Confused

[Cinderellathefake]

So im no doctor or scientist.

but if theres a vaccine for chicken pox, & u could already have had H from had having chicken pox in the past shouldnt that mean, the vaccine that works for the chicken pox - work on H aswell since it stems from the same anitbody or whatever .. 

Correct me if im wrong. 

[VVK]

I'm no doctor but I used to be a scientist.

chicken pox is similar but still quite different from HSV-1 and HSV-2, so no - the immune response is specific for each virus and there are unique antibodies for each virus

however...

https://www.dovepress.com/efficacy-of-the-anti-vzv-anti-hsv3-vaccine-in-hsv1-and-hsv2-recurrent--peer-reviewed-article-OAJCT

the above article does suggest that the chicken pox vaccine could be protective against HSV-1 and HSV-2 outbreaks.

You might be onto something here Cinderellathefake....

[vzhe]

That paper has been refuted numerous times. It doesn't work. Lots of people have tried all kinds of types of injections. I know of someone who got the chickenpox vaccine 3 months before contracting GHSV, so it's not protective either.

[VVK]

@vzhe do you have an article to back up your claim? or are you basing your opinion on common knowledge?

[vzhe]

Just search the various herpes forums for endless threads of people trying this, to no avail. At this point hundreds of people must have tried.

And on top of that I personally know someone who got the vaccine 3 months before getting a primary hsv2 infection. If the VZV vaccine had cross-reactive antibodies, this wouldn't have been able to happen.

The combination of no success on the forums for the treatment attempts, and no plausible mechanism of action (because the vaccine does not create cross-reactive/protective antibodies even short-term right before challenge) very effectively refutes the paper.

Wish it was true.

Edited November 5, 2015 by vzhe

[Cinderellathefake]

I was just really curious as if this could be a solution. Im not saying im correct or anything. I respect everyones opinion on my topic. But if it does happen to be protective against the virus, can i take the vaccine & hope to see that? I dont wanna be a lab rat but i just want to see ...

[vzhe]

It doesn't work. I know people who tried. It doesn't even work as a placebo.

There are vaccines that do work and reduce symptoms, and they are recruiting for trials right now, or will be recruiting soon. But the VZV vaccine doesn't work. I wish it did.

[Cinderellathefake]

Awww :-( that sucks. Ive had the chicken pox vaccine all the time that even 19 years later i still never got it. I wish it worked for this dumb virus. 

[WilsoInAus]

Well there isn't anything stopping you trying. I would agree there is no proof. We have no idea what the people in the trial did in addition to taking the vaccine. Likely they improved their diet, exercise regime and so on. That study wasn't even placebo (that is, they should have injected everyone on the basis they were having the vaccine with half getting saline).

Nevertheless, it has been shown that injecting an altered HSV (1 or 2) virus does little if anything as a vaccine against HSV (1 or 2) so why would an altered Zoster virus be effective at all?

[StayingUpbeat]

This goddamn dove press paper pops up in the strangest places.  There was an entire threat of people in the cure research forum who tried and reported on their experience trying the VZV vaccine against HSV-2.  There was not a single person who reported a reduction in symptoms. 

The good news, as @vzhe stated, is that if you're looking for a therapeutic vaccine there are several currently in the works and a new clinical trial for one in particular (that has been clinically shown to reduce symptoms) starting any day now at sites all over the US: https://clinicaltrials.gov/ct2/show/NCT02515175?term=GEN-003&rank=3

If that wasn't good enough, unbelievably, the CEO of the company developing the vaccine regularly answers questions on a thread in the cure research forum: http://honeycomb.click/topic/64217-genocea/?page=4#comment-370509

To boil it down to the level of a bumper sticker:

Forget the VZV vaccine (it doesn't work) sign up for GEN-003

Edited November 5, 2015 by StayingUpbeat

[vzhe]

9 minutes ago, WilsoInAus said:

Nevertheless, it has been shown that injecting an altered HSV (1 or 2) virus does little if anything as a vaccine against HSV (1 or 2) so why would an altered Zoster virus be effective at all?

Actually an altered HSV (1 or 2) virus should be almost 100% protective. Where did you hear otherwise?

[VVK]

Ok I sense that this is about to get imminently derailed as a subunit vs. attenuated vaccine discussion. It's a horse that has been beaten to death and back to life again somehow, numerous times.

My challenge in this topic is this: do we know, for a fact, that the people who have allegedly tried this approach (the alleged hundreds of people in forum discussions) have done so according to what the cited study described?

"One standard intradermal injection of anti-VZV vaccine was administered consistent with the dermatological requirement to stimulate skin cell-mediated immunity using the same anti-VZV vaccine (Oka Merck strain), being either Varivax® (sanofi-aventis, 0.5 mL/dose) or Varilrix® (GlaxoSmithKline, 0.5 mL/dose) ..."

Did they all get the same vaccine and was it administered prior to or after acquiring HSV? Was it a first-time exposure to anti-VZV for all of them? How many years did the testers wait before determining whether the vaccine worked or not? Is there only one vaccine and is it always made the same way? I'm asking these questions - and there are many more - because there's a scientific way to disprove a paper and then there's random chaotic trials on the Internet that accomplish chaotic results.

As Wilso said, there's nothing stopping someone from trying this approach.. well, that is assuming that one can narrow down exactly what the anti-VZV vaccine was that was used in 2005. Can we somehow find out what it was and whether something has changed since then?

Edit: to drive the point home...

http://cid.oxfordjournals.org/content/51/2/197.full

"Live, attenuated Oka vaccines consist of a mixture of distinct VZV genotypes, which share several nucleotide substitutions that distinguish them from all wild-type strains of VZV (Table 1). Differences in strain content are observed among Oka vaccines produced by different manufacturers, and even among different batches from the same manufacturer (Table 1). This underlines the importance of genotyping VZV strains from vaccine-associated illnesses, including herpes zoster. "