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So, how many vaccines are in the works right now?


AychEsVee

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Haven't been here in a while, seems there's been significant, encouraging progress. I know it's very lazy, but could you guys help provide a laymen's summary of what's been going on with HSV vaccines?

 

In the works being, whether being speculated, studied or actually in trial.

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There's a really good wikipedia site that lists all of the research being done on herpes, including vaccines. It's updated pretty frequently, as per wikipedia standards ;)

 

https://en.wikipedia.org/wiki/Herpes_simplex_research

(The thread that originally posted this link is pinned to the top of the "Herpes Cure Research" forums.)

 

Based on the wiki article, there are a total of 9 vaccines currently in the works. Of these vaccines, 2 vaccines have made decent progress: Admedus' vaccine (Phase 2 trials), Genocea's vaccine (GEN-003 in Phase 2 trials).

The replication defective vaccine (AKA dl5-29, or ACAM-529, or HSV-529) is in Phase 1 trials (expected to be complete by October 2016). The live attenuated vaccine by Halford is not undergoing any trials because of lack of funding.

 

Hope that helps!

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  • 4 weeks later...

Aside of the usual vaccines being talked about here.. what did happen regarding the Agenus Herpv vaccine ? Dead yet ?
They must be hiding disappointing results cause their stock values would fall etc. :D

Edited by Juggalo
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Aside of the usual vaccines being talked about here.. what did happen regarding the Agenus Herpv vaccine ? Dead yet ?
They must be hiding disappointing results cause their stock values would fall etc. :D

Yea, its dead. 

This is what really concerns be with Amadeus and Genocea. Herpv reported similar results to Genocea, and similarly people were excited, but it was canned due to not being effective enough to bother with. 

This means Genocea, and even Amadeus are almost sure to never make it to market. They made a live replicating defective vaccine, that caused an over 80% drop in viral load, and that wasn't good enough to make it to market. The idea that Genocea is exciting or could become a legit product to help us, seems ridiculous and way too optimistic. 

Edited by Herbfresh
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Agenus vaccine is likely to be crap. They just hide and creep out the results, so to not crash their market value.

 

Anyhow, the phase 2 Frazer Admedus vaccine results are supposed to be coming out soon, nearing the end of the year so they can be compared with Genocea vaccines results.

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 This means Genocea, and even Amadeus are almost sure to never make it to market. They made a live replicating defective vaccine, that caused an over 80% drop in viral load, and that wasn't good enough to make it to market. The idea that Genocea is exciting or could become a legit product to help us, seems ridiculous and way too optimistic. 

Hey, hold up.

 

Who made a vaccine that caused over 80% drop in viral load? Can you provide your source?

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Hey, hold up.

 

Who made a vaccine that caused over 80% drop in viral load? Can you provide your source?

he is just a noob, who mixed up scientific terms and words, after reading upon the wikipedia article..

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he is just a noob, who mixed up scientific terms and words, after reading upon the wikipedia article..

A noob is infinitely better than a retard who doesn't understand basic grammar, or have the ability to write actual sentences.
 

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Hey, hold up.

 

Who made a vaccine that caused over 80% drop in viral load? Can you provide your source?

I can't remember the name of it. Somebody posted the link here, a while back. It's some late 90s canceled vaccine, based off a live virus. And yes, it did achieve those results. I'll browse around and try to find it. 

There's no reason to be surprised they would abandon such a thing. HerpV got good results, up to a 75% reduction in viral load, although I don't think that was the average. Well, HerpV is finished. They are not making the vaccine, despite those results.

These subunit vaccines aren't achieving the results needed to take them to actual products. None of them have been particularly promising in human tests. Just a merry go round of disappointment and time wasting. All the current subunit vaccines in development including Ademdus are useless. A live vaccine is obviously what they should be focusing on. I have hope in the replicative defective one in development.  

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There's no reason to be surprised they would abandon such a thing. HerpV got good results, up to a 75% reduction in viral load, although I don't think that was the average. Well, HerpV is finished. They are not making the vaccine, despite those results.

HerpV reduced 75% in viral load, for those who suffer HSV-1 but only 15% reduction in outbreaks. 

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37 minutes ago, mcmich said:

Aurx developed a weakened virus, made it through Phase 2 testing, did not have enough money to complete Phase 3. Think this is what he is talking about!

http://www.aurx.com/

 

If they were to get funding, would they pick up from where they finished, at phase 2, or do they have to start from scratch? Or is that it, once research is kaput, they never resurrect it? 

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On Sun Nov 1 17:50:24, Sillybrain2 said:

If they were to get funding, would they pick up from where they finished, at phase 2, or do they have to start from scratch? Or is that it, once research is kaput, they never resurrect it? 

Aurx is done. They were last relevant about a decade ago. They actually were smart and ballsy enough to hold trials out of the country in Mexico which is what Draco and Halford should be doing since they can't get sufficient funds. Halford seems to be finally getting with it as far as funding goes. Aurx had somewhat impressive results and is a very similar vaccine to what Halford has.

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13 minutes ago, dont quit! said:

Aurx is done. They were last relevant about a decade ago. They actually were smart and ballsy enough to hold trials out of the country in Mexico which is what Draco and Halford should be doing since they can't get sufficient funds. Halford seems to be finally getting with it as far as funding goes. Aurx had somewhat impressive results and is a very similar vaccine to what Halford has.

Such a shame isn't it? If Halford or Draco were to take their work outside of America, with the rights funding etc, could trial and testing periods be fast tracked and shorter than what is required in the states? I really feel like all these labs and researchers need suffered of HSV to get in and move them all along! If only it were that easy to shout 'GET A MOVE ON.' So many people need this!

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Aurx would restart the trials if it had the funding but I think he has given up. I actually e-mailed the ceo/scientist and he replied that he would start Phase 3 up if the funding existed but he is no longer pursuing it. I think he is getting up in years and has given up. 

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2 hours ago, mcmich said:

Aurx would restart the trials if it had the funding but I think he has given up. I actually e-mailed the ceo/scientist and he replied that he would start Phase 3 up if the funding existed but he is no longer pursuing it. I think he is getting up in years and has given up. 

I had also e mailed Dr. Aurelian, she also said, she was getting old but was pessimistic of starting a phase 3 trial. She said, phase 3 would be estimated at 10 million, which is a hell of a lot cheaper than holding a phase 3 trial here. If anything, Aurx passing phase 1 and 2 proves that a live vaccine is indeed safe.

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7 hours ago, Sillybrain2 said:

Such a shame isn't it? If Halford or Draco were to take their work outside of America, with the rights funding etc, could trial and testing periods be fast tracked and shorter than what is required in the states? I really feel like all these labs and researchers need suffered of HSV to get in and move them all along! If only it were that easy to shout 'GET A MOVE ON.' So many people need this!

It would be shorter and much more efficient. The US government in general drag their feet to get anything done; just look a these politicians, they can't even pass a damn budget, smh.

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On 2 November 2015 03:46:20, tom343 said:

This is a documentary on HIV and the Berlin patient but the same scientific principles here imo apply to hsv, with the right DNA modified vaccine, they can get rid of hsv in the same way. 

http://m.youtube.com/watch?v=BgxQDJRUL5Q

 

They had to give her extreme chemo therapy for leukaemia, and they gave this patient a bone marrow transplant from someone who is HIV resistant, so the bone marrow transplant actually gave Berlin patient and new immune system since the chemo had essentially killed his old one. 

But heres the thing without the chemo to kill your old immune system, the bone marrow transplant would not cause your old immune system to be replaced. 

they actually just cured a girls caner with injected designer immune cell systems through gene editing. This could functionally cure HSV. It won't be done in our life time probably as HSV is not deemed important enough. But the cure is out there. 

What were Arux results like?

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