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curecomingverysoon

Novartis Acquires License to Vaccine that may Prevent CMV

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curecomingverysoon

This is for CMV but maybe this success will lead to an HSV-related vaccine candidate in the future.

http://www.efluxmedia.com/news_Novartis_Acquires_License_To_Vaccine_That_May_Prevent_Cytomegalovirus_32285.html

The North Carolina-based company AlphaVax has sold the rights to an experimental vaccine it is developing for $20 million to Novartis, the multinational pharmaceutical company based in Basel, Switzerland.

Provided that the treatment with the experimental vaccine will prove efficient in clinical trials, Novartis will also have to pay extra milestone fees and royalties.

The vaccine could help prevent cytomegalovirus (CMV), a common type of Herpes virus that can cause serious complications in people with weakened immune systems – for instance, AIDS or cancer sufferers, as well as newborns.

"We are happy to gain access to a promising vaccine candidate for the prevention of cytomegalovirus infections," said Andrin Oswald, CEO of Novartis' vaccines and diagnostics arm.

The deal was announced Monday by Novartis, which is responsible for the commercialization of the drug across the world. The vaccine is expected to enter phase II clinical trials in the coming year.

Since 1997, when it was funded, AlphaVax has attracted over $125 million in grants, private equity and other funding. The company that has bought the rights to the experimental drug will develop it through early-stage human trials.

According to Novartis, almost 80 percent of people in the U.S. carry CMV by the time they reach adulthood. Usually, they don’t feel any symptoms, but some of them may experience low fever, fatigue or enlarged lymph nodes.

Cytomegalovirus is present in body fluids (such as urine, saliva and semen) and can be transmitted via kissing, sexual contact, the sharing of food or from mother to fetus.

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DGD187

I love when you hear about something new, and to your suprise its already well on its way to being availiable..

Especially because the the CMV virus can cause blindness, this is awesome. And yes, if it does work maybe this vaccine will help in the understanding on how to make a herpes vaccine work.

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    • MikeHerp
      It's not clear.  The experiments in which they inactivated 2-4% latent HSV in mice, was definitely in living mice. The research paper is very clear about that.  It appears that in May 2018, they also reported nearly 20-30% inactivation of latent HSV in living mice. It's not clear what the 90% is referring to, whether in living mice or some artificial latency model using mice sells in vitro.  I really hope that it was in living mice.  That would make sense, since the earlier experiments were in living mice.  But in any case, as you mentioned, this research is progressing very well. Let's continue to try to raise money for it.  
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