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2ifbysea

IgG negative, IgM positive?

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2ifbysea

Need some advice on test results...

My husband had a one night stand. 15 weeks post exposure I sent him to his doc for STD testing including HSV IgG. My husband has never had any symptoms of oral or genital herpes. His test results came back as....

HSV IGG type 1 positive at 2.0

HSV IGG type 2 negative at <0.2

For some reason the test also included an HSV IGM which was read as...

HSV IGM type 1 weak positive

type 2 positive

This is exactly what the test said. I am a nurse pracitioner and thought I had a fair understanding of HSV. I did not think IgM could differentiate between type 1 and 2. Since he had no symptoms, I'm not sure why this was drawn but now I don't know what to do with the results. This was done about 2 weeks ago and my husband still has not had any symptoms. The doc wanted him to start anti-virals (he thinks it is a false positive but wanted him to do this to prevent passing it to me since my herpes tests were negative) and have him retest in 6 weeks. I told my husband not to start the anti-virals yet because I don't want to muddy the waters further when the test is redrawn.

Does this sound like a false positive? Should he start the antivirals or not? Would love to hear thoughts from anyone. Thanks!

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RealisticGal
Need some advice on test results...

My husband had a one night stand. 15 weeks post exposure I sent him to his doc for STD testing including HSV IgG. My husband has never had any symptoms of oral or genital herpes. His test results came back as....

HSV IGG type 1 positive at 2.0

HSV IGG type 2 negative at <0.2

For some reason the test also included an HSV IGM which was read as...

HSV IGM type 1 weak positive

type 2 positive

This is exactly what the test said. I am a nurse pracitioner and thought I had a fair understanding of HSV. I did not think IgM could differentiate between type 1 and 2. Since he had no symptoms, I'm not sure why this was drawn but now I don't know what to do with the results. This was done about 2 weeks ago and my husband still has not had any symptoms. The doc wanted him to start anti-virals (he thinks it is a false positive but wanted him to do this to prevent passing it to me since my herpes tests were negative) and have him retest in 6 weeks. I told my husband not to start the anti-virals yet because I don't want to muddy the waters further when the test is redrawn.

Does this sound like a false positive? Should he start the antivirals or not? Would love to hear thoughts from anyone. Thanks!

Here's what all the experts in the field of STIs/HSV would tell you:

Ignore the IgM results.

They tell us that they are unreliable and non-specific, and that the IgM-based testing is prone to cross-reactions with other viruses.

Incidentally, with a numeric value of 2.0, it is possible your husband's test results are a "false positive." This applies to the Herpeselect ELISA test kit, because the published index values for that kit have been shown to be skewed. Any value below 3.5 is suspect.

It is more likely to be a false positive since he is without any symptoms.

:wavey:

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