I didn't ask him to cite his sources, but he told me he'd look into it and let me know if there was anything different to report. I have to wonder if I would accept the 1:100,000 odds my doc gave me if it were related to pregnancy.
@boricacid, while true it's not the end of the world, contracting it would potentially limit any further opportunities for a relationship should this one fizzle.
This article was referenced in another thread by @Clearme but it's another positive study in terms of methods of delivery, in this case AAV. It at least shows that progress continues to be made and maybe this can be used for CRISPR someday in the near future.
Adeno-associated virus (AAV) has been shown to transduce dorsal root ganglion sensory neurons following direct intraganglionic sciatic nerve injection and intraperitoneal and intravenous injection as well as intrathecal injection. We sought to determine if rAAV vectors would be delivered to the same sensory neurons that herpes simplex virus (HSV-1) infects when applied peripherally at an epithelial surface that had been treated to expose the underlying sensory nerve termini.
We demonstrated that this method of inoculation can achieve a transduction rate of >90% of the sensory neurons in the DRG that innervate the footpad. Similarly, we showed that corneal inoculation with rAAV vectors in the rabbit efficiently transduced >70% of the TG neurons in the optic tract. Finally, we demonstrated that coinfection of mouse footpads or rabbit eyes with rAAV vectors and HSV-1 resulted in colocalization in nearly all of the HSV-1-positive neurons. These results suggest that rAAV is a useful tool for the study of HSV-1 infection and may provide a means to deliver therapeutic cargos for the treatment of HSV infections or of dysfunctions of sensory ganglia.
@TheJourney "My doctor basically told me that continuing to sleep with her, even with protection and her on a viral suppressant, is Russian roulette. "
Agreed, everyone needs to know that there is a possibility, and it does happen. However, herpes is not the end of the world by any means.
Everythinf has a cure....and just like us...it would naturally come from the dirt (natures elements)...no virus can survive in an alkaline environment..trust me...u just have to be willing to commit...
Your situation is a little similar to mine. I, too, recently met a woman who has HSV2. However, she only told me that she was HSV2 positive after we slept together, unprotected, about 6 times. And, the impetus was me asking her if she had any diseases that I should know about. I was expecting a "no", of course. Like your situation, she told me that she has had it for about 30 years, had three children, never gave it to her husband, never gave it to her boyfriends since her divorce 4 years ago, and knows from her "tingling" feeling when she will have a rare outbreak.
My doctor basically told me that continuing to sleep with her, even with protection and her on a viral suppressant, is Russian roulette. No numbers were given to me as far as odds, and nor have I been able to research any odds of contraction with these circumstances. Where did doctor get such odds?
This is from the article. I don't know much about trials, but is this statement alone not pointing to a trial being ran in the U.S.? If not, why not disclose the proposed location?
With venture capital funding, RVx has developed the infrastructure to run a Phase I Clinical Trial of its new TheravaxHSV-2 vaccine (http://rationalvaccines.com/theravax). This therapeutic HSV-2 vaccine candidate will be evaluated in genital herpes sufferers to verify its safety and explore its potential to help sufferers achieve better immune control of HSV-2 and fewer herpes outbreaks.
Varivax Vaccine update: It's been a couple of weeks and I have had one of the worst outbreaks to date. I'm hoping it is my body having something like Herxheimer reaction which means it's going to get worse before it gets better. I'll keep you posted.
Thanks for the replies.
She has type 2 which she contracted during an experiment with anal sex 20 years ago. She is on Valtrex and hasn't had an outbreak in 2 years. Since the time she contracted it, she's married for 12 years and gave birth to her now 15 year old daughter, and she tells me she has never passed it on to anyone else. (She did not contract it from her ex-husband)
I spoke to my doctor who tells me the suppressive therapies these days are so good, that statistically i have about a 1:100,000 chance of contracting it unprotected and about a million to one chance if I use condoms as long as she isn't having an outbreak.
I'm not sure I'm looking for answers here, just maybe trying to gain some understanding, including what this is like for her. She disclosed all of this to me early on in our relationship and has been very forthcoming and open so I trust her completely.