Jump to content
World's Largest Herpes Support Group
Sign in to follow this  
schmack

tenofovir gel microbicide

Recommended Posts

schmack

Just posted on cnn today.

http://www.cnn.com/2010/HEALTH/07/19/hiv.gel.protection/index.html

The two-and-a-half-year-old CAPRISA trial followed nearly 900 HIV-negative, sexually active South African women between ages 18 and 40 to determine how safe and effective tenofovir gel was in preventing HIV infection.

Researchers found the gel overall reduced infection by 50 percent after a year and 39 percent after 30 months. In women who used the drug consistently infection was reduced 54 percent. The gel was used up to 12 hours before and within 12 hours of sexual intercourse. The study found the gel also reduced the risk of genital herpes by 51 percent.

Didn't know they were testing this for hsv. In line with my general thinking that our best chance of getting anything for hsv is by researchers stumbling on something while testing it on hiv.

I'll try to do some more research, but immediate reaction is 51%?! That's better than condoms!

Share this post


Link to post
Share on other sites
schmack

http://finance.yahoo.com/news/AIDS-breakthrough-Gel-helps-apf-1309308656.html?x=0&sec=topStories&pos=6&asset=&ccode=

Some highlights:

"In the study, women used the gel only 60 percent of the time; those who used it more often had higher rates of protection."

"The gel seemed safe -- only mild diarrhea was slightly more common among those using it. Surveys showed that the vast majority of women found it easy to use and said their partners didn't mind it."

"The biggest cost of the gel is the plastic applicator -- about 32 cents, which hopefully would be lower when mass-produced, researchers said."

Most importantly, after years of repeated failures, we may finally have proof that the microbicide concept is sound. How long til they perfect it?

Share this post


Link to post
Share on other sites
soul5821

So this is a different gel than vivagel???? let's the race begins..., Hopefully in the near future the same it will happens with herpes drugs...

Share this post


Link to post
Share on other sites
schmack
So this is a different gel than vivagel???? let's the race begins..., Hopefully in the near future the same it will happens with herpes drugs...

Yes this would appear to be competition for vivagel. Starpharma stock up another five percent today though, most likely because we finally have proof that a micobicide works! In people, that is. We already knew vivagel worked in animals.

Share this post


Link to post
Share on other sites
schmack

http://www.medpagetoday.com/MeetingCoverage/IAC/21282

HSV-2, Abdool Karin said, is "ubiquitous" and in Africa is found in about half the population. Importantly, it is usually without symptoms in women.

The researchers were interested in seeing what effect the gel -- with a 1% tenofovir concentration -- would have on HSV-2, because a sister molecule, adefovir (Hepsera) is active against the virus, Abdool Karim said.

He and his colleagues looked at blood samples taken when women entered the 30-month study and when they left. Of the 889 women in the study, he said, slightly more than half already had HSV-2 at the beginning of the study and were excluded from the analysis.

Of the 434 who were initially at risk of acquiring the virus, 208 were in the tenofovir arm and 226 were using the placebo gel, he said. After excluding some women with missing data and those whose test results at the end were equivocal, 202 women who got tenofovir and 224 on placebo were considered to have completed the HSV-2 study.

There were 29 new cases of HSV-2 among those getting tenofovir and 58 in the placebo group, Abdool Karim reported, which works out to rates of 9.9 and 20.2 per 100 woman-years, respectively. The incidence rate ratio was 0.49, with a 95% confidence interval from 0.30 to 0.78, which was significant at P=0.003.

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Sign in to follow this  

  • The Hive is Thriving!

    • Total Topics
      69,761
    • Total Posts
      470,458
  • Posts

    • TerribleAtUserNames
      Oh, sorry, I think the catchy title I used was very misleading. And I didn't intend that. I put 'miracle cure' as air quotes because I don't actually think I've discovered a true cure. I mean, I still can get outbreaks, the virus is obviously still there. I like to at least think I'm not that arrogant or naive. 🙄 I had not definitively said anything for a couple reasons, including that I don't prefer making overly definitive statements to things I don't know.  And I was more talking with regard to what you were saying in your second paragraph in your most recent reply, whether tissue absorption had any additional effect to simple topical application. So, hopefully that's cleared up. But it is effectively a functional cure for me. In so far as I've gone from permanent outbreaks to one maybe every... 8ish months? I barely remember I have it.  And the point is that the virus has really impacted some people's lives. To the point where they take crazy--high risk--'treatments' or think about self harm. And if some other people can get the relief I've gotten from something so stupidly simple, I want them to be able to have that too. Especially given that the risk-reward ratio is--in my opinion at least--very favourable. I mean, its like literally 20-30 seconds of isopropyl alcohol a day. If it doesn't do jack for you in two weeks, move on--y'know? But I assume if it acts a particular way for me, it will likely act that way for at least someone else. And that could really change someone's life... Like it did mine.  Cheers, 
    • Cas9
      @TerribleAtUserNames OK, you need to understand the science. Alcohol does not seep into a nerve cell and kill the latent virus; That's a scientific fact. So you don't need to worry about checking. All the alcohol does is kill the virus on the skin surface. Whether it gets a little deeper in the skin layers and kills virus better than soap and water, I can't say for sure. Obviously, popping a blister and using alcohol will have a more drying effect than soap and water. The bottom line is that killing a herpes virus is easy when it's outside the nerve cell. Killing it in a nerve cell is difficult because anything that gets into the cell and kills the virus (breaking up it's dna), must not also damage the cell's dna. You need a smart bomb to do that. That's what gene editing is. It is programmed to have the ability to cut out dna segments specific to the virus without touching the cells dna. You have this image of the cell as a container and the alcohol just pours into it and kills the virus. If that was the case, it would destroy the cell's dna also. Cells are living things that have receptors on their cellular surface. Anything that gets into that cell, must have the protein that matches with one of the cell's receptors (like a key to a lock), which in turn causes the cell to let the substance enter. That's one method of how something gets in a cell. Do you honestly think that in all the decades that great scientific minds have tried to tackle this problem, that they simply missed your alcohol cure? C'mon man!!!      
    • dont quit!17
      That would be nice to have as an option. 
    • dont quit!17
      The momentum slowed down, when that forum member asked for a timeline. That is the last thing we should be asking. That's pretty frustrating. 
    • TerribleAtUserNames
      Hey everyone, thanks for responding! So you know, I updated the original post with negative effects I've experienced with alcohol as treatment, so feel free to check that out if you're curious.  Now, to what you guys were saying...    MaxTX: I actually use alcohol as my disinfectant of choice for most wounds. And sutiability seems to vary based on the type of alcohol used (says the internet). That being said, you are right apparently--but this isn't about the best wound treatment method. Its about stopping outbreaks. Regardless, I suspect the deleterious effects are fairly minor if you're trying to disinfect most wounds, but that's totally my personal opinion.  None the less, I'd suggest giving it a shot for outbreak prevention. It certainly works for me, hopefully it will for you too. And compared to taking an experimental vaccine or something like that, wouldn't this be easy and super low risk to try? Also if you google 'herpes' and 'alcohol' you can find a number of hits suggesting its use as a disinfectant for the sores.   Tired of Waiting: I'm sorry, it was a long time ago that I read her talking about it. But from what I remember, she was talking about wiping down there with alcohol, and how it helped with her outbreaks. I remember her also saying it burned like a mofo at first, but eventually became kinda second nature. I don't know what type of alcohol she used, sorry. Again, if you're concerned, maybe ask your doctor about safety? Like I said, isopropyl has worked well for me. I actually do use it before sex for that reason, back when I was having sex that is. Across 3 partners used with, no known infections--but given that I have hsv 1, and like 50-60% of the population is infected already, but only 10% present with symptoms, that could mean nothing. Unfortunately, I'm not a doctor, and certainly not one that has researched this scientifically, so I can't give you a firm answer for transmission prevention during sex. Personally, I'm confident in at least isopropyl alcohol's herpes killing abilities, even if just topically. For better or worse, real or imagined (but I suspect real), I let myself relax a lot more when using it before sex.  And then again after sex, for my own sake, hahaha, as I'm not overly keen on risking anything else. However, even this is something to consult a doctor about--I feel like there is conflicting information on whether it can be helpful post coitus, or whether it can actually increase the risk of getting an sti vs. simply washing. Imo, do some research and ask a physician to confirm or deny what you've learned.   Cas9: Soap and water never worked anywhere close to as well for me. Soap and water still meant permanent outbreak. So I suspect the alcohol is doing much more. I should clarify though, that I do actually dilligently use soap and water as well--the whole regular bathing thing 😁 I know you suggested to Tired of Waiting that it wouldn't affect outbreak frequency or the latent virus. I can't obviously check my own latent virus levels, but yes I can still get outbreaks if I stop using the alcohol. However I can, indeed, use it as a prophylactic for outbreaks, and it does prevent me from getting them the vast majority of the time. Perhaps because that kind of tissue is more absorbent or something? Or perhaps when topically applied the alcohol is significantly more potent and herpes unfriendly--which I believe really is also the case from what I've read. I know though that I can't discontinue alcohol treatment for more than 6ish days (my limit so far) without flaring up again. And with twice daily showers, that would strongly imply that soap and water is really not helping the same way.  Cheers, guys! 
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.