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    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
    • Just a human being
      Try google T cells gut flora encephalitis. Can try to find it if u can’t.  I know Wilso could crack it but it common knowledge and educated on in groups by well respected HSV advocates from organisations that the virus can travel via other nerve routes. Whether this has any baring or truth in your case at all no idea. 
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cheerlove

16 and in need of SUPPORT!

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cheerlove

I am 16 years old and was just diagnosed with genital herpes. Well actually I haven't gotten the call yet but me and my doctor are both sure it is herpes because I have all the symptoms and the sores.

It sucks because it has really changed my life and not for the better. First of all, my birthday is this coming Saturday. Hopefully the outbreak will be gone by then but it sure is inconvenient timing. Even more timing issues, this year I have a full plate. I am in my junior year, the most important, doing varsity cheerleading and an AP science course. You could say I'm under stress.

What I'm feeling right now is a whole mix of emotions. The first initial feeling was: my life is over. The second that I felt was that no one else will ever like me again and even if someone does, there will be complications having children. Now I just feel so much regret. I am filled with constant regret, and sadness or anger. Just when I feel like I can't cry anymore, I cry some more. And this isn't your typical cry, it's a wailing, broken feeling crying. I just can't explain how much I wish this all did not happen. My parents are giving me so much support and help me feel like it's not the end of the world. And the first day back to school I felt almost zen. I felt like relieved for teen issues like drama between cheerleaders. They made me feel normal. But I never maintained that feeling and I'm back to feeling almost depressed. I just really need more of a support group than my parents but I can not have my school knowing or else THAT would be horrible. I still feel so much regret and feeling like no one will ever love me now...

Anyway, anything supportive you could help me with would be highly appreciated.

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Acesheart

Hey Love, welcome to our family. It's normal at first for all these feelings to overwhelm you at once. You just try to stay focused. Does the guy know? Let us know if your h is h1 or h2. H is harder for females to pass. If it's h1 from partner with cold sores, from oral sexy times, this h shouldn't be as problematic as genital h2. Get some Vit.b12 complex for your immune help. This vitamin has has many great benefits. Talk to your doctor first. I'm happy you joined and hope to meet soon. We do have several users here your age, just look in the threads for those post. Hugs sweety, take care and keep us posted. Truly, Acey

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happyreality

Were all about support here. There's not really a certain way your suppose to be feeling but it's all normal emotions. I contracted H when I was 14. I felt scared alone scarred. But don't keep it inside. I was so embarrassed I never told anyone at that age and it just deteriorated my self esteem even more. There's so much help and support. Your NOT alone. your life and future possibilities are not over. Any of them. There's Alot of useful information on this site that will help you manage. Best wishes :)

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Loz3282

Hey there, I'm also 16 years old and just been diagnosed with Herpes! I know ex actually how you feel. I'm having my first outbreak.. It's the worst feeling ever! Constantly burns, itches, irritates etc. I'm on pills that don't seem to be helping. I'm in College and have to take a day off tomorrow cause I can't walk or sit down properly. I can only lay down!

It's horrible! I hope you're okay!

I know how bad it is but hopefully everything ends up fine! Message me if you like <3

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Acesheart

Hi welcome Loz :) . Get you some Epsom salts and a bowl of warm water, mix one tablespoon per cup of warm water. Soak you wash rag in this water and apply to the effected areas. My daughter is in college too, I'm assuming you have no tub correct ;) ? Get some baby diaper rash cream or Zinc Cream for these sores and that irritated area. You can apply the cream to a pantiliner and it helps when you have walk, sit, drive or stand. Don't forget to take ibuprofin for the inflammation. It helps, trust me. I'm a female with ghsv2. for 25 years and I completely understand what your going through. Take care honey, Truly Aces

Hey there, I'm also 16 years old and just been diagnosed with Herpes! I know ex actually how you feel. I'm having my first outbreak.. It's the worst feeling ever! Constantly burns, itches, irritates etc. I'm on pills that don't seem to be helping. I'm in College and have to take a day off tomorrow cause I can't walk or sit down properly. I can only lay down!

It's horrible! I hope you're okay!

I know how bad it is but hopefully everything ends up fine! Message me if you like <3

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