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girlygirl702

Has anyone seen this

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hsv1owner

Definitely a step forward. I'm interested in this talk about it suppressing replication. That's a big win if so.

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throwawayday345

This is an old article from January 2014 about Pritelivir, which was discontinued.

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StayingUpbeat

Depending on your tendencies toward conspiracy theories it was because of either the official reason: it caused kidney damage in monkey that were given a 20x dose or the conspiracy theory: that it would be a competitor to Valacyclovir.

In any case a nearly identical drug called Amenamevir is in phase III trials in Japan: https://clinicaltrials.gov/ct2/show/NCT02209324

and probably going to be marketed for use with HIV patients in the UK:

https://clinicaltrials.gov/ct2/show/NCT02223351

https://clinicaltrials.gov/ct2/show/NCT02321748

(the co-study drugs in these trials are both for HIV)

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throwawayday345
Depending on your tendencies toward conspiracy theories it was because of either the official reason: it caused kidney damage in monkey that were given a 20x dose or the conspiracy theory: that it would be a competitor to Valacyclovir.

In any case a nearly identical drug called Amenamevir is in phase III trials in Japan: https://clinicaltrials.gov/ct2/show/NCT02209324

and probably going to be marketed for use with HIV patients in the UK:

https://clinicaltrials.gov/ct2/show/NCT02223351

https://clinicaltrials.gov/ct2/show/NCT02321748

(the co-study drugs in these trials are both for HIV)

I didn't know that, that Amenamevir was considered similar. Is Amenamevir a vaccine? I thought it was a pill that had similar results to Valtrex, what would be the differences if it came out?

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StayingUpbeat

Pritelivir is a pill too. They both fall into the same class of potential drug called Helicase Primase Inhibitors HPIs. They target a different aspect of virus than the nucleoside analogs (acyclovir, famciclovir, valcyclovir, etc...). The HPIs have had a mixed safety profile in testing. Astellas, the company that developed Amenamevir, pulled it during human trials because of kidney toxicity. Agenus, the developer of Pritelivir, pulled it during phase II trials also for kidney issues (though it was due to animal trials being run concurrently with the human trials). It's unclear why Amenamevir has been resurrected but there seems to be an angle that involves it's use to control herpes in people with HIV.

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