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Drug pipelines

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Does anyone have access to this? it would be informative to see this info but you have to pay for it. has anyone purchased it?

Life Science Analytics, Herpes Simplex Virus Infection Therapy Area Pipeline Report contains detailed information on the herpes simplex virus infection drug pipeline. This report provides insight into the pipeline status of herpes simplex virus infection drugs by company and by stage as well as a summary of the latest news and developments in this area.


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In the pharmaceuticals sector, a drugs pipeline consists of the drugs that a company has under development or is testing. This includes completely new drugs, variants of existing drugs and new applications of existing drugs.

The pipeline starts with new drug discoveries and it is important to assess companies' ability to discover new drugs as well as drugs that are currently in the pipeline. The early stage of the pipeline needs to be refilled as drugs move up. Good R & D is crucial.

New drugs require extensive development, pre-clinical testing, three stages of clinical trials and then have to approved in each country the company wishes to sell the drug in. This means that many uncertainties lie between discovering a new drug and selling it. The uncertainties lessen as a drug moves along the pipeline .

It is not uncommon for companies to buy and sell drugs that are in various stages of development, or to enter into agreements to jointly develop or market drugs. In these circumstances one company may receive milestone payments from another for completing particular stages of development, trials and approval, as well as royalties on the drug once it is marketed.

Major pharmaceutical companies always have pipelines with many drugs in them. This may appear to spread the risk, but it is often the case that most of the value of the pipeline lies in a small number of drugs, or even in a single "blockbuster" drug

Assessing the pipeline is often the most important part of valuing a pharmaceutical company, and the most difficult. The value of a pipeline is the sum of the values of each drug in the pipeline. To assess the value of a drug in the pipeline one needs to consider:

  • the size of potential market for the drug
  • how much market share the drug will be able to gain
  • the risk that it will not be approved.

The size of the potential market may be clear. If the drug is to treat a specific disease, recognised disease for which the need for treatment is accepted it may be easy. However if the diagnosis or treatment is a matter of controversy, if existing treatments are effective or if treatment is so expensive that health services or insurers may not pay for it, then the market size is less clear.

How much market share a drug gains will depend on its cost and effectiveness compared to competitors. This includes not just the drugs already on the market, but others that are in development.

The risk of failure to gain approval is the hardest thing to assess. It requires evidence of both effectiveness and safety. Effectiveness is generally demonstrated fairly early on (but not always). Safety problems may show up at any point in the clinical trials, although the risk diminishes in the later stages.


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Try a Lysine supplement for cold sores

  • The Hive is Thriving!

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    • MrKyGuy
      I hooked up with a girl yesterday and I lightly kissed her on the lips four or five times - these were not heavy deep kisses.  As she was leaving I noticed that she had a cold sore that was healing (scabbed) on the top part of her lip. My lips definitely made contact with the scab. I’ve never had a cold sore and my last std test was negative for everything . Any chance I don’t end up with HSV1 on my mouth now after this incident? I know it’s not the end of the world but everything I read says these sores are crazy contagious and primary outbreaks in adults can be brutal. Any insight is greatly appreciated 
    • dont quit!17
      From what I understand shedding studies are expensive but even getting quotes and estimates on this especially in a clinical setting would be a step in the right direction. @destroyhsv, maybe you can look up labcorp or quest diagnostics and call for an estimate or any local labs in your area. 
    • MyOhMy2018
      Hello everyone, Long story short - I had my first outbreak about a year ago, got swabbed and turned out positive to HSV-2. For the first month, I only took valaciclovir when I had an outbreak but seeing that I still had back to back outbreaks, the doctor decided to put me on suppressive therapy. This has never really helped, unfortunately. In the summer, I had no outbreaks for like one and half month but apart from that, I've been having outbreaks every other week. I saw a dermatologist about two weeks ago and he swabbed another lesion that was in my mouth, which in turn revealed positive to HSV-1, although I was on valtrex at that time. He seemed very surprised and said that not responding to valaciclovir is something extremely rare... But reading testimonies here, it doesn't seem to be as rare as people think. The last two~three weeks have been the worst for me: my outbreaks won't stop and it seems to be getting worst and worst. 2 days ago, my doctor put me on the non-generic valaciclovir  just to see if I responded better to the "real" drug but this has not helped so far.  I'm a healthy adult, I eat well, get plenty of sleep (I even take naps ) and exercise 4 to 5 days a week. I supplement daily with organic acerola vitamin C (1000mg), lysine (1 to 2g) and magnesium (500 mg to 1g) and take 1 x 500mg valtrex in the morning and evening.  I'd like to hear stories of people who managed to stop or at least reduce their recurrences and what worked for them. I really need help because that is killing my sexual life, and I'm not even 30. I've read a lot of studies on the internet about people developing resistance to ACV and the likes but none of them mentions an alternative solution for people like me. Actually, I'm not even sure I have developed resistance to ACV because the drug never really worked for me. Moreover, the very few acknowledged ACV resistant cases were in majority immunocompromised patients and as far as I know, this is not my case. I wouldn't really care about that virus if I had only one or two outbreaks a year, but having it non-stop is very hard to handle psychologically. I can't have sex, drink, eat chocolate... Even read that exercising too much could trigger outbreaks. What's left for me to do? Shave my head, go to Bhutan, live with the monks and meditate 12 hours a day?
    • vzhe
      I'd participate and pay for it if you figure out how to do a shedding study. I don't think anything other than a shedding study makes sense.
    • WilsoInAus
      HSV-2 is only required to be disclosed in some states of the US if and only if you know or could have been reasonably expected to know you have it. There are no laws surrounding HSV-1 disclosure or transmission.

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