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Margaux

Research on Seroconversion Times

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Margaux

I see a seminal article (Ashley-Morrow, Krantz, Wald, 2003) referenced very often in many threads concerning the time it takes to seroconvert. The test most frequently ordered by doctors is the Herpeselect, which takes 25 days on average til seroconversion is detected. It must be noted though, that this study does NOT use the reported exposure date as the date by which days are begun "counting" toward seroconversion. The study uses the date of the onset of symptoms. As we know, a primary outbreak, if it's going to happen on first exposure as opposed to lying dormant before ob'ing, happens 2-20 days after the exposure. If a person does not have symptoms until almost 3 weeks after an exposure, those three weeks are not factored into the 20 something days expected for seroconversion. I just figured I'd bring it up as I see a lot of people counting off weeks and wondering why they have not yet seroconverted.

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Margaux

The more I think about it, the more I realize what a limitation this is to their study. Knowing the time of seroconversion from the date of exposure might explain the vast spectrum of seroconversion days.

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death2herpes

besides the ambiguity of date of exposure, there is another point which i raise in this thread http://www.herpes-coldsores.com/messageforum/showthread.php?25112. some of the subjects characterized as "nonserocoverters" by date X were actually no longer followed up on so they distort the seroconversion percentages quoted. the times are actually shorter (or %ages higher, if you will).

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Margaux

Yes! I agree! The research is considered seminal because the literature in the field is so limited, however the study itself needs to be considered more in terms of its limitations than its findings. I am going to go read your thread now...

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