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otherwiseperky

Vical

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JBnATL

This looks promising, thanks for posting.

Come to the Chat Room, there you will find many nice fellow Herpsters who can offer you their support.

Good luck!

JB

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helpiamconfused2
Finally they have posted their HSV vaccine on their website. Looks like they're in preclinicals and have also received a grant.

http://vical.com/products/infectious-disease-vaccines/HSV-2-vaccine/default.aspx

It looks like the grant they are referring to is the $2M they were awarded in 2008... It appears there has not been a lot of movement on this one since 2008. I believe they too are looking for partnering like Antigenics is...

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otherwiseperky

Yes, as well is AiCuris. They are looking for partnering/licensing too, whether or not anyone wants to acknowledge that. None of these are going to get off the ground until a major pharmaceutical company picks them up.

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helpiamconfused2
Yes, as well is AiCuris. They are looking for partnering/licensing too, whether or not anyone wants to acknowledge that. None of these are going to get off the ground until a major pharmaceutical company picks them up.

Agreed... but AICURIS has completed phase II and unfortunately Vical (which may be the better treatment, since it may be a 1 time deal) hasn't even made it to Phase I.

We have prominently mentioned Vical and Antigenics (completed Phase I) in newest petition to Congress... asking Congress to provide them with funding to get it over the hurdle...

Let's keep the pressure on our governments to help these companies... If they can find a great treatment/cure, it will bring badly needed jobs to the US.

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      Another company looking to create a vaccine.  http://www.bluewillow.com/bluewillow-biologics-awarded-patent-for-intranasal-genital-herpes-vaccine/ BlueWillow’s intranasal NanoVax platform elicits both mucosal and systemic immunity through its novel oil-in-water nanoemulsion (NE) adjuvant, offering a unique advantage to combat sexually transmitted infections (STIs) including genital herpes. The mucosal immunity elicited by intranasal NE vaccines provides critical protection against infections at the port of entry by which a pathogen enters the body. The intranasal NanoVax HSV vaccine has demonstrated safety and efficacy in both prophylactic and therapeutic animal models for genital herpes. In a prophylactic guinea pig study, the intranasal vaccine prevented genital herpes infection in 92 percent of animals vaccinated. Therapeutic study animals previously infected with genital herpes who received the BlueWillow vaccine reduced recurrent lesions and viral shedding by more than 50 percent compared to animals who received no treatment.
    • JHenry
      Cas, This is sooooooo exciting I may need a diaper!  How bout you?  😊
    • JHenry
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    • LightafterDarkness
      Discussion thread on this news here:  
    • LightafterDarkness
      This is pretty impressive for a number of reasons: Average funding for a series A in biotech is around ~$50M but the median is around ~$30M as of 2018 The takeaway then is the XVax is at the higher end of the spectrum suggesting (1) High investor interest, (2) XVax is thinking big A robust set of investors- good to see that there are multiple names here rather than 1-2. Again, suggests robust interest from investors Note that the anchor investor (i.e., the biggest) is Adjuvent who are backed by Bill and Melinda Gates Foundation, good to see that HSV continues to be of interest to them (my theory: due to the link with HIV and Alzheimer now)   Overall everyone should be cheering this news given the impressive results seen with animal models. Still remember this is going to be a multi year process- I would hope to see a phase I in 2020
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