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Novartis Acquires License to Vaccine that may Prevent CMV

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This is for CMV but maybe this success will lead to an HSV-related vaccine candidate in the future.


The North Carolina-based company AlphaVax has sold the rights to an experimental vaccine it is developing for $20 million to Novartis, the multinational pharmaceutical company based in Basel, Switzerland.

Provided that the treatment with the experimental vaccine will prove efficient in clinical trials, Novartis will also have to pay extra milestone fees and royalties.

The vaccine could help prevent cytomegalovirus (CMV), a common type of Herpes virus that can cause serious complications in people with weakened immune systems – for instance, AIDS or cancer sufferers, as well as newborns.

"We are happy to gain access to a promising vaccine candidate for the prevention of cytomegalovirus infections," said Andrin Oswald, CEO of Novartis' vaccines and diagnostics arm.

The deal was announced Monday by Novartis, which is responsible for the commercialization of the drug across the world. The vaccine is expected to enter phase II clinical trials in the coming year.

Since 1997, when it was funded, AlphaVax has attracted over $125 million in grants, private equity and other funding. The company that has bought the rights to the experimental drug will develop it through early-stage human trials.

According to Novartis, almost 80 percent of people in the U.S. carry CMV by the time they reach adulthood. Usually, they don’t feel any symptoms, but some of them may experience low fever, fatigue or enlarged lymph nodes.

Cytomegalovirus is present in body fluids (such as urine, saliva and semen) and can be transmitted via kissing, sexual contact, the sharing of food or from mother to fetus.

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I love when you hear about something new, and to your suprise its already well on its way to being availiable..

Especially because the the CMV virus can cause blindness, this is awesome. And yes, if it does work maybe this vaccine will help in the understanding on how to make a herpes vaccine work.

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      Hey all! I’m new and my diagnosis is pending. I’ve done so much research that I have a new understanding and respect for people living with herpes. That being said it wasn’t like that alway, I had been a part of a stigma we all know very well up until my latest annual pap. So I went in and had my pap and just a routing std check. Two days later and my OB calls and says everything’s good on the pap and the bloood work came back but there’s an acute result for herpes. Although he states he doesn’t know which kind or where and to come back in 6 weeks. So me being the 22 yo uneducated student, freaks out. I am asymptomatic and at the time he advises to check around my mouth and lips for any cold sores. I had a minor canker sore like lesion on my gum above my tooth and that was it super minor discomfort. So I went into a care now and the doctor did a pcr swab of the cut and another igm and an igg. So it’s about 5 days waiting period and during that time I get sick, similar to pharyngitis ( it was so bad I went back, the doctor gave me  Valacyclovir in case it was an outbreak). So now I really am thinking ok this is most like HSV-1 being it’s possible but less likely to be HSV -2 And I have zero symptoms on my genitals unless it’s dormant. And then plot twist, I get all results back, second igm, viral swab, and igg and all negative! What is going on? 
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