Taiwan testing anti-HSV monoclonal antibody (How did this one slip by)

[StayingUpbeat]

It would appear that United BioPharma is performing a phase I trial of a monoclonal antibody injected under the skin in Taiwan.  It would seem this is a therapeutic not a cure but I'm still trying to figure out:

1. Where this came from
2. What it does

Development Overview

Introduction

United BioPharma is developing UB 621, a subcutaneously administered monoclonal antibody, for the treatment of herpes simplex virus infection. A phase I trial in healthy volunteers is planned in Taiwan.

Key Development Milestones

Preclinical development of UB 621 is underway in Taiwan (United BioPharma website, May 2015).

United BioPharma is planning a phase I study to assess the safety, tolerability and pharmacokinetics of subcutaneously administered single dose of UB 621 in healthy volunteers (NCT02346760; A101-HSV). This open-label trial intends to enrol 12 participants in Taiwan.
http://adisinsight.springer.com/drugs/800042498

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Edited October 1, 2015 by StayingUpbeat

[Random girl]

Thanks for that. The more trials I read about, the more confident I feel there will finally be other treatment options! 

[Broken_14]

@StayingUpbeat... What information have you found out and how do you know this won't be a cure? 

[StayingUpbeat]

@StayingUpbeat... What information have you found out and how do you know this won't be a cure?

Antibodies don't persist for the long term unless they are created via vaccination. Also, unlike something like BavItuximab, it doesn't appear to be the type of antibody that kills infected cells.  UB-621 appears to simply bind with a surface glycoprotein on the viral envelope.

[Broken_14]

I was told that Bavltuximab would not be a cure by Anna Wald. 

[StayingUpbeat]

I was mentioning it as the difference between a cytopathic antibody (i.e. one that targets cells with a particular surface antigen for elimination) and a foreign object antibody (targeted to an antigen that is on the surface of something like a virus). 

Although Anna Wald does a great service for sufferers through her work I would be surprised, given her public comments, if she believes that anything currently in development (including DRACO) would be a cure for HSV.

Edited October 2, 2015 by StayingUpbeat

[Broken_14]

She's already made it clear that she does NOT believe there will be a cure for this virus in my life time and I'm 29. And honeslty, I don't believe she wants there to be one. That's just my opinion. 

[Gothic Beauty]

Right? I agree with Broken_14.

[Sanguine108]

Anna Wald is an interesting person.  I see her and I'm intrigued by the person she is.  I think she means well and the fact that you're able to send her a message that she'll respond to is amazing.  But also that she probably corresponds with so many people around the world that it seems difficult for her to not come off as rude or annoyed.

I do think that it's an obnoxious thing to dwell on.  If a cure comes, it'll come.  I've dedicated more of my energy into spirituality, understanding herbal medicine (and beyond) and working with people so they can cope and live with this instead of gripe with it. 

In the end, we will leave this body behind and our soul moves on.  But if we are able to constantly grow and cultivate our soul then we shall continue thereafter.  If what we're continuing is a practice of obsessing for a cure and never getting over and coming to terms with this condition then one could argue that one would repeat those situations again...  If you don't learn the lesson from something then you're bound to repeat it.  don't let herpes stunt your soul's growth.  This is just one lifetime.  The closer you introspect and get with God then HSV doesn't become as big of a deal.  

Then again, you would need to change your beliefs or be open to an alternate belief/path outside the one you're on.  The best way to see that path is to start by sitting in silence every day for at least 5 minutes.  Start a meditation practice.  With that, you'll metaphysically enhance the speed of researchers and will have earned that "cure" in this lifetime.  This is all conjecture... but I believe it.  I've seen it, experienced it, it's hard to doubt how powerful something so simple is.  give it a trial run for 21 days.

[bayern77]

I refuse to believe there won't be a functional cure.  Medicine has advanced so much and I  have faith it is not too far away. 

[throwawayday345]

This thread needs some perspective. Will there ever be a pure cure for people with HSV? Perhaps not. Why? For the same reason why there are still people in the U.S. who still are technically infected with polio. Once the general population is protected, the fear collapses and we collectively move on.

Does anyone worry about polio anymore? No. Does anyone have to worry about polio transmission? No. Do we even think about polio anymore? No. Because with proper vaccination these risks fell apart. And likewise, soon enough there will be a vaccine that can have the same effect on herpes, and no one will worry anymore. While I do believe we'll also be able to dramatically reduce symptoms soon (pritelivir, vaccines like GEN003 and others have proven this) we need to not be so hung up on a pure cure. 

 

 

Edited October 5, 2015 by throwawayday345

[Sanguine108]

I agree.  I've already accepted this virus.  Just give my body some extra insight about it (vaccine) so it can suppress it more easily and work smarter instead of harder.

Edited October 5, 2015 by Sanguine108

[dont quit!]

I refuse to believe there won't be a functional cure.  Medicine has advanced so much and I  have faith it is not too far away. 

I believe the technology is there but I'm pessimistic about those rat bastards in the FDA. Unfortunately in a sue happy place like the United States, progress takes a damn long time! Sooner or later, one of these developing countries or second world countries will hopefully/probably be a stable for inexpensive, efficient clinical trials. If we are lucky we will live to 60-65 years of age; so waiting for a damn cure while waiting for clinical trials which take up to 15-20 years blows to the highest degree. If it is meant to be, it is meant to be, if not we have to accept it as uncomfortable as the situation gets!

[Broken_14]

 

 

Anna Wald is an interesting person.  I see her and I'm intrigued by the person she is.  I think she means well and the fact that you're able to send her a message that she'll respond to is amazing.  But also that she probably corresponds with so many people around the world that it seems difficult for her to not come off as rude or annoyed.

I do think that it's an obnoxious thing to dwell on.  If a cure comes, it'll come.  I've dedicated more of my energy into spirituality, understanding herbal medicine (and beyond) and working with people so they can cope and live with this instead of gripe with it. 

In the end, we will leave this body behind and our soul moves on.  But if we are able to constantly grow and cultivate our soul then we shall continue thereafter.  If what we're continuing is a practice of obsessing for a cure and never getting over and coming to terms with this condition then one could argue that one would repeat those situations again...  If you don't learn the lesson from something then you're bound to repeat it.  don't let herpes stunt your soul's growth.  This is just one lifetime.  The closer you introspect and get with God then HSV doesn't become as big of a deal.  

Then again, you would need to change your beliefs or be open to an alternate belief/path outside the one you're on.  The best way to see that path is to start by sitting in silence every day for at least 5 minutes.  Start a meditation practice.  With that, you'll metaphysically enhance the speed of researchers and will have earned that "cure" in this lifetime.  This is all conjecture... but I believe it.  I've seen it, experienced it, it's hard to doubt how powerful something so simple is.  give it a trial run for 21 days.

Like most people, I have struggled with my faith on and off all my life. There have been certain situations in my life that has made me doubt the existence of God and there have been situations when I believe there is a God. After contracting this virus due to someones selfish actions and being taken advantage of.. I became angry with myself and God. Then I decided to trust in Him and started going to church, got saved and then baptized. I pray every night and day for a cure. I have fasted in prayer and only drank water, I have had hands laid on me. Nothing has changed how I feel about this virus or wanting a cure. With that said, I have prayed every night for DRACO and Dr. Rider. After the DRACO fund got shut down because Draper decided to cut certain programs and DRACO was one I became discouraged again. However, in early spring I started exchanging emails with the individual that I am now working on the campaign with. At first, we had NO way of getting in contact with Dr. Rider and had talked about going to Boston and searching for him. I prayed and prayed and finally we lucked up, we got his email address. We started to exchange emails with him and we came up with the idea to start the campaign. This has been in the works since the spring. Don't get me wrong, I still have days I get very discouraged, cry, and ask why. I become angry. Resentful. Bitter. But then I remember how far we have came on this campaign. Just to think in March, we had NO way of contacting Dr. Rider and now the campaign launches TOMORROW. When we started talking to Dr. Rider about the campaign, we didn't know which virus he would choose to test. We had decided that if he didn't choose HSV, that we would ask him too. I prayed and prayed about it. And he choose HSV, we never had to ask him too. I'm not saying this is or isn't God answering my prayers but sometimes it feels like it is. 

If Dr. Rider didn't believe that DRACO would be effective against HSV or the hepres family viruses then he wouldn't have picked it. He's a genuinely nice person who wants to help change the world and end viruses. He's just lacked the funding. But if we are able to reach people and Dr. Rider can receive the funds he needs to progress DRACO and test it in HSV then we will shortly know whether or not it's a true cure. Myself and a team of individuals believe in DRACO and Dr. Rider and are working hard to make this a reality for everyone but of course we need help. 

On another note, I'm happy for those individuals that have accepted this virus and have moved on with their lives. However, I can't. I refuse too. This virus has torn my life upside down and I'm a fighter so I'm fighting. Maybe I'm fighting for nothing but maybe my fight to get DRACO funding will end up paying off for not only myself but the millions of people that need it (or want it). I'm fighting for a better world, for love, for my life to be back to normal, to have a deeper appreciation of my life  and my health and I'm fighting to provide my kids with a family they deserve. Please fight with me.

We can't predict the future and don't know how things will turn out. We can all sit around and assume and argue about what we think will happen and if something will or will not work but without testing we won't know. 

Edited October 5, 2015 by Broken_14

[oneday]

She's already made it clear that she does NOT believe there will be a cure for this virus in my life time and I'm 29. And honeslty, I don't believe she wants there to be one. That's just my opinion. 

While I respect all scientists who contribute to hsv research I believe in the "impossible" and I just can't wait for the day scientists who talk smack about there ever being a cure eat their words

Edited October 6, 2015 by oneday

[Broken_14]

Looks like the campaign got pushed back till October 13th but we agreed as a team that this was for the best. However, here's the video that will be part of the campaign. Hope you guys enjoy. 

[oneday]

This is great!! We're privileged to have such an awesome Dr on board to combat viruses, we're totally behind him. Lol a fan of Star Trek much? Thanks for posting video!

Edited October 6, 2015 by oneday

[Sanguine108]

I'm excited that he's taking the initiative to rent a space out for a lab to work on this.  At least donations made to this won't be washed and flushed down the bureaucratic poop shoot!

[dont quit!]

Nice video, thanks for sharing and your hard work! There are no guarantees, but you should feel good about yourself.

[Broken_14]

Thanks everyone. It's been a roller coaster ride for sure and I was bummed the campaign didn't launch today but we've worked hard as a team and thought it was in the best interest to wait till next week in hopes we will have a better chance and raising the funds Dr. Rider needs.