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eternalpositive

Drug pipelines

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eternalpositive

Does anyone have access to this? it would be informative to see this info but you have to pay for it. has anyone purchased it?

Life Science Analytics, Herpes Simplex Virus Infection Therapy Area Pipeline Report contains detailed information on the herpes simplex virus infection drug pipeline. This report provides insight into the pipeline status of herpes simplex virus infection drugs by company and by stage as well as a summary of the latest news and developments in this area.

http://www.researchandmarkets.com/reportinfo.asp?report_id=855822&t=t&cat_id=

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marrymak

In the pharmaceuticals sector, a drugs pipeline consists of the drugs that a company has under development or is testing. This includes completely new drugs, variants of existing drugs and new applications of existing drugs.

The pipeline starts with new drug discoveries and it is important to assess companies' ability to discover new drugs as well as drugs that are currently in the pipeline. The early stage of the pipeline needs to be refilled as drugs move up. Good R & D is crucial.

New drugs require extensive development, pre-clinical testing, three stages of clinical trials and then have to approved in each country the company wishes to sell the drug in. This means that many uncertainties lie between discovering a new drug and selling it. The uncertainties lessen as a drug moves along the pipeline .

It is not uncommon for companies to buy and sell drugs that are in various stages of development, or to enter into agreements to jointly develop or market drugs. In these circumstances one company may receive milestone payments from another for completing particular stages of development, trials and approval, as well as royalties on the drug once it is marketed.

Major pharmaceutical companies always have pipelines with many drugs in them. This may appear to spread the risk, but it is often the case that most of the value of the pipeline lies in a small number of drugs, or even in a single "blockbuster" drug

Assessing the pipeline is often the most important part of valuing a pharmaceutical company, and the most difficult. The value of a pipeline is the sum of the values of each drug in the pipeline. To assess the value of a drug in the pipeline one needs to consider:

  • the size of potential market for the drug
  • how much market share the drug will be able to gain
  • the risk that it will not be approved.

The size of the potential market may be clear. If the drug is to treat a specific disease, recognised disease for which the need for treatment is accepted it may be easy. However if the diagnosis or treatment is a matter of controversy, if existing treatments are effective or if treatment is so expensive that health services or insurers may not pay for it, then the market size is less clear.

How much market share a drug gains will depend on its cost and effectiveness compared to competitors. This includes not just the drugs already on the market, but others that are in development.

The risk of failure to gain approval is the hardest thing to assess. It requires evidence of both effectiveness and safety. Effectiveness is generally demonstrated fairly early on (but not always). Safety problems may show up at any point in the clinical trials, although the risk diminishes in the later stages.

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      I know this thread is a couple of years old, but it’s been helpful to me, and I wanted to contribute as well. Back to Berliner’s original post, I’ve tested negative on several IGGs, with the latest ones being 1 yr and now almost 2 years past exposure.  Figuring out what was going on was the worst nightmare I’ve ever been through in my life. I made the mistake of drinking heavily a week after my father died of cancer, and I had unprotected AS with an ex, who happened to be poly and had some occasional unprotected M2M encounters.   Three days later I had a red line rash along my (sorry to get explicit) crack. This was followed by a rectal burning. Tested negative for G&C and related tests.  Over the next couple of weeks I had severe swelling and discomfort in my lower right quadrant and was told to go to the ER, where (I guess as a standard practice) they did a cat scan, which revealed nothing.  Also not a bacterial infection.  However the repeated manual examinations that occurred at urgent care and the ER seemed to relieve the abdominal pressure over the next few days.  I then had diarrhea for the next several weeks after.  I developed what felt like internal hemorrhoids, which were exacerbated by the diarrhea, and a gastro doctor confirmed via digital exam that there was indeed some sort of mass that felt like possible hemorrhoids. He ordered a sigmoidoscopy, but by the time it was undertaken, whatever was there was gone. After the procedure though, I felt much better for a while, possibly due to digestive issues clearing up after the colon “cleanse.” But this was concurrent with other issues.   About 3 weeks after the encounter I developed a large rash on my left thigh. Shortly thereafter I started having light sensitivity issues, culminating in a fever-like state after being outside in the sun only for 15 minutes after work. At work around that time for a couple days I felt like I was going through life encased in a gauzy gel- similar to being on laughing gas at the dentist, but not in a good way. I didn’t know what the hell was happening to me. I developed a severe case of canker sores for about a day. Later during a sunny drive, after getting back in the car at a gas station I noticed a red blotch below my lip. I tried to shrug it off but it happened again on the trip back.  So by about a month after the encounter I was having more anxiety. I spent the night at a friend’s house and woke up with a massive, swollen red eye and swollen lips. I got eye drops for bacterial conjunctivitis but that was wishful thinking.  A couple of weeks later, my lips were covered in sores. I smothered them with abreva. By the next day, they had mostly gone away. I tried to do a swab test at urgent care (I believe it was the next day), but there was not enough there to make any sort of positive diagnosis. Since then, I’ve had what you could call repeated aborted lesions and red blotches that appear around my mouth, particularly after stress and alcohol consumption. But even having peanut butter or chocolate would set it off for a long time. Fair skin doesn’t help- there was no hiding it. 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    • Rockster
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