Good technical paper about HSV vaccines, why they've failed and what's on the horizon

[StayingUpbeat 663]

I realize its not exactly cure research but its recent and an interesting read if you're curious why and how the previous and potential vaccines work.

"Towards a Rational Design of an Asymptomatic Clinical Herpes Vaccine: The Old, the New, and the Unknown"

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324142/

[garban 0]

Hi StayingUpbeat,

Thanks for this article. The paper goes to depth about the current research. Epitopes based vaccines may be the future. Lets hope for the best on that.

From what I see the next few vaccines we are looking at are:

Genocea

Agneus

Vical

Coridon/Allied Health Care

Those are all for HSV-2 though. No idea when there will be something for us HSV-1 folks.

[Voyager2 313]

I have genital HSV-2, but I imagine cold sores and genital herpes are equally stressful, just in different ways, so it is interesting that the four companies all targeted HSV-2. It could be because it's the traditional virus that causes the more stigmatized genital herpes and they had to pick one. We should probably ask them.

I think that when any HSV-2 vaccine first shows evidence of really and truly working, the savy business people in charge will set up a separate clinical trial using HSV-1 people. But HSV-1 people should just get the HSV-2 vaccine anyway, as it will already have been proven safe in a phase 1 trial.