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    • asdfz
      Hi, here seeking advice from those on Famvir for daily suppressive therapy. I’ve tried valtrex and get nasty side effects so I’m on Famvir. I was taking 375 every 12 hours which kept OBs away but I was getting 2 migraines a week. My doc said to try 250 every 8 hours. I’ve been on that about a week and constantly feel tingles. Is that normal when adjusting meds? Will it go away as my body adapts? Please help! 
    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
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Loz3282

16 WITH HERPES - Scared!

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Loz3282

Hey guys!! I'm kinda new to this, made this account yesterday! I've been diagnosed with Genital Herpes about 2 days ago! I know who I got it from and I'm furious at them not because I caught it from them but because I was raped by them. He was meant to be one of my best friends. :( damn!

Im in the middle of my first outbreak! I don't think I've ever been in so much pain! I can't go toilet without crying. I wake up at LEAST 3 times in the night! I wish I never had this. I'm 16 years old aswell. In College. I've had to miss a few days of college because I can't walk or sit properly. None of my parents know. My dad will lose trust in me and mum will go crazy! I'm scared! I wish I didn't have to go through this :( how have you all managed with herpes ?

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jennifertigress

Your 16 and in college already? props for that you must be really smart! Good job:D But I am sorry to hear about your situation. that really sucks. being mad is understandable. did you report them? but first getting this is one of the toughest things to get through. Getting through it makes you a stronger person. in the beginning its really tough but be patient and try to be positive. give it time! Focus on yourself, or maybe distract yourself, focus on schoolwork, or a personal goal or I hung out with my friends a lot the first few days. Did you get pain meds and viral meds from your dr? I hope so:) they help. you don't have to tell anyone that you got this. My parents don't know. If you need anything just ask us:) This site is very helpful:D

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Loz3282

Im from The UK So everyone goes college around the age of 16! I'm struggling a lot to get through this first outbreak because of the pain, but I seem to be managing! Everyone on here have been so lovely to me and made me feel so much better about the situation. I haven't reported him, only because it wasn't violent or anything, I don't want to completely ruin his life because he ruined mine. The doctor gave me Zovirax to take :) thank you xx

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abbykat

Don't freak out! I just found out as well, but I am 21 in college in America. I can tell you that the first outbreak is the worst. Your body needs time to build up antibodies, so in your first year, IF you have another outbreak, which some will produce enough antibodies after the first outbreak, you will have maybe 4 in the first year, then 2 or 3, then none at all. It is important that you maintain perspective. As many people are living with herpes, it is not a death sentence. There is this social stigma associated with genital herpes, just the word "herpes" is automatically associated with a horrifying STD. But everyone has 1,2,3 or more types of herpes that they will have for the rest of their lives, it's really no big deal. You'll be just fine. Most people have had chicken pox which hides in the nerves and returns later as shingles. Most people have oral herpes. Mononucleosis is another incredibly common herpes virus. Your's just happens to be on your vagina and people don't like that because it means, "Hey, I've had sex." It's not medically a big deal, so if you haven't already you'll notice your doctor is not bothered by it. It's almost irrelevant in the medical community, but it has a lot of social implications. You can find support on here, or on dating websites for herpes like a subset of positivesingles.com. Good luck!

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