I personally would rather go for crispr, as I know myself and maybe most others who know about halford's theravax may find that as potentially a better therapeutic than most other vaccines coming out, and so I would much rather put any further efforts into finding an actual cure.
id be happy to see either, unfortunatly im undiagnosed as im sure the igg's keep being negatives and i dont get OB's. I assume in things like this and any trails currently out there people need proof they have it. would you be doing a money raiser after youve got everything together? I assume that will be a little while. You seem to know your stuff, good to see another person wanting to help the suffering
Thank you, I'm starting to build a website for this as I know people have a lot of questions. Content is what matters so I have a lot to write about. As it stands I have not patented it but know how to leap jump over those with the patents and they're trying right now.
Right now I want to poll what people would actually want.
I'm debating trying to get a human CRISPR trial but know people may back out or it's not funded enough to go forward verse using a proprietary DNA mix in a vaccine vector which can be a cheaper back up plan. You could say one is a potentially cure (with unknown long term risk), the other a therapy that either boosts the CD4/CD8 cells or not (little to any safety issues) to lower or eliminate outbreaks/shedding. Something is better than taking daily pills which don't reduce the lesion severity.
Yep I understand that. I've been doing this on my own for months and have been debating internally seeking others to help as I know people will want to know my background for credibility but I also like everyone else don't like public disclosure for obvious reasons. I will disclose I'm a doctor, but not a medical one, meaning I have an advanced degree and consider myself a private researcher.
As for "mystery fluid" I've also been debating whether people would actually try a vector-CRISPR-Cas9-gRNA, I'm sure you must feel like me as it is so seductive to try CRISPR to be potentially permanently cured when you're having on OB, but then worry about risk.... further I'm not suggesting I'll make it whatsoever. I'd commission it from 2-3 known labs (because of cloning out AMPr to be FDA human use compliant - at least in that respect) who already have the expertise in testing, validating the gRNA, etc. and delivering an aliquot ready for injection. It would take probably 7 months in total to do that and I'm currently reviewing contracts and licensing options to do this and have a lawyer. I'm not saying we need $4 million to build a bio-lab, it can be jumpstarted for a lot less relying in others who have the capacity. Because of patent reasons I still need to get a license for the vector for any commercial sale, and as for using CRISPR I haven't reached out to Temple University which I believe has not sold a license to use CRISPR for HSV-2.
On the other hand I know others may play it safer and may want to just try a DNA-vector vaccine like Frazier's (not intending to infringe his patents) in the Caribbean without waiting a decade for his to come to the USA and wait 10+ years for Temple Uni to valid a CRISPR attacking HSV1 and HSV2 in one (its very hard to do that as I've already been trying with the DNA polymerase gene UL30 and no success.
A DNA vector vaccine can be done with one supplier and is the cheapest and safest method; plus it would be FDA GMP compliant (aka pharmaceutical grade without toxins). It may not cure us totally, but considering the science and 30 years of research I can scientifically point at what to add to boost results from past tries so as to increase the reduction of severity from past results. As for selling it outside the intended country of trials I would need to get a license before the trials for the USA, then patent it after the trial/experiment and apply for FDA testing. Assuming I can make sure legally speaking the trial in the Caribbean would meet a FDA phase 1 standard and allow it to substitute with the FDA.
CRISPR or DNA-Vector?
What would people want to try?
@OhFuckMyDickHurts, @Maybe1day, @crisper, @Peeved - I'd be happy to help.. I ran both crowdfunding campaigns for Dr.Rider's DRACO and built his website (riderinstitute.org) along with a few others.. To date, I've raised over $108,000 for DRACO and so certainly have a few contacts and fairly large email lists that might help. firstname.lastname@example.org. That said, I ONLY raised $108,000 despite having an MIT doctor, a 'cure for all viruses', credibilty via the SENS foundation on the first campaign, news stories (we were featured in Tech Insider, Der Spiegel and other places), active marketing (social, Q&A's, some paid ads, etc..), and a professionally built campaign (video, images) costing $4,200.
Crowdfunding is going to be a tough go and our community is going to have two key questions:
1. How do we know this is credible? (Is the money actually going to get used for what's promised?, What's to stop @OhFuckMyDickHurts from running off with our cash? etc..)
2. How & when will we know if this will be a cure? (Do we know what we're doing? Who are we helping - just genital HSV sufferers? Just genital HSV-2 sufferes? All HSV sufferers?..)
You are talking about science, and we don't need believers in science. The skepticism is healthy.
Whoever you are, we want you to succeed. When you start your campaign, I will donate, and I also volunteer my services as a software developer pro bono, though I'm not sure how much use you have for that.
Understand that most members of this forum are medical laymen — myself included — and although your posts sound convincing, it'd be unwise for any of us to inject mystery fluid into our spines because an anonymous Internet user told us to.
Please send a direct message if you wish to communicate privately.