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fallfornothing

AG-707: Back from the Dead?

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fallfornothing

Antigenics released it's Q2 2009 results this morning. There was a bulletpoint about AG-707:

"Immunological testing in the Phase 1 clinical study of AG-707 in genital herpes has been completed, and final study data analysis is now in process. Results will be reported in the coming months. "

Here is the link to the full Press Release:

http://www.businesswire.com/portal/site/cnnmoney/index.jsp?ndmViewId=news_view&newsId=20090730005444&newsLang=en&ndmConfigId=1000618&vnsId=33

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Searchingforacure
Antigenics released it's Q2 2009 results this morning. There was a bulletpoint about AG-707:

"Immunological testing in the Phase 1 clinical study of AG-707 in genital herpes has been completed, and final study data analysis is now in process. Results will be reported in the coming months. "

Here is the link to the full Press Release:

http://www.businesswire.com/portal/site/cnnmoney/index.jsp?ndmViewId=news_view&newsId=20090730005444&newsLang=en&ndmConfigId=1000618&vnsId=33

Will AG-707 cure herpes?

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fallfornothing

No, not a cure, but a more effective treatment that might actually work well in conjunction with Duke's strategy of coaxing the virus out of latency. This treatment is looking to increase T-cell response when the virus is in its active phase.

According to the clinical trials site, Phase I was completed around Oct. 2008. And the Press Release indicated that they were wrapping up the initial data analysis in the next few months.

And it looks like Antigenics has redesigned their site a bit - at least the home page. It is now featuring AG-707 on the home page. A hompage revamp is generally a good sign. It means they want to look all pretty for anticipated media interest.

An additional question I would have from a technical standpoint is if it could be used as a prophylactic given the fact that it triggers an immunue response from T cells....

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Searchingforacure
No, not a cure, but a more effective treatment that might actually work well in conjunction with Duke's strategy of coaxing the virus out of latency. This treatment is looking to increase T-cell response when the virus is in its active phase.

According to the clinical trials site, Phase I was completed around Oct. 2008. And the Press Release indicated that they were wrapping up the initial data analysis in the next few months.

And it looks like Antigenics has redesigned their site a bit - at least the home page. It is now featuring AG-707 on the home page. A hompage revamp is generally a good sign. It means they want to look all pretty for anticipated media interest.

An additional question I would have from a technical standpoint is if it could be used as a prophylactic given the fact that it triggers an immunue response from T cells....

Are you saying AG-707 combined with Duke's treatment may equate to a cure?

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fallfornothing
Are you saying AG-707 combined with Duke's treatment may equate to a cure?

No, I never said the word "cure" in relation to anything. I apologize if I was unclear and perhaps implied that.

AG-707 was a topic of discussion on here for a while, but has since fallen off the radar since the last available update for it was in 2008. I was simply giving an update since there was new info. Sometimes people like new info that pertains to anything herpes-related.

I know this is not the most glamorous update, but I just thought I would throw it out there...

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redyellowpurpleblue

.

how does it work? is it a tablet?

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Guest Seatortuga
how does it work? is it a tablet?

They said an injection...but I am still confused as to what it does.

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Flystud

Why is this called a vaccine when it is really a treatment?

I have HSV1 at the moment (recent 1 month infection). HSV2 was negative on a IGG test, but will have myself retested in a couple of months again to see if I have HSV2 as well.

In the case that I do not have HSV2, would taking this vaccine prevent me from getting HSV2?

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ihaveherpes1and2

i believe they call their product a "therapeutic vaccine". I think the drug is intended to induce a strong immune response to the virus. So i think you will still be infected by the virus if you are exposed to it, but it'll just stay in your nerves cause every time the virus is activated, your enhanced immune system will kill most of them, except the originals one hiding in the nerves. It is not called a cure, i think it's because it cant induce a strong enough response so that all viruses are killed every time it is active, thus some viruses are able to retreat back to the nerve cells.

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BEAUTIFULLYDAMAGEDMAMA

Is there any way to get all of the virus out in the open and out of latency?? So that the AG-707 will kill it all at once?? Another theory, Would this vaccine then eventually kill off the virus completely the more you take it? Or does the virus replicate too quickly and we would always depend on AG-707?

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Searchingforacure
Is there any way to get all of the virus out in the open and out of latency?? So that the AG-707 will kill it all at once?? Another theory, Would this vaccine then eventually kill off the virus completely the more you take it? Or does the virus replicate too quickly and we would always depend on AG-707?

Good Questions...

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ihaveherpes1and2

"Is there any way to get all of the virus out in the open and out of latency??"

Thats the million dollar question isnt it. And AG-707 dont kill the virus, it merely enchanced our immune syst, our T-cells does all the killing. But i dont know wht kinda doses do ppl have to take if this drug is released into the market.

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    • Roja
      So you did not "just join this group".    So yeah, for everyone who is interested, I'll copy your e-mail:  "Good morning [name], The treatment for hsv from me lasts for a minimum of 3 months. The sequence of treatments goes thus 1) month 1 takes care of every symptom of hsv 2 you would ordinarily experience prior to or during an outbreak such as itchy/tingling sensation, feverish feelings and water retaining breakouts. 2) month 2 is the full body flush also done with one of my remedies which is pleasant tasting and calming to the body. This dislodges the virus from whatever nerve endings it has gone into and causes a weakening of the cell membrane in its envelope stage. 3) month 3 is a repeat of month one plus extra. The virus is killed off after the once impossible to penetrate cell membrane had been weakened and breached by the flush. Virus dies and patient at this stage would feel totally renewed and refreshed and free. Patient may experience an outbreak during the course of treatment which is expected but the appearance of the outbreak would prove patient is on track and doing well because the outbreak would be totally different from what used to be as I guarantee, no feverish feelings, no itch or tingling and no water retention in any rash that may appear. By the time we are done you can say goodbye to any form of breakouts be they stress triggered or not as you test negative. My remedy has zero side effects and works like a charm. Cost for each months treatment stands at $380. Patient has the option of running a monthly treatment thus paying monthly or paying for the entire 3 months and receiving all the remedies for the entire 3 months with directions on how to prepare them and the dose to take per time. Patient would also be required to keep in touch with me thus providing me with updates regarding progress reports so I can know if there is need to increase the dosage or leave it as it is. A diet plan would also be provided for the patient during the course of treatment. Long story short, I will work with patient for the entire 3 months of treatment up to the point of testing negative. Good morning once again. [Name]" So: 1) Not even one scientific proof. How should anyone believe your clients are "negative" if you can't prove?  2) 380 x 3 = 1140 $ for something that has no scientific proof at all AND moreover for something that up to now is IMPOSSIBLE. "This dislodges the virus from whatever nerve endings it has gone." Come on, that is impossible, as well as killing HSV from anyone's blood!  Again, you are a scam. And I feel so sad for all these desperate people who pay you a minimum of 1140$ for a treatment that doesn't work. 
    • rareangel
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