Gardasil used to prevent HPV did wonders for people all around the world, Geno's results wern't as good and Bill Halford's trial seem's suss i dont think that will go very far.
  9. Hey all, I'm kinda new to this and have a question about being in a long-term relationship with someone who is HSV-2 negative. So there is someone I'm hoping to date (haven't disclosed yet) and I'm hoping he will like me enough to still want to go ahead once he hears I have HSV-2. So, crucial to the story is that I have a genetic disorder that means I cannot take the birth control pill, and hence have to use condoms. So, my question is, if I'm taking anti-virals and he is HSV negative, obviously we have to use condoms for actual intercourse (so as to avoid pregnancy) but does it mean that there can be no genital skin to skin contact whatsoever at all? What is the chance of me passing it on to him if I'm on the meds but we fool around without a condom? I just have a feeling that always having to wear a condom to even touch somebody is going to be a deal breaker for him and most guys. Any advice on this from people in relationships with non-H partners would be so very appreciated! Many thanks!
  10. Hey there! I'm hoping you guys can help me sort this out, as I'm really frustrated at the moment. Apologies in advance for the novel! So the situation is this... Trying to be a responsible adult, I had my doctor order a full STD panel a few years ago. In Dec 2015 I tested positive on an IgG test for HSV-2. My value was >8.0. Had them retest me again a year later (again an IgG) and my value came back as "positive" again (with no number value - the test just either said positive or negative.) When I had these tests done I wasn't showing any symptoms and I didn't have any scrapings or cultures run. So it was just the IgG tests. The positive result came as a huge shock to me. And my doctor at the time never talked to me about the results. So I just assumed from that day onward that I had HSV-2 - and he prescribed me Valacylovir basically because I asked him to. (Because I'd read that's what one should take.) So what do you all think? Do I have HSV-2? I've been living with the impression since the IgG test - and the mental anguish - that I DO indeed have HSV-2. Her comments have made me feel like wanting to know my own medical status is asking too much and that I'm making too big a deal over potentially having herpes. Ok, so I just got a response from her (I wrote her a somewhat disgruntled letter last night.) She makes the distinction between "active" disease and "exposure." And that "you are not considered to have active disease until you have diagnosed lesions." Sounds like it's usually the other way around and the IgG test is done to confirm the swabs/culture. Anyway, she says she's following the CDC guidelines. But I think she's misunderstanding what the CDC guidelines are: CDC says: "Asymptomatic persons who receive a diagnosis of HSV-2 infection by type-specific serologic testing should receive the same counseling messages as persons with symptomatic infection. In addition, such persons should be educated about the clinical manifestations of genital herpes. Because nearly all HSV-2 infections are sexually acquired, the presence of type-specific HSV-2 antibody IMPLIES ANGONITAL INFECTION. Intermittent asymptomatic shedding occurs in persons with genital HSV-2 infection, even in those with longstanding or clinically silent infection. " I read that to say that, yes, I have it, despite being "clinically silent" (i.e. no lesions) and that I'm still contagious. I don't think she should be telling people that they don't have "active disease" when they're still ultimately contagious. Do you all agree with my conclusion? (And btw, I live in CA and apparently we have a law now that says you must disclose if you know you're positive. So it's even more important that I know for sure.) Thanks so much for your advice and feedback!!
  11. http://collections.plos.org/sti
  12. Check_Twice

    Low Positive HSV-2

    About four months ago I decided to get a full panel STD test. I didn't have any symptoms or reason to get checked other than just wanting to. I went to Labcorp and got my blood drawn. A few days later I received the results, and to my horror I came back positive for HSV type 2 with an IGG score of 1.99. I was in complete shock when I saw the results. I started googling herpes since I knew next to nothing about it, and discovered that there was a chance that it could be a false positive. Anything under a 3.5 falls into a low positive zone where the test could be a false positive. The only way to know for sure was so send my blood off for a Western Blot test, which is 99% accurate. So I waited the three months that they recommend and then sent off for the test. The process was really easy. I just contacted Terri Warren at westover heights clinic and she helped me with everything! It was by far the longest three months of my life though. I got the results back today and I am NEGATIVE!!!!!!! If you are diagnosed but fall into that low positive zone, do yourself a favor and get the western blot. It isn't cheap but it is worth the peace of mind. This is a forever diagnosis.
  13. Antoinette63

    Drunk Night without Disclosure

    I’ve been talking to this guy for about a month. We are not exclusive, by we hangout regularly. Two weeks ago, we went out and got really drunk. Like, I was in and out of sleep drunk by the time we got to his house. He ate me out 2 times, we fell asleep then he took me home. When I wokeup the next morning, I felt really bad. I try to disclose before sex, but I was too drunk that night. I still haven’t told him. We haven’t done anything since then. I don’t know how to backtrack and disclose. I normally tell before clothes come off. He keeps saying that there’s something I’m hiding but he knows it isn’t bad. I’m just afraid to tell him because he knows so many people at my job and in my community. Just need some ideas/help on how to tell him now that we’ve been intimate.
  14. https://www.medicalnewstoday.com/articles/306175.php?sr “After looking for signs of viral exposures in blood samples, the researchers found that exposure to CMV, HSV-2 or toxoplasma is linked with aspects of cognitive decline typically considered to be age-related decline.” Fucking hell..
  15. http://www.nanobio.com/vaccine-pipeline/hsv-2-vaccine/
  16. http://www.profectusbiosciences.com/pipeline/pbsvax.html#hsv-2 HSV-2 Profectus is developing a GeneVax® prime/VesiculoVax™ boost therapeutic vaccine for herpes simplex virus type-2. This vaccine is designed to ameliorate disease and transmission by preventing HSV-2 reactivation and shedding.Program Status: Antigen discovery stage. Unmet Medical Need: Herpes simplex virus type 2 is a sexually transmitted virus that causes watery lesions in the skin and mucus membranes of the genitals. It establishes latency in neurons, from where it can sporadically reactivate to cause shedding/transmission with or without new sores. The CDC estimates that 776,000 people in the United States are newly infected each year. Currently, control is only possible with life-long drug treatment.
  17. Have any HSV+ folks here gone ahead and fathered a child after diagnosis, either naturally or by AI/IVF?
  18. So my basic understanding is: 1. Virus enters via the skin or mucous membrane. 2. Seeks the nearest nerve and then generally, in the case of hsv2, migrates to the sacral ganglion at the base of the spine where it occupies the neuron of the nerve cell. 3. Once in the nerve ganglion it will shed virion which generally make their way to the surface to shed and spread to other hosts (where an OB will or won’t happen). 4. The virus will also replicate and may spread further in the nervous system but generally remain in the same area. Is the above generally correct? If so my question is, does the virion that occupies a nerve cell ever actually leave the cell during an OB it does it just shed virion that goes to the surface? If the virus that occupies a cell actually goes to the surface would it be possible to eliminate if a therapeutic cure was found?
  19. Haven't heard much of this vaccine until recently. As far as I know, this is a prophylactic vaccine. Nice to see them get some funding. More about the vaccine http://www.nanobio.com/vaccine-pipeline/hsv-2-vaccine/ Link to news article http://www.prnewswire.com/news-releases/nanobio-receives-sbir-grant-for-genital-herpes-vaccine-300418367.html
  20. Does anyone know if systematic symptoms show up later after already having the primary infection? Diagnosed in August after losing my virginity and have had UTI’s nonstop, unable to sleep well, and feeling fatigued and overall crappy for 3 months now as you all know. No headaches, back pain, swollen lymphs, etc for this entire time, but now it seems like the various symptoms people point out about ghsv-2 are taking their turns on me. I had tender lymph nodes in my groin, under my armpit, and one in my neck last week. I got a colonoscopy/endoscopy last week as well for gastric issues I’ve never had and these 2 small blisters appeared on my lip that didn’t hurt but made my lip feel like it was swollen on both inside and out, itching on my arms and sometimes face. and my entire face has been flaking and feels really bumpy for the past several weeks (lots of bumps on forehead). Today I was feeling fine all day and now I started feeling like I have a bad UTI and started getting a headache for the first time since these months. Can anyone explain this or help? (I only took antivirals initially but not anymore because if I do have GHSV-2 then I want my body to mount a response).
  21. Is it possible for an HSV2+ man to have a baby with an HSV- woman by IVF without transmitting? Is the male sperm already damaged at the DNA level? Is the sperm contaminated or can it be during ejaculation for IVF? Has there been any scientific study on this?
  22. Quoted below; http://www.sciencemag.org/news/2009/11/herpes-never-sleeps Herpes Never Sleeps By Martin EnserinkNov. 18, 2009 , 12:00 AM A new study suggests HSV-2, seen here as orange particles, is constantly active even when patients don't have symptoms. Dennis Kunkel Microscopy Inc./Visuals Unlimited, Inc. Genital herpes comes and goes--at least that's what it looks like to patients. But a mathematical model published in the 18 November issue of Science Translational Medicine suggests that herpes never slumbers. Instead, nerve cells continuously pump out the virus in minuscule quantities over a sufferer's lifetime. If the findings hold, it may be much harder to stop patients from passing on the infection than researchers thought. As many as one in five people is permanently infected with herpes simplex virus 2 (HSV-2), the most common cause of genital skin ulcers. The virus is transmitted during sex; after infection, it retreats into nerve cells that have their endings in the genital skin. HSV-2 causes no problems in up to 80% of those infected, but a minority suffers from blisters and sores once or twice a month. For decades, most scientists believed that the virus was simply "off" in the intervals between outbreaks, says William Halford, who studies herpes at Southern Illinois University School of Medicine in Springfield. But that view has come under fire the past decade or so, as researchers showed that the virus is sometimes present in the genital skin even when no lesions are apparent. The new work, by infectious diseases researcher Lawrence Corey and his colleagues at the University of Washington and the Fred Hutchison Cancer Research Center, both in Seattle, goes even further. Joshua Schiffer, a clinician and mathematical modeler in Corey's group, constructed mathematical models from a large amount of virological and patient data--including the amount of virus present in the skin of patients who took four swabs daily for 60 days. This is what appears to be going on: Nerve cells shed tiny amounts of virus almost constantly inside the genital skin. Frequently, a virus will infect an epithelial cell, which compared with a nerve cells are "real virus factories," says Schiffer: They produce massive amounts of virus that can infect other nearby epithelial cells and can presumably also infect sexual partners. In most cases, infected epithelial cells are quickly killed by CD8+ cells, a type of white blood cells; only occasionally does the infection overwhelm the immune system, resulting in a lesion. "It's impressive that they were able to build a model that makes sense of a large amount of clinical data," says Philip Krause, a herpes researcher at the U.S. Food and Drug Administration. "It's a very thoughtful way of looking at the data." Halford says the paper should help dispel the notion, still supported by many herpes scientists, that the virus "does nothing" between clinical episodes. The findings may also explain some properties of antiherpes drugs like acyclovir, says Schiffer. For instance, in a trial where herpes patients took acyclovir to prevent their partners from becoming infected, the drug was only 50% effective. If virus shedding never stops, these drugs have a much harder job, says Schiffer, especially compounds like acyclovir that quickly disappear from a patient's body. To really prevent transmission, drugs would have to last longer or stop the shedding by the nerve cells, he adds--but that's a tall order.
  23. How can you best protect your wife and other family members from your infection?
  24. I’ve have been really nauseaus, on and off for most of this month with tingling in my feet and legs, also today extremely dizzy and tired but no apparent blisters. I have not been diagnosed yet but I don’t know what else this can be. I’m awaiting blood work but the doctor says it is likely my stress and imagination. I don’t see how it can be, I know my own body and realize this is not normal. I’m at the end of my rope and worried about possible nuerological issues from this. Is it normal to feel very dizzy and tired like this or have I possibly got the onset of menningitis? my original post here: https://honeycomb.click/topic/73213-not-diagnosed-but-some-symptoms/
  25. I’m really, really scared, freaking out, depressed right now, and need some help. A lot of you might already know my story, but herpes has me freaked the fuck out now. I’m 25 years old, have always been a highly active person all of my life, have always eaten right and healthy, and haven’t ever dealt with any major health issues. I’m assuming I do have GHSV-2, but don’t know for sure yet, but was diagnosed visually and with a igg of 2.0. Since 4 months now after coming back from being abroad I don’t have any appetite, feel like I have food in my stomach, pronounced heart rate, shortness of breath, and just overall feeling of being unwell. I was told by a forum member that my vagus nerve could have been affected by the virus or maybe some other virus and caused me to have gastroparesis, causing me to feel full really quickly because my stomach isnt able to empty itself, and it isn’t curable apparently when I googled it!!? How am I supposed to live my life with having this virus and also dealing with not being able to eat and supposed to not die from losing weight?! On top of this I read diabetes is frequently a cause for this? No one in my family that I know of has diabetes. What the fuck has my life turned into?!?! All because of wanting to have sex one time in my life?! I have never dealt with anything like this in my life.
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