Sign in to follow this  
Followers 0
itscuretime

HELP Funding Duke Research!

67 posts in this topic

I wrote an e-mail to Bryan R. Cullen, Ph.D.

Department of Molecular Genetics and Microbiology

Director, Duke University Center for Virology

He is the one who over-saw the research done this year. I inquired about how the public could help fund his research, and here was his response:

"Dear Mr. xxx,

Thank you for your interest in our research. As there have been many

enquiries as to how this progressing, I have drafterd a general statement

of where we are at this point (see below). Although I am encouraged by how

things are going, it will undoubtedly be years before we can proceed from

animals to clinical testing in humans and this will require extensive

funding. Therefore, I am grateful for your interest in helping to support

our research and I will pass your name on to the responsible individual

here at Duke. Hopefully, you will be contacted soon.

Best wishes,

Bryan R. Cullen, Ph.D.

We have received a considerable number of e-mails that have asked questions

about the report we recently published in the scientific journal "Nature."

This report received extensive press coverage, some of it misleading. We

will briefly answer some of the most common questions that we have been

asked, and particularly how our work relates to a new treatment for cold

sores, caused by Herpes Simplex Virus 1 (HSV-1), or genital ulcers, caused

by the related but distinct HSV-2. We also attach the press release issued

by Duke University Medical Center, which was the basis for all the press

reports.

1) What have you accomplished?

Our work provides, for the first time, a molecular understanding of how

HSV-1 establishes a life-long latent infection in the nerve cells of the

face, and how it reactivates from latency to cause cold sores.

2) Have you developed a new treatment for cold sores?

The work we have performed provides a basis for the development of

anti-HSV-1 drugs that might be able to permanently clear HSV-1 from

patients.

3) Are these drugs being used on people?

No, we are currently initiating trials in mice to study efficacy and

toxicity.

4) When might this drug reach the clinical trial stage?

We anticipate approximately 2 years of animal experiments in mice followed

by approximately 1 year of toxicity studies in other animals, followed by

small studies in healthy volunteers. After that, assuming things go well,

this drug might proceed to clinical trials in HSV-1 infected individuals.

It is very possible that the drug candidate might fall out at any of these

stages, due to lack of effectiveness or some unanticipated side effect.

5) How does this relate to HSV-2, which causes genital herpes?

All our work so far has been on HSV-1, the cold sore virus, but HSV-2 is

quite closely related. We have begun work to see if the lessons we have

learned in HSV-1 also apply to HSV-2, and should know this by the end of

the year. If these lessons do hold, then we might hope to start animal

trials for an anti-HSV-2 drug in early 2009. However, our initial data

indicate that HSV-1 and HSV-2 will require distinct drug therapies.

6) What can I use to treat chronic HSV-1-induced cold sores or

HSV-2-induced genital ulcers now?

All treatment decisions should be made in consulation with your physician,

and no general guidelines will apply to everybody. While there are no drugs

that attack latent herpes viruses, three closely related prescription drugs

(Zovirax/acyclovir; Famvir/famciclovir and Valtrex/valacyclovir) are potent

inhibitors of active virus that work quite well and that you might discuss

with your physician.

We hope this information answers your questions and is helpful. Please be

assured that we are continuing to work on the problem of developing novel

HSV-1 and HSV-2 treatment approaches.

Sincerely,

Bryan R. Cullen

Jennifer Lin Umbach"

I will keep you updated on whether I am contacted by the person who is in charge of the funding, as I should be contacted soon.

:)

Share this post


Link to post
Share on other sites

This stuff from Duke seems a while away. Three years till it even really starts I think. But it also seems the most promising as an actual cure.

Has anyone heard any news since last year about it?

Or does anyone know any way to help fund this?

This doctor would instantly become my own personal hero if he suceeded in this.

Please post if you know of any more recent info on this.

Share this post


Link to post
Share on other sites

Also if anyone heard back about how to donate?

Share this post


Link to post
Share on other sites
Also if anyone heard back about how to donate?

Wondering,

If we don't hear back from anyone on the forum, would you be willing to send a letter or email to duke to ask them about their progress and how to donate? I'd be willing to donate to them in addition the the UF (and Harvard, when I get some more cash flow).

Share this post


Link to post
Share on other sites

Yes. If we dont hear anything in a couple days, I will send them an email and post what I hear back.

Six weeks ago, I had never even thought about herpes, now I would trade everything for a cure.

Perspective sure does change things.

I am shocked we aren't closer to a cure now.

Share this post


Link to post
Share on other sites

here is the Duke info...

I wrote to Dr. Cullen (Duke), Dr. Knipe (Harvard) and Dr. Bloom (UF) -- just to ensure we had the correct/approved info for the donation choices motorcyclemaintenance generously posted on his site, www.herpesisnormal.com. I have heard back from all of them; here is the info I received from Duke just this past week:

Duke

Brief Description of Research

Herpes simplex viruses--both the oral (type 1) and genital (type 2) varieties--hide from the immune system and from current antiviral drugs by hiding in nerve cells in an inactive "latent" form. Researchers at Duke University are developing a novel approach that they believe will force the virus out of this latent state and allow it to be immediately killed by existing drugs.

Links to Technical Research

http://www.time.com/time/health/article/0,8599,1819739,00.html?xid=feed-cnn-topics

http://localtechwire.com/business/lo...story/3181677/

http://www.nature.com/nature/journal/v454/n7205/full/nature07103.html

Point of Contact for the Research

Christy Krupa

Dept. of Molecular Genetics & Microbiology

Box 3025

Durham, NC 27710

christine.krupa@duke.edu

How to Donate

Making a gift to support Dr. Cullen’s research:

Online: https://www.gifts.duke.edu/

2/3 down the page there is a text box where you can type designation comments. In this box type: Professor Bryan Cullen account 391-1628. All gifts designated for this account must be credited to this account!

Mail: Alumni and Development Records

Duke University Box 90581

Durham, NC 27708-0581

Phone: (919) 684-2338

Fax: (919) 684-8527

In the memo line of the check, please write: Professor Bryan Cullen 391-1628.

Share this post


Link to post
Share on other sites

Thank you for the donation information.

I just made a donation of 33 dollars to them.

I will do so every month. More if I can.

Is anyone keeping a tally of Duke donations?

I fear our means are too small to make more than a symbolic gesture, but if enough of us donate to these schools, that gesture really will get us a cure sooner. And if someone has enough money, please consider larger dedicated donations to these schools HSV research programs.

This Duke research is actually a cure, already for HSV 1, and soon after I assume HSV 2. It just needs the research to prove effective and safe. But I want to support it heavily because it is designed to be a cure (actually ridding the body of this hellspawned virus).

Share this post


Link to post
Share on other sites

Duke fund tally

Hi Wondering 333:

I don't think anyone is keeping a tally for Duke. Would you be interested in doing it? I started the tally for U of FLorida and someone else started one for Harvard.

I wonder if we could put a Tally for all three in one spot. That would make it easy wouldn't it?

Best regards.

Share this post


Link to post
Share on other sites

I think that would be a great idea.

I am happy to start a thread for Duke, and then update it as people post to it, but maybe I should wait and we can get one going with numbers for all three.

Share this post


Link to post
Share on other sites

I dont understand Dr. Cullen theory fully - how can it be assured that all virus will come out if the machanisme that makes it hide is taken out?

if just one thread stays in the spine we are nowhere...

Maybe somebody can explain how all virus is to come out in the open....

Share this post


Link to post
Share on other sites

I am definitely not a scientist, or even that scientifically minded, but my understanding is that it should force it ALL out of hiding then your body with the help of antiviral meds can kill it off. Assuming some is not forced out of hiding you would go through the process again several times until you got it all, or in worst case you would get most of it, be OB free for several years, then do it again if something slipped through.

I think naturally the virus always wants to come out in the open, but some kind of protein forces it not to. The Duke method will get rid of or disable those proteins that make it hide. So if all of that protein can be disabled then all of the virus will come out.

Maybe someone knows more about it than me though. I only know what I have read so far.

Share this post


Link to post
Share on other sites

Hello itscuretime and solvingtheproblem,

Thank you for your posts, you have given me hope. Although Dr. Cullen's replies state that a cure is at least a few years away, there is definitely light at the end of this dark tunnel. It may be too much to ask but have either one of you thought of contacting celebrities for donations? I feel like you're my saving grace right now. I've had an extremely difficult weekend not because of myself but I saw a sore on my young son's lip yesterday and it broke my heart. He's always on me and kissing me and since I was diagnosed with HSV-2 two years ago, I never thought anything about giving my baby any kisses. I guess I was wrong. Recently I've had an outbreak on my leg and it freaked me out completely. I can pretty much deal with being infected but not my baby, not my heart. He does not deserve this because of one mistake that I made. He hasn't been to the doctor yet but I am sure that its herpes and I've had to keep myself from breaking down. I will be donating to Dr. Cullen's research on Tuesday morning and have also tried to set up a myspace page to raise awareness about the need for donations but I don't think I'm strong enough to continue with it. My apologies for rambling on but it's been a rough couple of days. Anyway, back to my original question, do you think contacting celebrities will help with donations? I know herpes is not something that they would be happy to speak about in public but if it assists in raising awareness and money, don't you think its worth a shot?

Again, thank you for all your posts!

Share this post


Link to post
Share on other sites

Hi JuneSucks,

Dont despair we are in this together. Have faith in God. He will helps us get better

Share this post


Link to post
Share on other sites
Hello itscuretime and solvingtheproblem,

Thank you for your posts, you have given me hope. Although Dr. Cullen's replies state that a cure is at least a few years away, there is definitely light at the end of this dark tunnel. It may be too much to ask but have either one of you thought of contacting celebrities for donations? I feel like you're my saving grace right now. I've had an extremely difficult weekend not because of myself but I saw a sore on my young son's lip yesterday and it broke my heart. He's always on me and kissing me and since I was diagnosed with HSV-2 two years ago, I never thought anything about giving my baby any kisses. I guess I was wrong. Recently I've had an outbreak on my leg and it freaked me out completely. I can pretty much deal with being infected but not my baby, not my heart. He does not deserve this because of one mistake that I made. He hasn't been to the doctor yet but I am sure that its herpes and I've had to keep myself from breaking down. I will be donating to Dr. Cullen's research on Tuesday morning and have also tried to set up a myspace page to raise awareness about the need for donations but I don't think I'm strong enough to continue with it. My apologies for rambling on but it's been a rough couple of days. Anyway, back to my original question, do you think contacting celebrities will help with donations? I know herpes is not something that they would be happy to speak about in public but if it assists in raising awareness and money, don't you think its worth a shot?

Again, thank you for all your posts!

Dont be so hard on yourself, you probably did not give your child herpes. take him to a doctor to get it swabbed if you are concerned, however kids are pretty susceptible to HSV-1 infection cause of playing with other kids and putting things in their mouth. If you have genital herpes, its pretty unlikely you transmitted it to your sons MOUTH

Share this post


Link to post
Share on other sites

I recently had the pleasure of speaking with dr cullen this week. He basically told me that the research timeline of 2-3 years for the people clinical trials are dependent on funding which he needs for the toxicology studies. And if all goes well with the progress following the toxicology studies. He said that he would like to put up a website to interact with the community to keep people in the loop about the research progress. Let's hope he gets adequate funding so we can hopefully get rid of hsv.

Share this post


Link to post
Share on other sites

h

hey. this sounds the most promising research out there to be honest. can it really kill off the WHOLE virus?

how did you speak to him unlucky? if it is a cure then we can't let it go to waste due to funding.

this guy could well earn himself the noble prize if he can cure this oldest known human virus.

how can i help out with a donation via paypal? i dont live in the US nor do i have a credit card.

please reply. thank you

Share this post


Link to post
Share on other sites
He said that he would like to put up a website to interact with the community to keep people in the loop about the research progress.

Did you direct him to post at this forum? I know Bill Halford had made some postings on the HHP forum in the past. We'd certainly love to hear from him.

Share this post


Link to post
Share on other sites

how can i help out with a donation via paypal? i dont live in the US nor do i have a credit card.

You can send a check in the mail, I assume international money order would probably work too.

Alumni and Development Records

Duke University Box 90581

Durham, NC 27708-0581

Phone: (919) 684-2338

Fax: (919) 684-8527

In the memo line of the check, please write: Professor Bryan Cullen 391-1628.

Share this post


Link to post
Share on other sites

yes i would love to hear him on this forum very very much too.

i wiki'd international money order and its like trying to decifer hyroglyphics. i am young and naive and in too much pain to get to the bank and unfortunately lost my internet banking stuff if i ever had one. not trying to be a pain, but paypal method of donation would be a very accesible and discreet addition. pleazy

when was the last posts on this stuff? anyone still in touch with him? i think i emailed him a while ago but just got some confusing and unrelated , probably auto-mated reply from a secretary maybe.

how and when did you speak to him unlucky? :-)

Share this post


Link to post
Share on other sites
Did you direct him to post at this forum? I know Bill Halford had made some postings on the HHP forum in the past. We'd certainly love to hear from him.

I encouraged him to do so. he is in the process of setting up his own website so that the public can be kept informed regarding this very promising research.

Share this post


Link to post
Share on other sites
yes i would love to hear him on this forum very very much too.

i wiki'd international money order and its like trying to decifer hyroglyphics. i am young and naive and in too much pain to get to the bank and unfortunately lost my internet banking stuff if i ever had one. not trying to be a pain, but paypal method of donation would be a very accesible and discreet addition. pleazy

when was the last posts on this stuff? anyone still in touch with him? i think i emailed him a while ago but just got some confusing and unrelated , probably auto-mated reply from a secretary maybe.

how and when did you speak to him unlucky? :-)

i spoke with him 2 weeks ago approximately. and i simply called his office.

Share this post


Link to post
Share on other sites
Did you direct him to post at this forum? I know Bill Halford had made some postings on the HHP forum in the past. We'd certainly love to hear from him.

If he puts a post on this site, what difference will it make? What will it accomplish? Have you tried to contact him on your own time? Have you even tried to contact any of the researchers to talk to them about their research?

So many questions.... Hmmmm.... Can you answer any of them?

Be proactive...... Make a significant contribution to the HSV community.

Share this post


Link to post
Share on other sites
Did you direct him to post at this forum? I know Bill Halford had made some postings on the HHP forum in the past. We'd certainly love to hear from him.

frankly with the way some on the forum speak of him not being honest about his being a "cure" and about his timeline, im not sure he would like some of the things that he would read.

Share this post


Link to post
Share on other sites

.

hey, in the research he says that genital herpes is harder than hsv1 and we may have to take aciclover on a regular basis it says. does that mean for lifetime?

or just for a month or so to kill the virus off for good?

is this only a cure for hsv1 then?

will he mind if i call him and ask?

Share this post


Link to post
Share on other sites
If he puts a post on this site, what difference will it make? What will it accomplish? Have you tried to contact him on your own time? Have you even tried to contact any of the researchers to talk to them about their research?

So many questions.... Hmmmm.... Can you answer any of them?

Be proactive...... Make a significant contribution to the HSV community.

I dont even understand the context of your response. Unlucky said he wanted to create a website to communicate with people interested in his research. Well, we are here interested, so certainly he can post here to communicate with us.

I have tried several times to contact researchers from UF to get some further information on their research and received not so much as a form reply.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
Sign in to follow this  
Followers 0

  • Latest Buzz

    • crookbristi
      Hi @Blahdittilyblah It's definitely a very hard and awkward situation. What I find myself now doing with people/friends that make fun of Herpes is launching into a whole speech about statistics. lol.  That throws the person waay off and I eventually hear 'I didn't know any of that' or 'you mean it's possible you and I could have herpes?' and I always respond with 'yep, we both could and you wouldn't even know it.'  This helps twofold for me 1. People don't like to hear someone lecture them when they are trying to be funny so they will never joke about it in front of me again  2. I've now educated them on H and will hopefully make them aware they need to actually get tested for it.  To the second part of your post.. I would say your friend should at least find a counselor or H support group to speak with about her diagnosis. While it's awesome you are there to support her, you can't be her only source of help.  It will eventually wear you down and prevent you from coping with your own diagnosis. There are a lot of H groups out there (especially in major cities) or recommend her coming to this forum. We are a great bunch here and would love to offer our support to your friend too    
    • crookbristi
      Great post!  Thank you so much for sharing! I wish I could give everyone on this site a giant hug and tell them they are beautiful and worthwhile regardless of having H  
    • thebear123
      Dang that must be what I have then. You must've swabbed it to confirm it was HSV, huh? Is it 1 or 2?   Do you have any photos? I tried to take one of mine but my camera phone doesn't pick up the detail well.
    • thebear123
      Could you please describe how it presents itself on both your face and genitals? Both the feeling and look?
    • crookbristi
      Really?!  I was thinking about applying it to the spot on my scalp.. I did just get some new hair conditioner that's infused with mint and tea tree oil and have been putting it right on my spot; it seems to be less itchy and has gotten smaller.   I'm gonna try the tea tree oil on it tonight before bed. I bed it burns like a mother though!  
    • LiveLife100
      HSV1 and HSV2 can be in either location although HSV1 prefers oral and HSV2 prefers genital. A large percentage of new genital herpes cases are in fact genital HSV1 transmitted through oral sex by a partner with an oral HSV1 infection. The other way around (transmission of a genital HSV2 infection to a partner's mouth to become oral HSV2) is very uncommon although technically possible. 
    • redhead71
      I had my first ob 3 weeks ago which is how I found out.  My doctor took a swab from the area. it tested positive for hsv2 and negative for hsv-1.   I read on the cdc website that it can be transmitted orally and it's very confusing because the info provided isn't specific to 1 or 2.  I just want to make sure I'm getting the right info
    • Motherhen32
      I had the swap testing done.. yes we had both I wasn't thinking of anything about it knowing we've been together for so long I don't keep track of our sexual activities 
    • WilsoInAus
      You are right in that contact with your genital area is required for there even to be a chance of transmission. What testing showed positive for you, did it indicate an older infection?
    • WilsoInAus
      Hi @Motherhen32 just a few thoughts that may help. First, how did the diagnosis come about, did you have a swab and blood test and what were the results? Do you have vaginal sex and/or receive oral sex in the week before the lesions appeared? It is important to know that your partner may very well have had herpes long before any relationship with you. The fact that you have just been infected is alone not a cause to question fidelity. Talk to your doctor about options, including taking antivirals for the remainder of your pregnancy.
  • Featured