Immune cells have receptors that go around detecting if cells are of the self or not/foreign/pathogenic. The HSV membrane has surface proteins that make it difficult for the immune cells to detect. ..until it's too late. ICP0, and other genes (can't totally remember), code for surface proteins that make the virion slippery (perhaps). So instead of a teflon coated HSV going around, removing ICP0 makes nicks or open windows on the virion surface for the immune cells to bind to it.
Just like w CRISPR and the whole latency deal, the latent viral DNA is tightly bound up and physically unreachable by the CRISPR. So ICP0 is one contributing factor in physically evading the immune system's binding/detection of it.
Depends on what your standards of a cure are. Some would say "functional" cure.
...But I think all these therapeutic vaccines are worthless. It will be great for some people but others may not have as good of results. And the person still has HSV, a chronic viral infection. Only now, they've given their immune system a heads up on what's going on. But there's still viral DNA producing copies of itself. AND if the vaccine recipient stays up all night, partying, stresses themselves out --> cortisol levels go up --->cortisol is the antichrist of the immune system and basically shuts it down ----> downregulation of immune system then hsv isn't as suppressed, regardless of whether your body better knows what it looks like.
A cure is something that removes the viral DNA along with its influence on the body. Right now, CRISPR is the only thing that's being studied that can hold the title of 'potential' cure.
My boyfriend recently got his test results that he's hsv1 positive but negative for hsv2. He assumes his ex has hsv2, but he is basing that solely on the fact that it was genital and when he asked her what type it was she told him none of his business since they aren't married anymore.
I got my results today and I'm negative for both hsv1 and hsv2. Is there anyway for us to find out where he has hsv1? He said he's never had any genital symptoms but also doesn't remember ever having a cold sore either
Realized I never finished my question. Is one location easier to spread than the other? I don't know if we should assume he has it both locations and take the necessary precautions? I guess I'm just sad that if we don't know where it is we can't have any sexual contact without protection. He can't perform oral on me or sex without risking giving it to me genitally and I can't give him oral without risking it orally.
Hi, I was recently diagnosed and am going through all the same emotions i see here. I was married to an individual who suffers from Anti Social personality disorder for 34 years since the age of 17. Needles to say it was not a walk in the park. I have had no relations with him since October 2014. In april/may and june I was intimate with someone i have known for many years, the condom broke. I started to get symptoms in June and went to GYN thinking it was a yeast infection (I had been taking antibiotics for a sinus infection) I had also gotten a wax 2 days earlier and just thought it was a combination of things. I was shocked when the doctor said it looked like herpes and he did a swab and blood work (positive), my question is, is there any way to tell if it was a recent infection or something that was dormant??
when i left the psychopath I got tested, didnt know then that Herpes was not part of STD testing.
I would really appreciate an input on this, I have my lab test results..which im confused by also
hsv 1 igm screen positive
hsv 2 igm screen positive
hsv 1 igm titer 1:20
hsv 2 igm titer 1:80
hsv 1 igg AB herpesselect 1.63
hsv culture isolated
hsv type 2 isolated
all my doctor said is you have herpes and gave me a script for valtrex (i know I will be looking for a new GYN)
im not sure what type I have...im just confused, can someone please help me with this?
Is it possible that Halford's therapeutic could be considered a cure? Depending on his results, is there any possibility it could reduce shedding enough say 90 percent and eliminate ob's that it could be considerd as such? I've read where it's been said that he will have the best results. Thoughts?
Not really, not in world population terms, plus only those infected are coming to tell their infection stories.
No one comes on here to say "guess what, I had sex and experienced no symptoms and didn't get herpes!"