Jump to content

Ribavirin - results are in!


struggle83

Recommended Posts

Ok, I just finished up my last dose of 8 days of Ribavirin. The results have been fairly substantial considering the short duration and low dosage. Several of the symptoms that have plagued me for months have resolved, including many of those months of valtrex treatment. I would have to say that for me, this drug has proven EFFECTIVE.

Some things I find interesting about Ribavirin:

  • Broad range antiviral that has proven effective against HSV (possibly potentiates valtrex)
  • High toxicity
  • RNA lethal mutagenesis

I think that for the low dose and short duration I am safe from the toxic effects.

Some history - this drug was developed in the 60-70's. This was before Big Pharma got into the game. A parallel can be drawn with Prozac. That was the age of not-for-profit research, at least not like it is today.

Since those days new "designer" drug have been made like valtrex, famvir and a host of new anti-depressant (SSRI's, SNRI's etc.). But what I have found is that (with anti-depressants) when a patient proves difficult to treat with the modern medicines, doctors typically go back to Prozac (Old Faithful). No substantial money is made from this since it has long gone generic. You will notice that psychiatrists typically provide a new patient with samples that they got from Big Pharma to try out. They want to push those even though they may not be the most effective.

I wonder if the same is true for Ribavirin. It was developed before Big Pharma could get it's hands on it. It is long been generic. I don't see much modern research for it as a treatment for HSV. It could be that doctors think it is too toxic, which it might be for the casual HSV sufferer who responds to valtrex. Enough about that.

RNA lethal mutagenesis really interests me. It is a novel mechanism of action, much different from the x-cyclovirs. It must affect the HSV RNA process or else it wouldn't be effective at all. I think that RNA is involved in the DNA replication. If this is true I wonder, and this is just my hypothesis, if damaging HSV RNA has a permanent effect? It would be throwing the proverbial wrench in the HSV machine. I don't know if this is true but if it is it would provide a more permanent solution than taking valtrex the rest of your life (which would make Pharma happy). Since HSV is a DNA virus and not an RNA virus, lethal mutation of RNA could be permanent. This would have to be answered by an expert and even then I would take the answer with a grain of salt because I don't think this has been specifically researched.

I know this might come off as a conspiracy theory that I typically disregard but I can't help but think where there is smoke there is fire. Hopefully it's smoke from the crippled HSV factory!

Link to comment
Share on other sites

Hi

When you say that it has worked for you, what exactly do you mean: it has stopped recurrences (wich time frame), have you tested your antibodies,...I mean, can you report in facts the improvements of this medicine in your herpes problem?

I´m not trying to be rude, just interested in it if it really works....

Also, did you need a presciption to buy it, or did you just buy it?

Thanks

Link to comment
Share on other sites

I cannot report in facts any more than anyone else, inlcuding clinical trials, which are all subjective, in truth. You cannot test antibody levels with this virus - there is no such thing as HSV viral load, at least not without biopsy. I can only tell you that after 6 months of symptoms I have had some relief.

I will definitely update on recurrences.

This is a prescription medicine. Taking it is a personal choice. If you do not respond to valtrex or want to try something new it is an option.

PM me for more details if you like.

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.



  • Donate

    If Honeycomb has helped you, please help us by making a donation so we can provide you with even better features and services.

  • The Hive is Thriving!

    • Total Topics
      72.1k
    • Total Posts
      486.4k
  • Posts

    • WilsoInAus
      Hi there @ScubaSteeve and welcome to the website. If you have had genital HSV for 10 years there is a chance the testing did not distinguish type. The answers to the following questions will help a bit: - where are your outbreaks specifically and what frequency? - have you had any IgG antibody testing for HSV?
    • CHT
      Hi LLS.... I'm very sorry you are having so much discomfort from this outbreak.... the first outbreaks are always the most troublesome but  they will get less aggressive as time passes.  I personally find that valacyclovir is much more effective than just acyclovir so you may want to ask your doctor about switching and seeing if that helps.  Ask your doctor on Saturday if you really need to take a higher dose.... and as WilsoInAus suggested, I would ask for a 1,000 mg tablets with at least a 90 day supply to start.  As for pain, you may want to ask your doctor for a Rx of Zovirax ointment.... it contains acyclovir and the ointment form calms the sores down and reduces friction.... it should lessen the pain down there. As for diet, many people, myself included, learn what foods often act as triggers for outbreaks.  I can tell you from experience that the following are big outbreak triggers for me:   1. Too much caffeine (I've basically stopped coffee and have learned to enjoy a variety of decaf teas) 2. Any kind of nuts - including corn and even popcorn 3. Chocolate 4. Too much alcohol - particularly red wines  5. If possible, avoid any kind of steroids/immunosuppressants like prednisone in high doses.... anything that suppresses your immune system will give the virus free rein to run amuck - I learned this the hard way! 6, Stress.... although easier said than done, it will help with your overall health.  Studies show that stress is a common HSV outbreak trigger.... try to find a way to lower your stress levels. 7. lack of sleep.... personally, if I get less than 6  hours of sleep this often leads to an outbreak within a day or two.... work at getting a good 7-8 hours of solid sleep each night (I often use melatonin to help here). Some people find certain vitamins that boost the immune system, like zinc, help with overall healing and can lessen the severity of outbreaks and possibly prevent some outbreaks.  I personally take a number of antiviral/anti-inflammatory/anti-oxidant herbs/vitamins not so much for my HSV2 but for overall health (I don't have the healthiest of diets so, I feel I need to supplement to offset my lousy diet).  A google search of supplements that help with herpes will provide you with a long list of vitamins/herbs that may be of benefit but, try not to get carried away - many/most won't make much, if any, difference.... but, you can always experiment. As WilsoInAus also mentioned, a healthy diet is likely your best option. I should also mention that while some find vitamin C to be helpful, I found it to have the opposite effect.... the more I took the more it seemed to provoke outbreaks.   Things are always the toughest after initial infection.... it's going to get better, trust me.  Stick with the antiviral meds daily, try not to obsess on the fact you've contracted this virus, and try to avoid some of those triggers relating to outbreaks.  With time the number of outbreaks starts to decline and when you do have an outbreak, they will become less virulent. As WilsoInAus mentioned, a lot of your achiness, pain and overall flu-like symptoms are related to the fact your immune system is adjusting to this virus.... these lousy symptoms are just your immune system in action working to do its best to fight this virus... with time these symptoms will also lessen and disappear.   I hope this helps in some way.... please let us know if you have more questions.... and remember, go easy on yourself right now.... turn to those things in your life that calm you and also distract you from obsessing over the virus situation.  You are going to be just fine.... just give yourself some time to get past this initial unpleasant phase.... it will get better, I promise.    
    • Justme88
      Thanks.
    • ScubaSteeve
      I was diagnosed with HPV2 ten years ago, which I contracted from an ex-girlfriend who was unaware she had it. Since then, I've lived a reserved life, not really opening up to others. There was only one person I felt interested in enough to share this with, but it didn't work out. There have been a few instances where I've let my guard down, had a night out, and ended up sleeping with someone. I know I should feel guilty about not discussing it beforehand, but I found it challenging because they know my family, and it felt overwhelming at the time, and I had alot of pent up desires from not ever being with someone for a long time.  After finally opening up to someone and realizing it wasn't the end of the world, I now understand that finding the right partner might be a matter of numbers. I desire to have more intimate relationships but need to find better ways to approach this topic and ensure I never spread it.  Thank you all for providing a space where I can be myself.
    • i82much2young
      My swab results won’t be ready for another 5 days. Is there any harm is continuing the Valacyclovir? I was prescribed 1gm tablets for 10 days.
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.