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twinsuns

Timing of Valtrex

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twinsuns

Hey everyone, just wondering how much time valtrex takes to start reducing assymptomatic shedding? Like if my girlfriend lives out of town, it doesn't make sense for me to take the meds every day, but I was wondering how long before I see her I should be starting the daily meds.

Thanks again

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justmyself

I took the episodic dosage of Valtrex for 10 days. I have not gone on suppressive medications. Some people choose to take the suppressives to lessen the chances of spreading it to a non-infected person, some take it to lessen the chances of them having an outbreak. It is a personal decision as to whether to take suppressives or not. If you are not having an outbreak and don't use protection and are not on suppressive meds, there is only a 4% chance of spreading the virus. If you use suppressive meds, use a condom and are not in an outbreak, the risk is reduced to 2%. To me, the key seems to be to not have sex with an uninfected partner during an outbreak or prodrome symptoms (itching, tingling, etc.).

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twinsuns

Thanks for your input. I did not realize that if one is not having an out break the odds of transmission are only 4%. I didn't realize it was this low. Still wondering how long one should take suppressive meds before they actually lower assymptomatic shedding.

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Was23
... Still wondering how long one should take suppressive meds before they actually lower assymptomatic shedding.

You might want to check out the two studies referenced below, which looked at shedding with acyclovir. (in particular, Fig 1 in ref 1, and fig 4 in ref 2). From my reading of them, I would GUESS(!) that you could start taking it 3 days before she arrives and be safe, and could, assuming you took the meds for a bunch of days in a row, stop at least 1, (and perhaps as many as 3 days) prior to her departing. But of course, you'd hate to have an OB occur 2 days before she arrives, so factor that into your decision on how early to start.

At least that is my analysis of the data, but don't rely on the opinion of an anonymous innertubes poster: read 'em yourself and draw your own conclusions.

In those studies they used acyclovir 400-mg twice a day. I think Valtrex is equivalent in a once-a-day dose.

1) Ann. Intern. Med. 124:8, 1996 and 2) J. Clin. Inv. 99: 1092, 1997

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