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fh12

anti-herpes effect of polyether antibiotic cp-44161 in vivo

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fh12

Shown inhibitory effect on HSV 2 dna in the dorsal root ganglia. Any scientists out there that can explain this? What is a polyether antibiotic?

pubmed.gov published 2/2009

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accelerate the response

http://www.ncbi.nlm.nih.gov/pubmed/19198635 is the pubmed link. They seem to be a kind of lipid antibiotic that can cross cell membranes.

Inject into the dorsal ganglia for HSV infections "below the waist" and assess results. Use animal model to test first. Assess reduction in ganglionic infection versus control group following challenge in the guinea pig model. If found to work, move swiftly to human trial.

Always nice to dream this might actually happen, in reality however...

The researchers work for the Japanese Pharma group Astellas Pharma:

http://en.wikipedia.org/wiki/Astellas_Pharma

Come on Guys, DO THE NEXT PHASE OF RESEARCH!

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lovelyoptimistic

I wish it wasn't so costly for researcher to further test findings etc. It has shown great promise but they wont continue to carry out testing. It's been 3 years! Something has to change...although i know it wont. Is this an already approved medicine with little to no side effects? If so...can they just get a large pool of hsv positive people and test the findings?!? I wish this is how it could happen. If there is no immeduate danger to the patients, i think they should be able to go from proof if concept in animal trials for effectiveness, then test a large pool of human subjects in a phase 3/4 for additional usages for the medication. Or is this how it already works?

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lovelyoptimistic

I also know it is prob considered unethical for pharma to take volunteers w/o pay. But i know that trial coast could be reduced if they did not have to reimburse people for trials. I honestly would volunteer in a heart beat if an existing med had promise of treating hsv. Existing meds to safety profiles have already been evaluated so i am certain a huge number of people would willingly volunteer if it meant some type of physical and mental relief.

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lovelyoptimistic

But if you look at their q2 financial results found in this search http://www.astellas.com/en/search/search.php?q=Herpes&cs=utf-8&x=32&y=14 it says that asp2151 their zoster and hsv drug candidate trials were suspended due to issues with safety profile. Idk if this is the same compound or nor. It then also say it was looking to reformulate it. So i:m going to look a little bit more to see if they've tried to start trials again.

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Dummy
But if you look at their q2 financial results found in this search http://www.astellas.com/en/search/search.php?q=Herpes&cs=utf-8&x=32&y=14 it says that asp2151 their zoster and hsv drug candidate trials were suspended due to issues with safety profile. Idk if this is the same compound or nor. It then also say it was looking to reformulate it. So i:m going to look a little bit more to see if they've tried to start trials again.

I think it's best to learn to live with this... So many failures at attempts to prevent transmission or outbreaks... I lose faith because the docs and scientists seem to give up...Just get used to this altered life.. We are the chosen ones I guess .... If your 20 and under you may see a cure... When someone at the highest level is affected and they figure its worth the fight.. Who knows... Shit sucks man

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osten

That's a very helpful contribution, Dummy. We need to hear random predictions and how about hopeless it is in every thread where we are looking for detailed information about specific treatments.

Anyway, here is the abstract of a recent trial for ASP2151.

http://www.ncbi.nlm.nih.gov/pubmed/22351940?dopt=Abstract

It looks like at certain doses it's somewhat more efficacious at healing lesions than valacyclovir. Nothing to write home about, but it has potential. It also says there appear to be no safety issues.

I'm still not sure if it's the same thing as CP-44161. Perhaps somebody who has contact with Anna Wald could get confirmation?

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Dummy
That's a very helpful contribution, Dummy. We need to hear random predictions and how about hopeless it is in every thread where we are looking for detailed information about specific treatments.

Anyway, here is the abstract of a recent trial for ASP2151.

http://www.ncbi.nlm.nih.gov/pubmed/22351940?dopt=Abstract

It looks like at certain doses it's somewhat more efficacious at healing lesions than valacyclovir. Nothing to write home about, but it has potential. It also says there appear to be no safety issues.

I'm still not sure if it's the same thing as CP-44161. Perhaps somebody who has contact with Anna Wald could get confirmation?

anddddd this hopeful tidbit did what??? other than give false hope like the rest of this cure section... ill take my biz to the rant section... just get tired of all this cure crap and it falls off.. cuz no one that can do something bout it gives a damn or it takes decades ... just to say the crap dont work.. lets just be happy with this crap

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