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wwdamron

What ever happened to Alnylam Pharmaceuticals ??

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wwdamron

THIS IS OLD NEWS BUT I THOUGHT I MIGHT BRING IT UP AGAIN AND FOR THOSE OF YOU WHO DO NOT KNOW ABOUT IT, BUT WHAT EVER HAPPENED ABOUT THIS RESEARCH ANYONE KNOW?? :

WASHINGTON (Reuters) – Researchers say they have developed a cream that might prevent herpes infection for as long as a week — a potentially big step in protecting women from the sexually transmitted infection.

The cream uses a new kind of therapy called RNA interference to turn off genes that the virus uses to invade cells, the researchers reported on Wednesday.

The cream, being developed by Massachusetts-based Alnylam Pharmaceuticals Inc, protected mice from herpes simplex 2, the virus that causes genital herpes, Deborah Palliser of Harvard Medical School in Boston and Albert Einstein College of Medicine in new York and colleagues reported.

"A vaginal microbicide able to protect against HSV-2 transmission could contribute significantly to controlling sexually transmitted diseases," Palliser’s team wrote in the journal Cell Host & Microbe.

The World Health Organization estimates that 536 million people worldwide are infected with genital herpes, a painful and incurable virus which is highly infectious and can kill newborns.

Herpes viruses head straight to nerve cells, where they stay latent for the life of an animal or person, often causing periodic outbreaks.

Related viruses are herpes simplex 1, which causes cold sores, and varicella, which causes chicken pox and returns in middle or old age as herpes zoster to cause shingles.

Acyclovir and related drugs can suppress symptoms and are available as both creams or pills but have not been shown to prevent infection.

An estimated one in five Americans have genital herpes, according to the U.S. Centers for Disease Control and Prevention, while 100 million have HSV-1.

As a new route to making better drugs, several companies have locked onto technology using small, interfering RNAs or siRNAs. These are molecules that can silence microRNAs — tiny strands of RNA, or ribonucleic acid, that help turn genes into proteins.

The Alnylam drug targets a gene called nectin-1. Mice genetically engineered to lack this gene are less likely to be infected with HSV-2.

But the cream "silencing" nectin-1 took a day or so to become effective. Attacking a second gene called UL29, found in the virus itself, provided immediate protection, they wrote.

Using both provided about a week of protection, they said. they used a type of cholesterol to help carry the siRNAs and the resulting cream did not irritate the vaginas of the mice, they said.

"Topically applied siRNAs might be useful to treat and prevent reactivation and sexual transmission of clinically latent HSV-2 infection," they wrote.

More work is needed, they stressed, but the approach might work for other sexually transmitted infections — notably the AIDS virus.

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    • Ashleerae
      Yeah whoops, I didn't see you wrote HSV-1 until later haha. I definitely see your point. 
      Just some random thoughts on the subject that I've been thinking about similar to your situation, even if they are a little different. I've been in a workplace where a girl was the herpes girl so I totally get that. Not the brand you want. Yeah it is so common. Somebody else in the room probably has it, like you said. It feels like its so unnatural and isolated when diagnosed because nobody talks about it, but its so freaking common. Maybe people are more open about HSV1, but maybe not.  Who knows if the rest of the world will catch up. It's nice to not care what the rest of the world has to say sometimes. That would be tough at 18-22 having everyone you know find out. I assume my own hometown will find out one day from someone who knows; that was one of my other biggest fears about this too, but it's fading. I guess I better start working on my comeback game so it's in the holster when I need it Have a good night, good thread Hairpees.  
    • WilsoInAus
      Hey @Runride and welcome to the website, I hope there is some thoughts to assist in your thinking. Wow, where do live? Sounds a bit like 'Deliverance' country or something out of a David Lynch movie. I'm very sorry about that. I have three options for your consideration. They are not in order of any particular preference. 1. Ignore it. Go about your life as per normal. You are the actor on your own stage and the other players will do what they do. Do as you wish to do with your life and other people will buy into that, or they're not welcome on your journey. Herpes plays the role it always has for you. You inform partners in advance of sex. 2. Take a stand to be open about your status. Requires a bit more bravery to put yourself out there for little short term reward certainly. "Yes I have herpes like most of us do orally or genitally. What do you feel the issues surrounding this are? What ought to be different in our lives and the way we live them as a result?" 3. Move to a new environment to give yourself a better chance of living life under option 1 or even option 2 above.
    • Broken Butterfly
      For sure, why bother if it’s pointless and costly but I get what you mean.  
    • Broken Butterfly
      I said I considered it but not that I was going to sue- I have no idea what my options are here.  
    • Hairpees
      I’m definitely not saying you need to file a lawsuit, you’ll read on here most people don’t have success. I’ve mentioned it because hes not responding to you so maybe that will wake him up.
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