Newly published thesis on immunization approaches & molecular signatures

[Evaluate]

http://www.healthcanal.com/sexual-health/64680-next-step-toward-a-vaccine-against-genital-herpes.html

https://gupea.ub.gu.se/handle/2077/38383

A doctoral thesis by Dr. Persson, from the University of Gothenburg in Sweden, looks at immunization approaches (needle or nasal) and two other things that I can't make heads or tails of for tackling genital herpes.

1) I was wondering if anyone knows why, to the best of my knowledge, nasal methods of a HSV vaccine haven't been looked at? Would it make a difference in results; is there minimal research available, leading to it not being considered; etc?

2) Would someone be able to translate (from science to layman) the other two points the thesis makes? Something about "Nasal and skin immunization with recombinant HSV-2 gD antigen in combination with the clinically tested adjuvant IC31® was highly efficient for induction of specific B and T cell responses and protection against primary genital herpes in mice" and "Identification of local inflammatory imprints connected to immune cell recruitment after vaginal immunization with live attenuated HSV-2 in mice."

[Gothic Beauty]

Well if it had to be in layman terms I guess I would say for the first part of your #2 is that it creates a immune response & offers protection and the second part of your #2 would be stating where inflammation happens because of the vaccine.