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First its Positive for HSV2 IGG than its Negaitve for HSV2 IGG, what to think


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free2choose101

So my wife and i both had many risky sexual encounters before we married. We both were tested in 2009 and the results came back negative. In 2012 i started getting sores on my genitals and freaked out. I was tested with the HSV 2 IGG, Type Spec blood test In Sept of 2012 and it came back negative. But in June of 2013 i came in for a follow up and the HSV2 IGG Type Spec test came back positive with a 1.22 score. I couldnt belive it after all this time to get a ding on the +. So i waited for the next sore and near the end of July 2013 i had a swab done, a HSV 1 IGG Type Spec blood test and a HSV 2 IGG Type Spec blood test done. All 3 tests came back negative <.91. What am i to think, Should i get the Western Blot test or retest in a few months the IGG blood test?

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Were these tests from the same kit, say Herpeselect? Different kits may have slight variants in outcomes.

The positive result, particularly from a Herpeselect kit, is a low positive and people in that range especially with no other symptoms (although I note you do) have well over a 50% chance of being negative for HSV-2.

The later test seems to give more weight to the notion you are negative for HSV-2. I feel you can put the issue to rest of this being HSV-2... But not HSV-1.

Clearly sores are an issue, if not for herpes maybe something else. I really feel the best you can do is no more blood tests but to have a swab of any future sores if you are concerned. It's the best way of identifying the type and location of HSV.

There is a chance the sores are the result of HSV-1. For about 1 in 10 people this does not show up in blood testing. Is your wife also free of HSV-1?

In the circumstances of a committed relationship is this really an issue for the two of you? If you've eliminated the real nasties is there a need in both of you to spend effort tracking down whether one or both of you has some less than common issues with HSV-1 (or maybe HSV-2)? Think about it, as it may take quite some time, cost and emotion to identify HSV and then do precisely what with the outcome??

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free2choose101

My wife did test postive for HPVN but its not warts i get, but ulcer looking spots. At this point i just want to find out if i have HSV 2 so i can accept it and do my best to not spread a std to my kid with careless hygiene. I've read of the virus transmitting all sorts of different ways. I feel like im living out the movie Contagion with Matt Damon. My wife was tested 3 days ago but the test have not returned. PS. The Nurse said that once a test comes up positive they always consider you a potential carrier, does that mean im reported to the CDC?

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Did the 2009 tests for you and your wife also explicitly include IgG antibody type specific for HSV-1 and HSV-2? Were you tested at least 12 weeks post sexual contact with any other partner? If the answer to either of these questions is no, then it is possible that HSV is present in either or both of you. Let's assume for the moment that the answers are yes.

It is possible that your first negative HSV-2 test was done too soon after symptoms appeared to identify positive for antibodies, however this seems irrelevant now as you have had two subsequent tests that are in no way a firm positive for HSV-2. Tests are biassed toward producing false positives with other proteins in your blood reacting with the testing plate. A herpeselect score of 1.22 is very low (if that was the kit) and whilst a good indicator to test again, the subsequent negative is more likely to confirm that you do not have HSV-2.

Sexual contact is the key mechanism for transferring genital herpes. Towels, accidental brushing or touching (for a quick scratch of your genitals) then touching someone all carry no appreciable or detectable levels of risk. Standard and sensible hygiene measures will ensure your child does not become infected due to genital herpes.

I suggest that if your wife comes back again negative for all forms of HSV that it may be time to consider a Westernblot, which, as mentioned previously, is far more likely to identify a HSV-1 infection compared to commercially available blood tests.

I can see how the presence of sores is the concern that makes it hard to drop the whole issue even when tests are negative. Do the doctors think there is a chance that they do look like herpetic lesions? Where are they occurring, how long do they last and what is the frequency of recurrence?

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There are reports of people who test positive by IGG and then test again after and got a negative result. In the sample I read about, these people were then tested by western blot which was a clear positive , but the herpesselect stayed negative.

All very confusing. However, your positive was a low positive. Anything over 3.5 is considered a true positive. But, from what I've been learning, there is no test that will say 100% no you don't have it......

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    • vannen2
      Thanks for the answer, Wilson. Sorry for taking long to come back here, didn't really have the time to sit down on my computer and I've been trying to not think much about it.  I took a blood test and I'm waiting for the result. As of now, the redness covers a slightly bigger area and I feel some occasional itches. It definitely isn't herpes but at this point I've already accepted I have something, nothing like this ever happened before and honestly? If anything comes positive, I deserve it.  Maybe I'll come back with a current picture for the people that may end up in this post in the future. I will come back with the results as well, of course! I looked a lot into this forum and other people's stories have certainly opened my eyes to many things in life, so I'm thankful for that too!
    • WilsoInAus
      No problems @AlexUobby those queries are reasonable concerns and I hope these answers give you comfort. Every test has a minimum value (including between HSV-1 and HSV-2 from the same blood sample). This ranges from 0.01 to 0.80 in theory, but in practice more like 0.01 to 0.40. Any value in this range is very likely a minimum value and means an absence of the antibody being tested for. Hence if you get say a 0.3 value on this upcoming test, then the correct interpretation is that it is a minimum value and means no antibodies at all - negative. IgG testing is far from perfect in terms of them being a little too sensitive and generating false positives. This is because although they try and find the best antigen that attracts only an antibody specific to the virus being tested for, this is imperfect and other proteins may be present that attach to the antigen. This is true for all IgG testing. You will also find a very large number of people on this site whose low positives transpired to be negatives.
    • AlexUobby
      @WilsoInAusI know, and I have read a lot of posts recently. And I think I know it better, and it won't just come out on my hand. And I am planning to do another Roche test. The result may come out next week. If it was still positive, does that mean I have herpes? I mean the baseline was 0.06. Or I understand it wrong? And there are still one thing that concerns me so much. In the 6 week test, my HSV I igg was 0.02 and my HSV II igg was 0.06. I know they both were low. I was a little worried that HSV II igg might be on the process of seroconversion, since the HSV II igg was three times large than the other. I know it wasn't logical, but worried. I just don't quite get how they suddenly jump to 1.2 even 1.9 after 6 weeks if there weren't seroconversion. And I saw a lot of people in this forum, and their value almost stay in the same level. And that really concerns me a lot.
    • WilsoInAus
      Hello @Lou_95 and thank you for taking the time and having the bravery to come forward to seek help. I hope you find some assistance and find solace.  What has occurred here happens to many couples and it is important to note that it highly likely that this has absolutely no questions surrounding fidelity etc. The first thing to note is that your assumption is the other way around. When a person has their first herpes outbreak, then it is extremely likely that they have been just infected by the other party. Herpes does not wait around taking its own sweet time to cause an outbreak. When first infected, you are in a sense 'defenceless' against the virus so havoc can be wreaked - well the lesions that you experienced. If your partner is quite sure they have not been infected genitally with herpes in the past, then the most rational explanation is as follows. Your partner may well have an oral HSV-1 infection that causes oral cold sores, even if he has no living memory of cold sores! You hence may have become infected through oral sex about 2-6 days before you noticed the sores. Your diagnosis may have included the type of herpes involved, was it 1 or 2?  If my guess above is right, then you both now carry HSV-1 and cannot technically reinfect each other, or at least give your immune 6 months to get up to full speed. He is now already immune and is incredibly unlikely (if there is any chance at all) of becoming infected genitally). If this is the story, then that's kind if it for you two, no need to worry at all about issues of protection or antivirals etc. However hopefully you have the type data to proceed to that stage quickly. Otherwise it might be useful for an additional test by either you or he or both.  
    • Lou_95
      Hello, I'm new here and was diagnosed with genital herpes 2 weeks ago. I have a lot of questions but dont know where to start. My boyfriend and I have been in a faithful relationship for 6.5 years now, and I just had my first outbreak and he has never had one before. We are unsure of who had it to begin with, I assume it was me considering I had an outbreak first. I feel awkward and weird in my relationship, and sex life now, even though he was very understanding and accepting with the situation. He said it could have been either of us and there isn't anything we can do to change it.. which is true. I dont really know what I'm looking for here, maybe just some advice and others personal experiences with the same situation as myself. 
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