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schmack

tenofovir gel microbicide

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schmack

Just posted on cnn today.

http://www.cnn.com/2010/HEALTH/07/19/hiv.gel.protection/index.html

The two-and-a-half-year-old CAPRISA trial followed nearly 900 HIV-negative, sexually active South African women between ages 18 and 40 to determine how safe and effective tenofovir gel was in preventing HIV infection.

Researchers found the gel overall reduced infection by 50 percent after a year and 39 percent after 30 months. In women who used the drug consistently infection was reduced 54 percent. The gel was used up to 12 hours before and within 12 hours of sexual intercourse. The study found the gel also reduced the risk of genital herpes by 51 percent.

Didn't know they were testing this for hsv. In line with my general thinking that our best chance of getting anything for hsv is by researchers stumbling on something while testing it on hiv.

I'll try to do some more research, but immediate reaction is 51%?! That's better than condoms!

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schmack

http://finance.yahoo.com/news/AIDS-breakthrough-Gel-helps-apf-1309308656.html?x=0&sec=topStories&pos=6&asset=&ccode=

Some highlights:

"In the study, women used the gel only 60 percent of the time; those who used it more often had higher rates of protection."

"The gel seemed safe -- only mild diarrhea was slightly more common among those using it. Surveys showed that the vast majority of women found it easy to use and said their partners didn't mind it."

"The biggest cost of the gel is the plastic applicator -- about 32 cents, which hopefully would be lower when mass-produced, researchers said."

Most importantly, after years of repeated failures, we may finally have proof that the microbicide concept is sound. How long til they perfect it?

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schmack

Starpharma stock up 4 percent today. Let the races begin!

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soul5821

So this is a different gel than vivagel???? let's the race begins..., Hopefully in the near future the same it will happens with herpes drugs...

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schmack
So this is a different gel than vivagel???? let's the race begins..., Hopefully in the near future the same it will happens with herpes drugs...

Yes this would appear to be competition for vivagel. Starpharma stock up another five percent today though, most likely because we finally have proof that a micobicide works! In people, that is. We already knew vivagel worked in animals.

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schmack

http://www.medpagetoday.com/MeetingCoverage/IAC/21282

HSV-2, Abdool Karin said, is "ubiquitous" and in Africa is found in about half the population. Importantly, it is usually without symptoms in women.

The researchers were interested in seeing what effect the gel -- with a 1% tenofovir concentration -- would have on HSV-2, because a sister molecule, adefovir (Hepsera) is active against the virus, Abdool Karim said.

He and his colleagues looked at blood samples taken when women entered the 30-month study and when they left. Of the 889 women in the study, he said, slightly more than half already had HSV-2 at the beginning of the study and were excluded from the analysis.

Of the 434 who were initially at risk of acquiring the virus, 208 were in the tenofovir arm and 226 were using the placebo gel, he said. After excluding some women with missing data and those whose test results at the end were equivocal, 202 women who got tenofovir and 224 on placebo were considered to have completed the HSV-2 study.

There were 29 new cases of HSV-2 among those getting tenofovir and 58 in the placebo group, Abdool Karim reported, which works out to rates of 9.9 and 20.2 per 100 woman-years, respectively. The incidence rate ratio was 0.49, with a 95% confidence interval from 0.30 to 0.78, which was significant at P=0.003.

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  • Posts

    • viralfrog
      Having HSV-2 has not bothered me at all for casual sex. I'm just avoiding sex during outbreaks, on suppressive therapy and using condoms every time with casual partners. Since my outbreaks appear on top of my penis, even during an outbreak the risk is minimal if I put a condom on as soon as I take my underwear off.  I guess it might be a slightly different case for a girl as if you have external lesions around your groin you could still infect someone even using a condom. And of course, condoms can break, which has happened to me over 10 times and caused myself to get infected in the first place.  I see it as a much more difficult now having a serious relationship, because I can't feel much with a condom on and really want stop using them. However, I don't want to put my new girlfriend to any risk - I would feel terrible if I infected her. 
    • viralfrog
      Does anyone have experience about people's reactions to Herpes in Asia? Personally I live in Thailand where I also caught the virus as a condom broke 4 years ago.  Unfortunately I infected my ex-girlfriend with HSV-2. This was just after I had caught the virus myself and we had sex before I noticed and realised what it was. In the beginning, a local doctor told me I have just hurt my foreskin with my jeans' zipper and the tests came as negative. After getting tested later it came as positive.  Anyways, my ex-gf (well educated, professional, 26 years old then) she had no idea what Herpes was in the first place. She didn't really care too much about it and didn't bother to get tested. During our 3 year relationship we kept having unprotected sex as usual and she never had any issues until at the end one day. She had a very minor outbreak once and nothing after that (lucky her, no like myself who gets terrible symptoms non-stop). I know she has a strong immune system, because she was never sick despite myself having bad colds quite often. In any case, she could not care less about this virus and didn't mind at all.

      I've seen a lot of hysteria surrounding Herpes in Europe and the US. What has been your experience in South-East Asian countries like Thailand? Do people perceive HSV-2 as a worrying disease? 
    • Burty
      The full article is behind a paywall but you could write the the authors and request a copy.
    • OFMDH
      The jury is still out as there needs to be additional experiments. Editas' results make me believe dosing was insufficient among other issues.
    • moialbalushi
      Wow interesting !! But how did they provide it to him !! I mean he is 27 years old !!
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