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A Christmas Round-Up of A Couple of Treatment Programs in Development

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Not much but maybe a couple of emails sent their way could be shed some light...

Juvaris -- http://www.juvaris.com/products.html

Juvaris Products

Juvaris' proprietary technology platform is broad-based with wide ranging human and veterinary applications in the treatment and prevention of cancers as well as bacterial, viral, fungal and parasitic infections. The following is a summary of the major markets with significant unmet clinical needs where Juvaris technologies are believed applicable:

Infections caused by Herpes and human immunodeficiency virus (HIV) are currently treated with products with annual sales of $600 million for Herpes and $5 billion for HIV, respectively, providing a market opportunity for Juvaris immunotherapeutics. These projects will be supported by grants and/or co-development agreements.

Lumavita AG -- http://www.fiercebiotech.com/press-releases/new-biopharmaceutical-company-lumavita-ag-created-switzerland-series-financing-chf18m

Lumavita AG is focused on worldwide development and commercialization of innovative treatments for infectious diseases in women's health. The Company's product portfolio includes FemiFect® (pentamycin) a polyene macrolide with a unique spectrum of coverage for the treatment of vaginitis, and SPK-601, a first-in-class PCPLC inhibitor for the potential treatment of infections caused by Human Papilloma Virus and Herpes Simplex Virus.

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interesting, curecomingverysoon,

Thanks for digging this up. There's also been a small development announced today by a team researching how a virus works:

"Researchers have discovered the atomic structure of a powerful "molecular motor" that packages DNA into the head segment of some viruses during their assembly, an essential step in their ability to multiply and infect new host organisms. The researchers, from Purdue University and The Catholic University of America, also have proposed a mechanism for how the motor works..."

"Because herpes and other viruses contain similar DNA packaging motors, such findings could someday help scientists design drugs that would interfere with the function of these motors and mitigate the result of some viral infections."


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Oh, and it looks like Lumavita AG's SPK-601 is already in Phase one trials:




SPK-601 is a PC-PLC inhibitor aimed at treatment infections caused by the human papillomavirus and the herpes simplex virus. Discovered at the German Cancer Research Center in Heidelberg, Germany, SKP-601 has a "host cell-based mechanism of action," Benedict said, and is designed to work by blocking both viral DNA replication and viral gene expression through the inhibition of PC-PLC.

The drug is believed to offer three significant benefits: It produces only a mild inflammatory response, which means it might be useful in treating lesions, even when administered in late-stage disease; it prevents viral replication; and its broad-spectrum activity means that it might have potential beyond the initial indications. It's possible that SKP-601 might be useful in hepatitis C, flu (including the H5N1 strain) and HIV, Benedict said.

The product is in a Phase I trial in HPV. "We hope to have a readout of that trial by the end of 2009," he said, which likely will coincide with expected data from the Phase IIb pentamycin study."

And in case anyone was wondering what a PC-PLC inhibitor is. It's a: Selective competitive phosphatidyl choline-specific phospholipase C inhibitor.

Hope that clears it up ;)

It's the first time I've heard of this particular approach.

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Fascinating! Thank you for adding, mm. This is the sort of thread that I love, where people keep adding their knowledge and building the pool of information available! I just Lumavita an email inquiring about their trials and hopefully they will get back to me.

Maybe it's the way that I'm reading it but will this one drug work for both HPV and HSV?

Here's to a future 0% transmission possibility, everyone...

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    • BioHacker
      Meds and condoms is really all you need. Statistically, HSV2 is so widespread because 80-90% of  people who have it are unaware that they have it, and so they don't take all recommended precautions (including using condoms). Oddly enough, if you were to replace your HSV2+ girlfriend (aware of HSV status, using condoms, using suppressive meds) with the average American woman (unaware of HSV status, but 25% risk, which is average - and using condoms at all times, since presumably you could insist on it), you would actually NOT reduce your risk of HSV2. The statistical risk would be approximately the same for both theoretical girlfriends (about 0.7% per year assuming sex 2x per week). That is a bit simplistic, because maybe you could decide to date only women who are verified virgins (essentially no risk), or maybe "below average risk" in some way (younger than average, fewer prior partners than average, etc.), or you could have all prospective girlfriends IgG blood tested for HSV as a condition to dating them (or having sex with them), which would reduce the risk significantly (especially if you confirmed the paperwork), but not completely (since antibodies take some time to develop). At some point, beyond-standard precautions become inconvenient and not worth the hassle (or risk of being perceived as paranoid). The risk isn't zero, and probably would never be zero, short of taking extreme measures. Efforts to reduce risk beyond standard practices, which already reduce risk to relatively low levels, are naturally subject to the law of diminishing returns. Accepting some level of risk is (unfortunately) part of the deal in most reasonable endeavors. Also, there is statistically a greater likelihood of two people passing HPV between them one way or the other, than HSV2 (assuming all recommended precautions are being taken). Of course, you could get the HPV vaccine (everyone should!). But the vaccine only covers 10-15% of the types of HPV that are out there. And tests for HPV are imperfect, and generally not available for males. And HPV (some types) can cause cancer (cervical, penile, and throat - maybe others). So, keep that in mind as well. And then, of course, there are all the other risks . . . Best not to be paranoid though . . .
    • WilsoInAus
      That’s correct. HIV is a distinct virus. No virus morphs into another one.
    • WilsoInAus
      Hey @thebrightsidegirl I hope you’re going ok, I’ve read your posts and will see if I can draw some threads. I see that you have genital HSV-1 and your partner has oral HSV-1. I’m not sure if he has tested but given it’s somcommon there’s no reason to disbelieve that’s what he has. This is the best concirdant scenario you can hope for in a sexual relationship. You both already have the virus and your immune systems are established and your experience with herpes is your own. You cannot induce an outbreak in each other by virtue your own HSV-1 and transmission to a new location on your partner is too small to worry about. If HSV-2 is present, then it needs to be brought to the relationship. It’s not at all likely you have it given you were infected genitally with HSV-1.  I suggest these symptoms are very unlikely to be related to herpes at all. If they are, then it’s far more likely to be a recurrent outbreak issue with your HSV-1 as opposed to an initial infection with HSV-2. 
    • hopeing
      Ozone is basically toxic to humans at high levels. Its probably as likely to kill your cells as the virus. Add to that the virus is not in the blood and I'd say this 'treatment' is probably totally ineffective and if it does include high levels of real ozone likely dangerous. https://en.wikipedia.org/wiki/Ozone_therapy
    • thebrightsidegirl
      Hey Wilson , do you kids answering this , i was kind of worried too ? 
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