I prepared this draft message to the admin at the "+Support Groups" HSV community. Pls let me know what you think if you have any comments or suggestions before I send it.
Thank you for your message.
Perhaps I could run this by you here to get your view first.
In a nut shell, we are part of an HSV community which is helping to support HSV cure research. I know "cure" is a bit of a dirty word in the HSV community, but please kindly hear me out and, if you don't mind, please check out some of the information I share.
The Fred Hutch Cancer Research Center has been making some serious progress towards an HSV cure, even though commercialization is still tentative and some years away. They are using a technique called gene editing, and with it, they have been able to target the latent form of HSV and destroy it by disrupting its DNA. They've been able to remove over 50-90% of latent HSV when tested in mice, in effect partially curing mice from HSV.
A lot of people are excited about this research. It is partially funded by the National Institute of Health (NIH), but it is also being supported through private donations from our community. Our donations have enabled their team to progress to testing in guinea pigs before the funding for that was available from the NIH.
I'd like to ask you and the powers that be here, whether it might be ok to post about their research and to also post the link to the donation drive. Our own admins at Honeycomb.click, have let us post about it and even pinned our main post on this, which has helped us to get many people to contribute to supporting this. Over 200 members have donated and this has raised $38,000 for this research this year.
These funds are being put to good use, as explained in the last video presentation from FHC, where Dr. Jerome who heads up this research has noted that these funds have enabled them to proceed to guinea pig testing.
I'd like to share some info links with you.
First is a 2016 peer reviewed scientific research paper where they showed they could edit and deactivate 2-4% of latent HSV in mice. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026126/
Next is an article from Mens Health Magazine about the progress of this research from earlier this year, noting that removal of latent HSV has reached up to 90% in mice.
That article obviously isn't a scientific paper, but it does help to explain what they are doing in layman's terms.
Here is The latest from a series of video presentations from the Fred Hutch team. A little past the 46 minute mark Dr. Jerome gives an acknowledgment to the funds that we have raised and explains how the funding is being put to use.
Finally, a link to the NIH website which shows the grant that this research has received from the NIH last year (this grant will be active through 2023).
(Note there are 4 pages there, and the grant for Keith Jerome is on one of the pages only ("Endonuclease-mediated disruption of latent HSV as curative therapy - $450,000 in 2018).
Finally, the link to the FHC donations page for supporting this HSV cure research is here:
After looking at these infos, please kindly consider whether we would be allowed to post about the research and about the donation drive. We think it is important to get everyone on board, even if it's just a small donation of $10 to $15. This is now winding through animal studies with the aim of being tested in human clinical trials. This is a legitimate effort and we think it's an effort that is worth supporting by our community of HSV positives and related stakeholders.
I know you have posted a disclaimer about not posting about "cures", but we presume that to mean fake or scam cures ("the great Dr. Okoloko's medicinal herbal tincture etc."). This is real and legitimate research and it's exciting.
Please kindly consider if you would allow us to share this with your community. If so, we'd be very happy to share with you first the draft post and take any comments or feedback from you before posting it.
Thank you for your consideration.
400mg Pritelivir has been shown to be worse than a smaller dose daily (and that is what pharmacodynamics would predict as well). You'd expect the same with Amenamevir, though i'm not entirely sure about its half-life right now. TL;DR A weekly dose is for convenience only, i'd always prefer a more effective daily or bi-weekly dose.