Sign in to follow this  
Followers 0
CurePlease

Progress in HIV Research = Progress in Herpes Research

8 posts in this topic

Article explaining considerable progress currently being made in HIV research. I personally see progress like this encouraging for herpes cures. A successful solution to HIV could be manipulated and targeted to a weakness in herpes. Don't believe those that say HIV research is irrelevant to herpes. Because its not.

http://news.yahoo.com/s/afp/20110529/hl_afp/healthaidsanniversaryus_20110529201022

Thirty years after the AIDS epidemic surfaced, hope of conquering the deadly epidemic has never been greater, according to a longtime US leader in the AIDS fight, Anthony Fauci.

This hope has been spurred by recent advances toward a vaccine and new breakthoughs in treatment and prevention, said Fauci who has headed the National Institute for Allergy and Infectious Diseases since 1984.

"Over the last one and half years we have had several important advances which when you put them together and combine them are now pointing very strongly to the fact that we can essentially be able to ultimately control and obviously ultimately end the AIDS pandemic," he told AFP.

Previous discoveries include how male circumcision can reduce by almost 65 percent the risk of transmitting the human immunodeficiency virus, the effectiveness of vaginal microbicides and drug treatments that can prevent an infected pregnant mother from passing the disease to her child.

More recently, two clinical trials have shown just how effective antiretroviral drugs can be in preventing the spread of the incurable disease.

A study that ran from 2007-2009 and was published late last year showed that a combination of these drugs taken orally by uninfected gay men lowered their risk by 44 percent of becoming infected.

That rate rose above 70 percent when the pills were taken regularly, said Fauci who added he has "been in it now literally every day of my life for the last 30 years."

A clinical trial released this month involving mainly heterosexual couples in which one was infected and one was not showed a near elimination of the risk of transmission when the infected partner began an early regimen of antiretrovirals.

This trial is "extremely important because it proves the concept that when you seek out and treat them early rather than wait for their disease to advance, you have not only the well known beneficial effect of being good for the individual patient, but you have a very powerful secondary effect of preventing the transmission from the infected partner to their healthy sexual partner," said Fauci.

The NIAID and its researchers have been at the forefront of the fight against AIDS since the epidemic first surfaced in June 1981.

With regard to the hunt for a reliable vaccine, researchers have found some hope after 20 years of failure in a 2009 clinical trial carried out in Thailand.

"The vaccine trial in Thailand was only 31% effective, however that is at least a proof of concept that we can do better."

In 2010, teams of researchers identified two antibodies in a single individual which when combined in the lab blocked 90 percent of HIV strains known in the world.

Now that research is honing in on what specific part of the virus should be isolated for a vaccine.

"So if we are going to have a vaccine this year or next year or the year after, we don't know, but we are certainly making considerable progress."

In the meantime, a more comprehensive use of existing methods for prevention must be applied in the developing world in order to put the brakes on the epidemic, Fauci said.

"In the low and middle income countries, we only have about 30 to 40 percent of the people who really need therapy getting access to therapy," he said.

"The only way we can address this -- and this is the focus of what is going on over the past couple of years -- is prevention of HIV infection."

There are 2.7 million new infections each year, he added.

This gap will be difficult to bridge, warned Fauci, especially since the global economic turndown has slashed research budgets as a time when scientists need 10 to 15 bilion dollars more per year than the total 11 billion currently available for research.

"Unfortunately there is a very difficult constraint on resources throughout the world," he said.

Share this post


Link to post
Share on other sites

I couldn't agree more. Although, I have been wondering if HSV is even more difficult to cure. A vaccine for HIV could also be very beneficial to people with GH. Even if it does nothing for ob's and shedding. If it were to bring the odds of contracting HIV back down, or eliminate it, that's enough for me. But then again, I would think such a vaccine would give us a nice immune boost.

Share this post


Link to post
Share on other sites

Yeah, I saw this article about it and was glad to see that The International AIDS Society will this month formally add the aim of finding a cure to its HIV strategy of prevention, treatment and care. The cost of treating the disease is too much now and there is hope of curing it for the first time in a long time. I found it quite interesting that a gene mutation is responsible for the 1% of caucasions who are immuned to HIV. Now I am wondering if it's the same thing with people who are immuned to HSV. I haven't found any research showing that, but only research showing that there are people who are immuned. If scientist are able to use gene therapy to cure HIV, the same technique could possibly be used to cure HSV. But, that would be many years away.

http://www.newsdaily.com/stories/tre75030i-us-aids/

Share this post


Link to post
Share on other sites

Here is another point in the article from Science Daily that I really like:

Now scientists working on mimicking the effect of the Berlin patient's transplant have had some success. One experimental technique uses gene therapy to take out certain cells, make them resistant to HIV and then put them back into patients in the hope they will survive and spread.

At an HIV conference in Boston earlier this year, American researchers presented data on six patients who had large numbers of white blood cells known as CD4 cells removed, manipulated to knock out the existing CCR5 gene, and then replaced.

"It works like scissors and cuts a piece of genetic information out of the DNA, and then closes the gap," says Huetter. "Then every cell arising from this mother cell has this same mutation."

Early results showed the mutated cells managed to survive inside the bodies of the patients at low levels, remaining present for more than three months in five. "This was a proof of concept," says Lewin. Another potential avenue is a small group of patients known as "elite controllers", who despite being infected with HIV are able to keep it under control simply with their own immune systems. Researchers hope these patients could one day be the clue to developing a successful HIV/AIDS vaccine or functional cure.

Scientists are also exploring ways to "wake up" HIV cells and kill them. As discovered in the late 1990s, HIV has a way of getting deep into the immune system itself -- into what are known as resting memory T-cells -- and going to sleep there. Hidden away, it effectively avoids drugs and the body's own immune response.

"Once it goes to sleep in a cell it can stay there forever, which is really the main reason why we can't cure HIV with current drugs," says Lewin. Her team in Melbourne and another group in the United States are about to start the first human trials using a drug called SAHA or vorinostat, made by Merck and currently used in cancer treatment, which has shown promise in being able to wake up dormant HIV.

Hmmm, cutting out the CCR5 gene and replacing it with the gene that causes immunity. That's Meganucleases. Cellectis has proven that they already have an enzyme that can do this for HSV but instead of replacing a gene, it would cut out the HSV genes so that it cannot replicate. So, if they are able to safely cure people with HIV in this way, they will also be able to cure HSV with the same technique. Looks like this promising strategy just might get moved along a little faster than originally anticipated. Keeping my fingers crossed.

Share this post


Link to post
Share on other sites

Towards the end of this video, Kate explains that only 3% of the funding for HIV from the NIH is for cure research. It's nice to see that it is increasing. But then again, I wonder if were having the same issue with HSV. Yet, if they do find the cure for HIV, that will free up a lot of funds and even boost the hope that a cure for HSV is possible. Remember, this video was posted in Nov of 2010. But recently a lot more money was granted for HIV cure research.

Share this post


Link to post
Share on other sites

THIS IS AN INTERESTING REPORT THAT TALKS ABOUT TRYING TO GET CONGRESS TO SPEED UP THE PROGRESS IN AIDS RESEARCH, IT ALSO RELATES TO HIGH PREVALENCE OF AIDS/HIV IN HOMOSEXUAL MEN AS WELL AS THE HIGHER RISK IN HOMOSEXUAL MEN CONTRACTING HERPES VIRUS TYPE 8(WHICH I DON;T HEAR MUCH ABOUT), ITS AN INTERESTING READ TO SAY THE LEAST, IT SHEDS SOME LIGHT ON WHERE MOST OF THE NIH MONEY IS GOING TO:

http://www.wnd.com/index.php?fa=PAGE.view&pageId=300089

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
Sign in to follow this  
Followers 0

  • Latest Buzz

    • crisper
      Agreed! So, how do we go from anonymity to working as a group? Maybe we can contact those we are friends with outside of the hive. Or, divide those interested by location. Or create another website. 
    • Prettypony
      I agree with both replies. I too had a mini break down, and cried all day for days. But I started to research like crazy and it really did help me come to terms with my diagnosis. Not only that but it made me feel like I had some control over it. You will get there.  Give yourself time and keep coming back to this site, it is full of great advice and support. I'm sorry you are going through this.
    • wb1242
      @JBnATL, thanks for the clarification. That's great to know. I'll almost certainly reach out to her. @Sanguine108, I have been tracking my food intake carefully for a couple of months in MyFitnessPal.  Though my nutrition isn't optimized for my current goals, I don't think there are any smoking guns in there wrt to this.. @Free73, thank you!  Great information. I think you've hit on several major points.  The hydrocortisone, in combination with the major change and 'shock' to the system, as well as general 'stress', has compromised my immune system, or at least pissed-off the HSV..  I guess it's not uncommon to see an increase in outbreaks during periods of stress and change to the body such as these.. My exercise routine is evolving as I'm still a beginner. I started in July and have been averaging ~4 workouts a week, ~100x10 sets,reps/wk.. I've been hampered lately by a strained pec minor a week or so ago which has impacted most of my upper-body work. Also, my body probably sees the additional energy demand as even more stressful due to my adrenal/RT3 issues and reduced caloric intake.  I set my levels in MFP and Garmin Connect about as low as they would let me and I'm still almost always way under.. Since you've been working out all along, what do you think has caused you increased outbreaks? 
    • Maybe1day
      Well someone's gotta get this train rolling... we can talk all we want but if the money isn't collected then nothing gets done. As it stands, no one is even working on what we need specifically. Everyone is trying to cure eye diseases, which are important, but I think a more pertinent concern is genital hsv. So, unless we get moving with this, we're gonna be stuck with it for life. Even the groups that ARE working on it, have other priorities and you can see it on their pipelines.
    • LillianPanos
      Where can you buy it?  
    • Beachguy
      We all go through storms in life. Some more difficult than others, I have been through quite a few them including H.  During these storms don't focus on the darkness but focus on the light guiding our path. While painful I believe we come out better at the end. And yes I am overwhelmed by the power of the light. not the darkness.    
    • Blahdittilyblah
      I think an initial breakdown is normal to an extent I think most of us go through a mini version. I know I did, but I'm a curious person by nature I like to investigate and research things that I know little about. I became slightly obsessed with HSV 2 and spent hours a day on my phone researching then clearing my browser history for added security lol. But I quickly learned how common it is and what it really is and that helped me accept it and begin to move forward. I suggest you do as much research as possible on this virus to ease your mind and help you better understand it. 
    • Free73
      The IGG number of 6.6 itself is meaningless in terms of trying to decipher if an infection is recent or old. It just means that you have HSV antibodies, which suggests that you contracted the virus at least 12 weeks ago or longer. It generally takes 12 weeks or longer to develop IGG antibodies after initial infection. If you had a positive IGM and a positive IGG, that would indicate a recent infection, ie less than 12 weeks ago. However, IGM tests are not considered a reliable measure these days.  
    • Free73
      it depends on your body, everyone is different. If I get an outbreak, two tablets on one day is enough to give it a zap and it starts retreating. Other people need to take for a few days. Generally speaking, for episodal, 3 days should be long enough, but again it depends on how well your body takes to the Valtrex. Luckily mine responds very rapidly to valtrex
    • Delphinium
      Bf and I are seroconcordant so not worried about spread/suppressive therapy for his protection.....was just curious for outbreak management how others take their antivirals. I don't want another outbreak as bad as the first one.
  • Featured