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Found 26 results

  1. Eradicatethefuckouttahsv

    Antibiotics against herpes?

    https://cosmosmagazine.com/biology/antibiotics-do-work-on-viruses
  2. Hello world! I had my first HSV2 outbreak 8 years ago. The first one is the worst -- the actual outbreak hurts like hell. The outbreak itself was very tiny and localized in a small genital area. However It came with side effects I didn't expect like an acute and intense tingling sensation in my lower back, buttocks, and spread down to my feet/toes. Fast forward years. I rarely get actual outbreaks if ever. But I do experience that intense nerve pain I remember that comes before an outbreak manifests as a skin lesion. So now the outbreaks don't happen, but the prodrome pre-tingles happen often. Except now those piercing sharp tingles aren't just perceptible in the aforementioned areas. I feel it all over my body intermittently - neck, shoulders, arm, yes leg and lower back, foot, etc.. To emphasize, I never experienced any chronic pain remotely similar to "herpes tingles" pre- first HSV 2 outbreak. Several Questions: Does this pain sound familiar to you? Has it migrated outside of where it was when you first had an outbreak? When I bring this up to multiple doctors, I'm baffled that they have no idea what I'm talking about. Or don't see the connection between the nerve(?) /lymph node (?) pain / neuralgia/ paresthesia and HSV. Every time I see a "Lyrica" commercial for fibromyalgia I think to myself, "well this is fucking it. this is what I'm feeling/experiencing in my body." Is there a link between fibromyalgia and herpes? I wonder how many patients diagnosed with fibromyalgia have either HSV 1/ HSV 2/ shingles/ varicella-zoster viruses or something related? It seems to me there is a there there. But I also feel I'm being gas lit by the world and that in general researchers / HCPs are too "embarrassed" to even commit to research around the "not talked about" symptoms of HSV; or even HSV in general. How can herpes be so "common" and yet not a single medical professional is conversant in the totality of the disease or specializing in it? >_< Not related, but where can I purchase acyclovir cream? That stuff is like contraband in the USA lol. ugh this country sucks in this arena.
  3. "For the first time, researchers have been able to use cryo-electron microscopy, to reveal the detailed structure of the common herpes virus." Sup y'all... this is the real-deal. The main problem with this disease has been that researchers literally haven't been able to see it... until now. So no wonder everything has failed miserably except our friend Valacyclovir Hydrochloride. It's amazing seeing this... isn't it kinda beautiful actually? This particular research was on HSV-1, but the work is ongoing and will be done on HSV-2 and all other herpes variants. If we can see it, we can kill it. I'll be paying attention to this research group like crazy now! Here's one article: https://www.gla.ac.uk/news/headline_596519_en.html And here's the actual study- with pictures! https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006191 Here's the guy doing the study (my new hero lol): https://www.gla.ac.uk/researchinstitutes/iii/staff/davidbhella/#/researchinterests,grants,publications,articles And here's the research's group on their HSV-1 work: https://www.gla.ac.uk/researchinstitutes/iii/cvr/aboutus/viruseswestudy/hsv1/ So yeah just my opinion but finally no more shooting in the dark- drug companies will be all over this and start creating new treatments based on the actual structure of this damn organism, so I'm very hopeful indeed.
  4. AllHailKarma

    Everything is gonna be fine.

    Anyone else actually legit ok? After doing the research, finding out how to keep myself healthy, how to keep this in dormacy, plus seeing how large of a community is on this side of the fence.... like, I'm good. And everyone else really should take the time to read, watch videos, figure out how your own body works with this shit, keep this community close also. We're all gonna be fine. I'm more annoyed by occasional indigestion honestly.
  5. If you’ve followed this ASP2151 thread, you may know that I’ve been taking amenamevir (Amenalief) for about two months. In these two months, I have had absolutely no symptoms and no side effects to speak of. I’m ordering blood work soon to confirm that there are no major changes in important biomarkers (kidney, liver, heart, etc.) but I haven’t experienced any side effects that I could observe myself (headaches, diarrhea, insomnia, mood changes etc.) However, there is no data about the effectiveness of valacyclovir + amenamevir on reducing HSV recurrences. Two months of being on this combination is not enough to tell how well it works. As a community, what we need is a functional cure. There’s a lot of excitement surrounding pritelivir in this regard. Pritelivir, like amenamevir, is a new drug inhibits the HSV helicase-primase complex. This is a different target than valacyclovir, which is why combining the two has major potential to be a functional cure. If you’ve read Josh Bloom’s article on the possibility of using pritelivir and valacyclovir together as a sort of HIV-like cocktail, then you’ve probably realized this combo is the only way in the foreseeable future that we will have a functional cure. Here’s the reality of the situation. There will not be a vaccine in the foreseeable future (barring a miracle that allows GEN-003 to continue. I wouldn’t count on that). There will not be a CRISPR treatment in the foreseeable future. The only HSV drug that is going through clinical trials (past pre-clinical) is pritelivir. That means that aside from amenamevir and pritelivir, there will not be any new drugs on the market for at least ten years. You are not getting much help from the pharmaceutical companies. It’s the truth. Many people here are already aware of this. Look at the HSV pipeline. Other than the helicase-primase inhibitors, there is little to no progress being made, and the failure rate is incredibly high. If you want, you can wait ten years hoping that the pharmaceutical companies come out with something. The only alternative is to conduct our own trials and gather some data. There are plenty of drugs/supplements with studies that have some evidence to support their use in preventing HSV recurrences, but there’s not much consensus on whether they actually improve anything. A lot of them have been tested in animals, but not in humans for the purpose of reducing HSV recurrences. Others have been tested in early-stage trials with very small sample sizes and don’t achieve statistical significance, even if the results are promising: L-Glutamine Propranolol Aspirin & other COX-2 inhibitors Another link Lithium Lactoferrin and plenty more. Some people have also speculated that diet changes (ketogenic diet, intermittent fasting, etc.) also lead to dramatic improvement in symptoms. There is plenty of reason to be skeptical about these claims, especially when they only come from a small number of people. The sample size simply isn’t large enough. And, of course, there’s a new drug that we know to be a strong inhibitor of HSV replication: amenamevir. Just as famciclovir has the same effect on HSV as valacyclovir, amenamevir has the same effect on HSV as pritelivir. And, as some of you know, amenamevir is approved in Japan and can be purchased online. In many cases, valacyclovir by itself is not enough to stop all symptoms/recurrences. Additionally, valacyclovir doesn’t reduce shedding as much as it should. But research has found a strong correlation between number of recurrences and shedding. If we get recurrences down to zero, chances are that shedding is close to zero. At the very least, it means with very high probability that shedding has been significantly reduced. Clearly, to achieve a functional cure, valacyclovir is not enough. But when combined it with other drugs/supplements/diets, it could achieve a functional cure or at least eliminate all outbreaks (which all but guarantees a very low level of shedding). Hypothetically, valacyclovir might reduce the average number of outbreaks per year from 3 to 1. Taking amenamevir in combination with valacyclovir might reduce that number to .5. Taking glutamine with amenamevir and valacyclovir might reduce that number to .2 (this is just a hypothetical example). Many of these combos may have a synergistic effect, meaning that using both drugs together would have a stronger effect than the effects of each individual drug combined. And how will we actually figure this out? By doing our own clinical trial. We need a significant amount of participants. A trial will have at least sixty participants (more is better, but sixty is doable) for a three month period. I’ve created to gather some basic information about people (nothing personal or potentially identifying. Just things like age, time of diagnosis, frequency of outbreaks in the past year, whether or not they currently take medication. This data will help group the study participants properly) and a spreadsheet for a trial participant to record when they get an outbreak and to briefly describe the symptoms. The group will be split in half, with thirty participants taking only valacyclovir and the other half taking valacyclovir along with whatever we want to study in combination with valacyclovir. Other standard study procedures such as randomization of the groups will be incorporated into the trial. All the participants have to do is take the pills and record any outbreaks they have, briefly describe the symptoms, and write down when they are fully healed from the outbreak. At the end of the trial, we will have three months of data for sixty participants. That’s ninety months, or seven and a half years of data, in each group. If the valacyclovir group had a total of ten outbreaks, then the average number of recurrences per year would be about 1.3. If the combo group had a total of five outbreaks, then the average number of recurrences would be about .7. Finally, we test to see if the combo led to a statistically significant reduction in outbreaks compared to the valacyclovir only group. The larger the study group, the more statistically significant the findings will be, which is why a large number of participants is crucial. Finally, we finalize the trial by performing any other important data analysis. For example, we could see if there is any correlation between age and efficacy of the treatment. We generate graphs and charts and write a brief “paper” presenting the findings. The only one of these trials that would actually “cost” a lot of money would be an amenamevir trial (amenamevir, although available, is pretty expensive). However, if enough people are willing to participate in one, we could get data on what looks to be the most effective treatment that is currently available. A trial to assess the effect of any other drug, supplement, or diet would practically cost nothing. Aspirin, glutamine, lactoferrin, and propranolol are widely available and inexpensive, as are many of the other possible treatments, and these trials assume that participants are already taking valacyclovir whether it is covered by their insurance or not. And these trials do not require a major time commitment. The participant will have to verify at the beginning of the trial that they have the study drugs/supplements in their possession (just send a picture and blur out any personal info if there’s a prescription bottle). They take one or two pills a day and record any recurrences. In trials with potential side effects (e.g. lithium), the participant records any side effects. At the end of the study, the participant sends the spreadsheet over. That’s it. These studies and data may not be as high quality as that of many clinical trials, but they are certainly useful. By obtaining this data, we give ourselves the ability to treat this disease better than ever before. Instead of shooting fish in a barrel and hoping some supplement works because one person on the internet said it did or because a supplement had an effect in an animal study, you’ll be able to rely on real data from humans. Not only that, but that data will be on a combination of valacyclovir and whatever else is being taken, which there are very few if any human studies on. TL;DR: Doing crowdsourced trials on different combinations of valacyclovir and other compounds, we can see which compounds are effective for improving HSV. You can participate, and it is minimally time-consuming and costs next to nothing (unless you want to do an amenamevir trial). Participating will help us gather data to improve our conditions dramatically. If you’re interested in participating, please fill out this form: https://goo.gl/forms/Q50PKY8I11tVMsLh2 I am not interested in anyone’s personal data. These studies are to remain anonymous and I will never ask for or attempt to collect any personal data. The only reason I ask for age in the form is because is a potential variable to account for in data analysis. You do not need to provide your age if you don't want to. All communications should be done through this website’s messaging system or using an email that does not link to your identity. You can reach me at honeycombstudy at gmail.com or message me on this site. Any questions and/or skepticism are more than welcome. Finally, if anyone would like to contribute to this project please contact me! Let’s start taking action.
  6. @Micah and I are trying various ways to spread awareness and make something happen for those of us that are tired of living with herpes. Although YouTube is a good avenue to do that, we wanted to also try to write to celebrities, specifically those that do reply to fans and would possibly like to help the cause and fund herpes research. Now I wanted to ask HC members to please contribute any celebrity names that they know of who respond to fans in the comments below. *Also if you know the address of such celebrities please PM me or Micah. Thank you. Please get involved if you can as well. We need more people to try and do something and take a stance.
  7. I found a research on herpes by using crispr. You may want to take a look. https://www.sciencedirect.com/science/article/pii/S0168170216306943
  8. Wanted to post this for quite some time now but never found the right moment until now. I must have had herpes passed to me as a child because there is a photograph of me with a coldsore when I was about 10 so that really sucks! And as much as I wish I didn't have it (I really would do anything to not have it) I have actually learned more about health and well-being from it than I would have otherwise. Basically you begin to understand your immune system and learn how to tell when things are not so good (therefore making the correct adjustments to see that you are mentally and physically sound and fit). There's a Chinese proverb that goes, 'one disease long life no disease short life' and that means you sometimes need an unfortunate event to make you realise and see the bigger picture. True though, like death and family passings, always puts things into perspective. I was quite ignorant of the fact that every year or longer sometimes, I would occasionally get cold sores on my lips from ages 10 to about 22, but didn't feel socially constraint by them as I do now, I'd just accept that they come, in fact I didn't even know it was herpes as such until I started to seriously research the topic. I started seeing a girl aroun 2010 and I am unsure what made me think but I could not bare the fact that should I have an outbreak I would have to see this girl, and I think the worrying about it probably brought one on, I sort of avoided the girl for 2 weeks but in that time isolated myself in my house and I know people say you should not do that but in that 2 weeks I think I learned all I needed to know about how to combat Herpes and make sure it never came again to that severity. I eventually told her and she seemed kinda cool and just saif be careful when together etc but I was determined to avoid that situation at all cost. Those 2 weeks were hell, I think I tried every single kitchen and bathroom remedy on the internet and actually did more damage to my whole lips and mouth that I wondered if the crater i had created would ever go. I tried tea bags, salty water, honey, nail polish remover, tea tree oil, olive oil, Lysine tablets, cutting out all arginine foods and about a million others, honestly it was not good, physical and mental states were deteriorating and I could no longer do it. Three things I pulled from my research were 'IMMUNE SYSTEM', 'ACIDIC AND ALKALINE' states, 'LYSINE + ARGININE based foods' and 'PRESCRIPTION ACICLOVIR CREAM AND TABLETS. The immune system is evident, you run your body down you get ill, making more work for your immune system to try to fix, like a country being attacked from all boarders, if you have a weak immune system then it will be easy for invaders to infiltrate, a stronger immune will make it much harder. Also body is made up of trillions of cells, cells are like little soldiers, if you treat your army well, exercise them regularly, give them the right foods and let them live in the right environment then you shouldn't have anything to worry about. The acid and alkaline theory states this, any virus is incapable of surviving in an oxygen rich environment such as in an alkaline state, and eating foods high in oxygen and water 'should' push your body to a more alkaline state. Even if you don't believe in this theory, the fact is eating foods high in water, oxygen, chlorophyl, unsaturated fats, vitimins and minerals as opposed to foods that oppose this, well you run the risk of pouring a right sticky mess into your body! That's my none scientific explanation of what I took. It doesn't have to be scientific and hard to understand. And as many of you will know, foods high in Arginine are a food source for the herpes virus, so I researchd that heavily and began to eliminate accordingly. It ws quite simple as most of the arginine foods were also the least healthy in most cases (but the idea is not to be too strict with this, just trial and error some things, if they don't work try something else, eventually after a year or two you should start to see change). I soon got onto my doctor and asked to be prescribed aciclovir cream and tablets as my research had told me that these are the only over the counter meds that work, Lysine was also reccomended butit says you should take one a day minimum to prevent and to be fair I did for about 6 months then thought fuck this, I'll just clean up my body and then I won't need to be taking this as often (which I did). Even now I won't take Lysine or Aciclovir cream or tablets daily because I also read that your body can become immune so you have to save that weaponry for when it's needed. A quick look at my lifestye before I took things seriously. Meat eater. Drank coffee (with milk). Took party drugs and partied long and hard into the night and day. Had sugar in coffee and tea. No real idea of what healthy food was. No understanding of the bodies immune (didn't care either). Smoked weed now and then. Only drank water when I was hot. Not too much exercise. Ate chocolate and sweets. Allowed myself to exert my stress physically. Sounds horrible now looking at that list, but I knew I had to change some things up, this was by no means an overnight trandformation, and the research was ongoing and a developmental thing. To keep this short and as to not repeat myself, if you look at the list above of my lifestyle before I took things seriously, well I started to be the exact oppisite of all of them. Simple. Started to eat clean whole foods like legumes, rice, dark greens, basically more of a vegetarian / vegan based diet but still love thin base pizza and snacks now and then, it's just moderation. Stopped drinking so much alchohol and gradually reduced it to literally maybe one or two drinks a week, cut out ALL spirits etc, started to drink water more regular. Nothing breakthrough at all. Here's how I see it, your body is a machine, nothing more, your soul is wherever the hell it is but your body is a bio-mechanical machine that needs regular maintenance, servicing and looking after. Like a car or motorbike, if you don't put the oil in, the engine siezes, if you don't put the right fuel in, it will come to a stop, if you don't polish the body work it's going to look rubbish and so on. Your body is no different. If you treat your body like crap, when an invader tries to invade (in herpes situation travel up your nerves and attack local cells on your skin / lips / body well it will have an easy time because your 'soldiers' or cells will be fat old men who can't run or defend shit. I have not had an outbreak in nearly 2 years until 3 days ago, and that's because I let my guard down, I decided to drink on the weekend and woke up feeling really bad, and shot out of bed like lightening when i felt something on my lip. I was lucky enough to feel the first tingling and a very small bump on my lip, so ran very quicky to grab Aciclovir creme and proceeded to dab that all over, and it probably just about caught it in time, unfortunately I did not have Aciclovir anti-viral tablets to also combat this, so instead used 1000mg lysine tablets whch are no way as good, but I definitely saved it from ballooning and making a mess of me, I am hoping to be cleared in another 2/3 days. I have now decided to NEVER drink again, whereby drinking so much you don't know how you got home, sure I'll have the occassional beer but never above the drink drive limit. Sound harsh? Well I see drinking as a waste of money anyway and I would much rather be up on Sunday at 7am making memories and drinking tea than lying in bed with a coldsore for 1 week! There's probably more I could say and share on my experiences, but I seemed to have written a lot already. If you want to ask me anything feel free, but one last piece of advice I can give is what works for someone might not work for you and vice versa. It's a trial and error thing. Such as the coffee thing, some people will swear that they eat coffee beans and drink all black coffees daily and nevera thing, good for them, but I know cutting coffee out of my diet not only saved me a lot of money, made me physically and mentally healthier but I do believe it stopped the outbreaks. Plus it's a mind over matter thing also, if you don't focus on the problem it will never be a reality, you could kiss your teddybear every morning and tell people that you have not had an outbreak ever since you started kissing your teddybear, if that works keep doing it, just try not to pass such madness on as scientific breakthrough Congrats for getting this far.
  9. http://collections.plos.org/sti
  10. Hey everyone I just wanted to know your views on whether the complacency of the herpes community and its inability to mobilize is part of the reason why we have slowed progress on the cure front? Has the “skin disease” moniker actually lulled us into complacency and prevented us from asking for better drugs? or did the science just never catch up?
  11. In an effort to fight “invasive fish species”, the herpes virus is expected to wipe out the common carp. However, scientists have warned that the virus may become a major public health risk to humans too. http://yournewswire.com/australian-government-herpes-water/
  12. Looks like new STEM CELL Research is paving ways to cure all viruses, I know this is a long ways off and if it is used on humans it will be used on people with the most severe disease. As most of you should know, there will be no cure for herpes in more than 20 years, even if they found the cure today as otehr more serious diseases take priority and the drug and/or procedure must be safe, therefore it is tested on very sick people. and herpes is very low on the list. Check out this reading below: https://www.thedailybeast.com/this-doctors-revolutionary-stem-cell-treatments-could-eradicate-hiv
  13. This is interesting. Thanks to Henrietta Lacks we have been able to use and continue to use her cells (immortal cells) to study and research for vaccines such as Polio, herpes, cancers, and Parkinsons till' today. Her Human Papilomavirus's (HPV) cancer genes turned on her oncogene to produce indefinite number of cancerous cells.
  14. Interesting: https://en.m.wikipedia.org/wiki/Herpes_simplex_research
  15. https://www.nih.gov/news-events/news-releases/nih-study-glutamine-suppresses-herpes-mice-guinea-pigs
  16. I know most people aren’t willing to put themselves out there when it comes to letting people know the reality of herpes, which isn’t the mellowed out version that the media spits out. I know it’s difficult because we all just want to be pain free and/or cured of this virus without letting everyone see we might be victims of this indiscriminate, lifeless set of proteins. I want to ask, though, wouldn’t it feel rewarding if you were involving yourself even in a minute manner to let more people know about the seriousness of the very thing that affects us and millions of new people every year? Please give me your opinion on this, but I wanted to propose a flyer or mini posters that could be handed out to people and it would have brief, but impactful words or statements on HSV, the number of people affected, and how it’s not tested for. I will make the flyer myself and show it to those who would be willing to print out copies of it and put them up at local universities or anywhere it would be legal and appropriate and also hand them out to people. I will need more people than just myself doing this if we want to spread the word to as many people possible. So please PM me or let me know on this thread if you want to help. P.S. I used to intern at a medical health education center and I have good relations with the director of the program who tries to help raise awareness for health issues, diseases, etc. I will be meeting her next week and try to discuss this or any better ways to help.
  17. I want to reserve this topic as a humorous/sarcastic corner to sort of see how many things users can find online that had a crazy amount of funding or used tax payer money, which could’ve been used instead for things like research, cures, awareness related to diseases or serious medical problems. Hopefully it’ll be a way to just blow some steam at things we’re not very happy about or find funny. I’ll start: This is just unneccessary and the money could easily have funded research for HSV or helped people that are homeless or even helped Texas get a better sex-ed program
  18. Looks like things are progressing well for what seemed to be incurable diseases, so hopefully that includes HSV and in far less time! Biotech Expert Claims That “In the Next Decade, Most Cancers Will Be Curable” October 25, 2017 Synthetic biology is going to revolutionize our world https://futurism.com/videos/biotech-expert-claims-next-decade-cancers-curable/?utm_content=buffer71a78&utm_medium=social&utm_source=facebook.com&utm_campaign=buffer
  19. Exploring how herpes simplex virus changes when passed between family members October 20, 2017 A new study explores how herpes simplex virus might change when passed from one individual to another, information that may prove useful in future development of therapeutics and vaccines. This rare glimpse into a transmission event reveals nearly perfect genetic transmission of the virus from a father to his son and lays the foundation for future studies exploring the genetic diversity of this virus. A paper describing the study appears online Oct. 20 in the journal Scientific Reports. “Millions of people worldwide have herpes simplex virus,” said Moriah Szpara, assistant professor of biochemistry and molecular biology at Penn State and an author of the paper. “We see locally distinct variants of the virus with distinct genetic fingerprints in different regions around the world, and, with the prevalence of international travel, we’re starting to see a lot of different variants of the virus appearing in one place. This could have implications for how the virus evolves and how we design therapeutics to combat it. Studies of a related virus — human cytomegalovirus — suggest that the virus diversifies after transmission, and we wanted to see if this was also the case for herpes simplex virus.” Herpes simplex virus type 1 (HSV-1) is a highly contagious infection that commonly causes oral and genital lesions. More severe symptoms can also occur, such as eye disease and, in rare cases, encephalitis -- inflammation of the brain that can cause flu-like symptoms, confusion, seizures, or problems with movement. Although some medications can reduce the severity and frequency of the symptoms, there is no cure for HSV-1 and no guaranteed way to prevent transmission. HSV-1 can be transmitted through contact with sores or saliva around the mouth — as is often the case in familial transmission — or sexually. “Capturing transmission of herpes simplex virus is incredibly difficult,” said Szpara, “in part because the social stigma associated with having the virus makes it unlikely for sexual partners to admit when they transmit it. The virus also lasts a lifetime. Unlike the flu, which comes and goes, HSV remains in an individual’s body for the remainder of their life. Periods of latency and reactivation make it hard to know exactly when the virus was first transmitted.” “In this study, we had a known case of familial transmission,” said Nancy Sawtell, professor at the Cincinnati Children’s Hospital Medical Center and an author of the paper. “Samples from a father and son were cultured in the lab, enabling us to investigate potential differences of the virus after transmission. To gain a comprehensive look at the results of transmission, we used genetic sequencing, and we examined each virus in an animal model to compare the level of virulence, or the ability to cause disease. Animal models have the ability to reflect the interactions of all the body’s systems at once — the outer surface, the immune system and the nervous system all interact during the response to herpes simplex virus infection.” Genetically, the viruses taken from the father and son were a near-perfect match. The viruses also had similar pathology when tested in mice — they grew at a similar rate and had a similar ability to set up long-term infection in the brain. Although the viruses from the father and son were not completely identical, these results suggest that HSV-1 may not change much when transmitted between closely related individuals. However, the researchers suspect that transmission between unrelated hosts may provide a more dramatic opportunity for change. “An individual’s immune system exerts selection pressure on a virus,” said Utsav Pandey, graduate student at Penn State and first author of the study. “The son got at least half of his immune system from his father, so it was probably a similar selective environment. Unrelated individuals likely differ more in their immune system, which could shape the virus.” The research team also compared the performance of the viruses from the father and son to two separate clinical cultures of HSV-1. The variants from the father and son were less virulent — less severe — when tested in mice. Additionally, the genome sequence of the viruses in the father and son, who were from the United States, did not fit in as expected with other HSV-1 genomes that have been genetically sequenced from the United States or Europe. “This study broadens our knowledge of what herpes simplex virus variants are circulating in the U.S.,” said Szpara. “It’s not just the United States/European variants that are used in vaccine development and clinical studies. When we think about designing therapeutics and vaccines, we need to know how the virus can differ or we may design something that only controls the virus from a particular region.” To further understand how genetic diversity of HSV-1 is generated, the researchers plan to turn their attention to studying transmission of the virus between unrelated individuals. “If we could understand how much the virus changes when passed between unrelated individuals and how the virus’ genetics influences the level of virulence or level of harm the virus can do,” said Szpara, “then hopefully we can design better treatments for HSV-1.” In addition to Szpara, Sawtell, and Pandey, the research team includes Daniel Renner, computational scientist at Penn State; and Richard Thompson, professor of molecular genetics, biochemistry, and microbiology at the University of Cincinnati. The work was funded by the National Institutes of Health and the Pennsylvania Department of Health Commonwealth Universal Research Enhancement (CURE) program and supported by the Huck Institutes of the Life Sciences at Penn State. http://news.psu.edu/story/489409/2017/10/20/research/exploring-how-herpes-simplex-virus-changes-when-passed-between
  20. More CRISPR use for HIV...which can only lead to helping the people with HSV soon... “It’s like hiding a book in a stack at the library, and the book has instructions to build a nasty bomb. To get rid of that information, you need to get it back out of the library. We’ve never had the technology to do that inside the living cell until CRISPR came along. It’s the first efficient way to do that inside living cells.” http://m.sfgate.com/business/article/How-CRISPR-gene-editing-tech-can-fight-HIV-12294985.php How CRISPR gene-editing tech can fight HIV Oct 21, 2017 Researchers at UCSF have received a three-year, $1.6 million grant to advance their work using novel gene-editing technology to make human blood cells less susceptible to HIV infection. The grant, from biopharmaceutical giant Gilead Sciences, a global leader in sales of HIV treatments, will fund a team of scientists working to modify the DNA of a type of white blood cell to make them immune to HIV infection. The cells, called T cells, have long been a focus of researchers seeking to improve HIV treatments. T cells help the immune system fight many diseases, including some cancers and flu viruses. They play a unique role in HIV because the virus targets and destroys T cells, and HIV-positive patients whose T cells become too depleted by the virus will progress to AIDS... ...It is the first research initiative that Foster City’s Gilead, through its philanthropic program, has funded that involves using CRISPR as a tool in HIV cure-related research. While $1.6 million is not a huge amount, it comes with fewer restrictions than many government grants. The grant will fund a team of five researchers for three years.
  21. So here’s something new and interesting. It’s not directly herpes related, but was wondering if it could be implemented in future drugs and therapeutic vaccines for herpes? One vaccine injection could carry many doses Microparticles created by new 3-D fabrication method could release drugs or vaccines long after injection. MIT engineers have invented a new 3-D fabrication method that can generate a novel type of drug-carrying particle that could allow multiple doses of a drug or vaccine to be delivered over an extended time period with just one injection. The new microparticles resemble tiny coffee cups that can be filled with a drug or vaccine and then sealed with a lid. The particles are made of a biocompatible, FDA-approved polymer that can be designed to degrade at specific times, spilling out the contents of the “cup.” http://news.mit.edu/2017/one-vaccine-injection-could-carry-many-doses-0914
  22. So there’s enough funding and focus already on completely eliminating getting sick from the flu again, which helps make money every year through flu shots and pills, but not $10 million for companies like Aurx and others that are trying to prevent a silent epidemic from taking over everyone’s lives?! http://newatlas.com/universal-flu-vaccine-human-trials/51606/
  23. Hello all! I'm back with more questions regarding a full cure. In 2008, Cullen made headlines and projected 10 years until the mircoRNA drug was made available. Well, we are coming up on the 10 year mark. My questions: Is the approach that was mentioned in 2008 dead in the water? Are there any other researchers looking to get the virus out of latency and flood it with antivirals? What's current with Cullen and Bloom, besides the work with Editas? Thank you in advance for your responses, Yammy
  24. HelpMePlease4444

    Dr Bloom

    When does Dr Bloom intend to bring out his results with regards to the animal studies using CRISPR to treat Herpes?
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