Jump to content

Any scientists working on a vaccine for HSV1?


bayern77

Recommended Posts

I was just noticing there are many scientists working on different methods of trying to figure out a vaccine for hsv-2 sufferers, but I was wondering if there are any current clinical studies for hsv1? I have always asked myself how much different is hsv1 from hsv2 , since I know the virus is not as aggressive .

On the same note, would a hsv2 vaccine benefit or have any effect for hsv1? I know there are a lot of people saying hsv1 is not a big deal but in my opinion herpes is herpes. The stigma is the same especially if you have it downstairs. I suffer from Ghsv1 and I must admit it has changed my life in many ways. In reality how much does it benefit if there was to be a vaccine for hsv2 would it help out those who suffer from hsv1? since I've hears some proteins are from the same dna.

I have also heard about some study from Duke which was conducted in 2008 , where they noticed that certain proteins were enough to cure females from acquiring hsv1 if they had never had a cold sore in their lives. Does anybody know what happened to this study?

Thank you very much.

Link to comment
Share on other sites

The hpi med from Japan is for both strains. Phase 3 trials is complete! The thing that is neat about med is that it is to be taken once a week. That would bring a sense of normalcy to h sufferers.

Link to comment
Share on other sites

The hpi med from Japan is for both strains. Phase 3 trials is complete! The thing that is neat about med is that it is to be taken once a week. That would bring a sense of normalcy to h sufferers.

Excuse my ignorance but is this the same thing as the HSV529?

Link to comment
Share on other sites

I tell you what, the Japanese know how to get things done.

I worked in a lab and my supervisor was from Japan. He would come in at 6am, work work work, lunch while reading articles, work work work, pick kids up from school, have dinner, come back to the lab for a little longer and then go home, sleep and repeat. I have some friends who did some research over in Japan and everyone remarked on how incredibly productive they, as well as everyone else, was over there.

They made the Chicken Pox vaccine.... They partnered with Frazier to make Gardasil...

But back to this drug they're making. I read something about it but now is the first time I've actually read a paper about it. I'm not a fan of Valtrex. I've never taken it. But IF I WERE TO TAKE SOMETHING, this drug that the Japanese are producing is one I would stock. It really is amazing. They're comparing toxicities of Valtrex and it's outrageous how benign the Japanese drug appears to be. And lightyears greater in efficacy!

Here's a link to the paper.

http://www.mdpi.com/1420-3049/16/9/7210/pdf

  • Like 2
Link to comment
Share on other sites

I tell you what, the Japanese know how to get things done.

I worked in a lab and my supervisor was from Japan. He would come in at 6am, work work work, lunch while reading articles, work work work, pick kids up from school, have dinner, come back to the lab for a little longer and then go home, sleep and repeat. I have some friends who did some research over in Japan and everyone remarked on how incredibly productive they, as well as everyone else, was over there.

They made the Chicken Pox vaccine.... They partnered with Frazier to make Gardasil...

But back to this drug they're making. I read something about it but now is the first time I've actually read a paper about it. I'm not a fan of Valtrex. I've never taken it. But IF I WERE TO TAKE SOMETHING, this drug that the Japanese are producing is one I would stock. It really is amazing. They're comparing toxicities of Valtrex and it's outrageous how benign the Japanese drug appears to be. And lightyears greater in efficacy!

Here's a link to the paper.

http://www.mdpi.com/1420-3049/16/9/7210/pdf

Wow this sounds like great news! , Thanks for the link. I also read that people who have hsv2 demonstrated their shedding was significantly reduced down to 2% or less. Realistically do you think this will get approved? and if it does get approved, when do you predict it will be released to the general public? I wish they could give us more data on how much it significantly reduced shedding compared to Valtrex.

It seems this will be the next big thing close to a functional cure. If you can get hsv2 sufferers to be shedding 2% or less , I'd say it is big news . This seems like it will be the preferred effective method to stop transmission or lower it to 1%.

Link to comment
Share on other sites

Wow this sounds like great news! , Thanks for the link. I also read that people who have hsv2 demonstrated their shedding was significantly reduced down to 2% or less. Realistically do you think this will get approved? and if it does get approved, when do you predict it will be released to the general public? I wish they could give us more data on how much it significantly reduced shedding compared to Valtrex.

It seems this will be the next big thing close to a functional cure. If you can get hsv2 sufferers to be shedding 2% or less , I'd say it is big news . This seems like it will be the preferred effective method to stop transmission or lower it to 1%.

Yeah, it really sounds too good to be true. Buuut, thooose Japanese!!!!! ^_^ hehehe bless their hard working souls! My prayers go out to them :)

No idea how long it'll take to get out. I was just freshly infected 4 months ago. All this material world vaccine modern research science goes sooooooo daaaammmnnn sloooooooowwwww... The best thing is to pray and give thanks to the souls working on this stuff and that the forces that be enhance the speed at which things are available to the people.

Haha, somewhere in the article it compares viral shedding detected by either of the drugs. Valtrex was noticeably there, while the ASP drug showed "below detectable limits".

Link to comment
Share on other sites

Im curious to see if a combination of this HPI from Japan and current antivirals could completely stop shedding. Or even a somewhat effective vaccine like Genocea or potentially stronger vaccine from Admedus and HPI could do the trick? I think it is possible!

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Donate

    If Honeycomb has helped you, please help us by making a donation so we can provide you with even better features and services.

  • The Hive is Thriving!

    • Total Topics
      72.1k
    • Total Posts
      486.1k
  • Posts

    • WilsoInAus
      I really suggest that the best thing is for both you and your boyfriend to obtain the Westernblot HSV test. He has a 50%+ chance of being positive and you have a 50%+ chance of being negative. Only the Westernblot can sort this out for you.
    • WilsoInAus
      Hi @kpn the first thing to note is that it is all OK to have HSV-1 or indeed any HSV type. It is not negligence, it is just being human. Oral HSV-1 is not an STD in the sense that the primary transmission is non sexual and the majority of it occurs between parents to children. If any of your children contracted HSV, you would know it. It wouldn't be a silent infection for children. HSV-2 tends not to shed from the oral region for people who have it there in any event. At age 73, about 80% of the population has HSV-1. There is no reason to believe that your mother isn't one of those people. About half of all carriers of oral HSV-1 do not realise they have it and have no living memory of cold sores as they were infected when very young. The most logical explanation is that your mother has oral HSV-1 from her childhood and that your daughter doesn't have oral HSV. Not that it is relevant to anyone but yourself, but your wife might find she actually has genital HSV-1 having had an untyped swab when she was diagnosed.
    • WilsoInAus
      Hi @Dylan86 and welcome to the website. First note that you cannot pragmatically become infected with HSV-1 from sharing a drink. If you carry HSV-1, it did not come from that episode. As such it is extremely unlikely HSV-1 is the primary cause of your issues. Can the WB miss a HSV-1 infection? Rarely but its feasible in less than 1% of carriers who test with WB. Note that the WB does not have values, it has positive or negative as you say. It is way more accurate than IgG as it looks for all 30+ antibodies that are in your blood for HSV. Could you have HSV-1? Yes it is feasible, but it would be a very old childhood infection. Could HSV-1 be causing your oral issues? No herpes will not cause the burning mouth syndrome you describe. Could some of the lesions be herpes related? It is feasible if you are a carrier. But it is unlikely to be the primary cause of the issues, but its an opportunistic virus that can cause issues when something else is taxing your immune system. The best thing you can do is the PCR test on a oral lesion and that will be pretty definitive. Either way, in summary. I'd suggest there is <1% chance you are part of about 70% of the population that has HSV-1. Further there is less than a 1% chance that herpes is the primary cause of your issues.   
    • kpn
      My wife has had hsv 2 for around 8 years. We have two young children 3 years old and 18 months old. My wife only had one outbreak when she was first infected so we didn't worry too much about passing it on to our children. I understand the risk to be pretty low under those circumstances. I don't believe my wife took antivirals during either pregnancy. My younger child has diaper rashes pretty often and has had what I thought was hand foot and mouth disease. That was going around the daycare a while back. I haven't really given it much concern though.  About a week ago, my mother kissed my youngest on the lips. My kid was congested at the time but they pretty much always are. About 3 days later, my mother developed a cold sore on her mouth. She has never had cold sores in her life and she is 73 and happily married so she is not going around messing with anyone. She pointed to the fact she had kissed my youngest and presumed that is where she was infected. At first I said that's not possible since my child has never had any cold sores but since then I have really started to consider that maybe it is possible she contracted it from my daughter. This has me worried that my daughter does indeed have hsv2 and was shedding in her mouth. Does anyone have any experience with this? I am really losing sleep about this. Two people I care so much about got hsv from my negligence. I am fine if I were to contract it, I am not worried about what others think at this point in my life. I just don't want anyone else to have it. 
    • CHT
      Hello DavidGua.... based on the two pictures, I'm not seeing anything that resembles a typical herpes outbreak.  I am not sure what those spots are on your penis.  Please have a doctor take a look and I'm sure you'll get a proper diagnosis.  Have you ever received an HSV antibody test (IgG)?  Again, I doubt your symptoms are herpes-related but, if you'd like some peace of mind, you could request the IgG antibody test for HSV2.   Best of luck.... let us know if you have any other questions/concerns.
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.