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Immune Design Unveils G103 Subunit :( Vaccine Candidate


StayingUpbeat

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Immune design has finally released animal data on the structure and effectiveness of their G103 candidate.  Sadly, it's a gD based subunit vaccine that only shows about a 50% reduction in symptoms in animals.

http://www.sciencedirect.com/science/article/pii/S0264410X1501600X

This is the concept being developed in collaboration with Sanofi and supposedly started with the HSV-529 vaccine candidate.  Apparently a subunit was more effective when paired with their adjuvant.  

My guess is the real story is it was less risky from a financial and regulatory perspective.

What a shame.

 

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2 hours ago, StayingUpbeat said:

Immune design has finally released animal data on the structure and effectiveness of their G103 candidate.  Sadly, it's a gD based subunit vaccine that only shows about a 50% reduction in symptoms in animals.

http://www.sciencedirect.com/science/article/pii/S0264410X1501600X

This is the concept being developed in collaboration with Sanofi and supposedly started with the HSV-529 vaccine candidate.  Apparently a subunit was more effective when paired with their adjuvant.  

My guess is the real story is it was less risky from a financial and regulatory perspective.

What a shame.

 

SU....     Out of curiosity, do you know what the % reduction in animal testing was for: Genocea, Admedus, Halford, Draco, or any of the other current vaccines in development? 

Would you or anyone else know why no one seems able to get a higher % of treatment/reduced symptoms?  I know I have been critical of Gen-003's 50% reduction. Of course we want 100%, but I don't know the science behind it to understand the inability to achieve the goal. 

I really thought Immune Design along with Sanofi would have been able to do better :(

After all, the Hep C sufferers now have a 100 % cure and a few companies are delivering  competing drugs. 

Edited by herpes-sucks
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Sorry just to clarify, this is Immune Design's Trivalent Subunit Vaccine, and not Sanofi's Replication Defective Vaccine included... correct?

I can understand the Trivalent Subunit vaccine sucking... but not the replication defective one. 

On their site it states data from Human trials will be released the end of 2016, so how is this data relevant?

 

edit: I see its just the trivalent vaccine, which was expected anyway. No real news here.

Edited by lexyz22
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Lawrence Corey, MD

pushing his mediocre weak subunit vaccine

- wrapping it around the better stronger HSV 529 vaccine with a sticky tape.

Edited by Juggalo
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What's sad about this is that Sanofi will still have to pay a royalty payment to Immune Design given the agreement that was made. They brought in Immune Design in hopes that it would add value from a therapeutic standpoint. This is not good news for HSV-529. It won't help therapeutically. 

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42 minutes ago, HopefulOne2013 said:

What's sad about this is that Sanofi will still have to pay a royalty payment to Immune Design given the agreement that was made. They brought in Immune Design in hopes that it would add value from a therapeutic standpoint. This is not good news for HSV-529. It won't help therapeutically. 

We shouldnt be too disheartened. (unless herpes-sucks starts posting of course).

Sanofi's candidate is a strong one and we should wait until we hear results from their clinical trials first. (end of 2016 i believe). We all know subunit vaccines suck.

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1 hour ago, lexyz22 said:

We shouldnt be too disheartened. (unless herpes-sucks starts posting of course).

Sanofi's candidate is a strong one and we should wait until we hear results from their clinical trials first. (end of 2016 i believe). We all know subunit vaccines 

1 hour ago, lexyz22 said:

We shouldnt be too disheartened. (unless herpes-sucks starts posting of course).

Sanofi's candidate is a strong one and we should wait until we hear results from their clinical trials first. (end of 2016 i believe). We all know subunit vaccines suck.

We also know that Sanofi inked the deal with Immune Design to create an effective therapeutic vaccine. HSV-529 will be good from a prevention standpoint just like Halford's. It won't help people who already have it. Sorry.

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2 hours ago, lexyz22 said:

We shouldnt be too disheartened. (unless herpes-sucks starts posting of course).

Sanofi's candidate is a strong one and we should wait until we hear results from their clinical trials first. (end of 2016 i believe). We all know subunit vaccines suck.

@lexyz22

I am not not sure what your obsession or fascination is with stalking me and making this personal.

I'll just suggest you stop now....

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@HopefulOne2013Come on man.  I agree with you that people can't assume that halford's vaccine will work therapeutically but for that exact same reason you also can't say "it won't help people who don't have it."

We'll know one way or the other when the data is published, just like every other potential herpes vaccine (minus GEN-003), end of story. 

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2 minutes ago, throwawayday345 said:

@HopefulOne2013Come on man.  I agree with you that people can't assume that halford's vaccine will work therapeutically but for that exact same reason you also can't say "it won't help people who don't have it."

We'll know one way or the other when the data is published, just like every other potential herpes vaccine (minus GEN-003), end of story. 

What I mean is that it won't help people like some people project it will. There is a lot of hope for one researcher on this forum. I hope Halford nails it. He needs to get his vaccine in a trial. The science research for HSV is passing him by. He's been talking about his vaccine for 5 years now. I find it funny that some members on this board bash other companies but praise Halford. It's a double standard. 

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@StayingUpbeat How do you think this affects HSV-529?  If I recall correctly, Sanofi said they'd look at both vaccine candidates, and progress with the better one moving forward.  If HSV-529 performs well, I don't see how this affects it. 

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11 minutes ago, throwawayday345 said:

@StayingUpbeat How do you think this affects HSV-529?  If I recall correctly, Sanofi said they'd look at both vaccine candidates, and progress with the better one moving forward.  If HSV-529 performs well, I don't see how this affects it. 

Not trying to hijack the question but David Knipe who created HSV-529 gives a response on it in this video. The question is asked at 2:27.

http://m.youtube.com/watch?v=jnh8xwRfu-8

 

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55 minutes ago, throwawayday345 said:

@StayingUpbeat How do you think this affects HSV-529?  If I recall correctly, Sanofi said they'd look at both vaccine candidates, and progress with the better one moving forward.  If HSV-529 performs well, I don't see how this affects it. 

It also performed slightly better than a failed subunit vaccine and a DNA vaccine in preclinical trials. This was for animals with recurring disease. Immune Design's vaccine beat HSV-529. This is why I don't get excited for live vaccine, including Halford's.

 

 

 

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On 11/15/2015, 7:20:46, throwawayday345 said:

@StayingUpbeat How do you think this affects HSV-529?  If I recall correctly, Sanofi said they'd look at both vaccine candidates, and progress with the better one moving forward.  If HSV-529 performs well, I don't see how this affects it. 

In the context of forward progress the plan with Immune Design was to compare the efficacy of HSV-529 vs. Immune Design's subunit cocktail when Immune Design's GLA adjuvant was added. 

The end result of that investigation is what Immune Design (using Sanofi funding) was going to call G103.

I'm disappointed that Immune design decided to go with a subunit cocktail for G103 for two reasons:

  1. It means that there was likely no increase in efficacy to HSV-529 by adding  the GLA adjuvant
  2. A decrease in shedding on the order of 50% is likely about the maximum that can be expected by G103 (and probably all gD based subunit vaccines)

With that being said a new trial testing the efficacy of HSV-529 against Valtrex (co-sponsored by Sanofi and UW) just started: https://www.clinicaltrials.gov/ct2/show/NCT02571166?term=HSV&rank=1 so HSV-529 is by no means dead.  But G103 is not going to be the functional cure we were hoping for from what seemed like a very auspicious partnership.

---

Edited by StayingUpbeat
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Absolutely PATHETIC.

How many offing gd2 failed subunit vaccines do we need before we start developing live ones? Its an absolute disgrace. 

They could have solved the HSV problem decades ago, but they just keep playing games. Its all just one big joke. 

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4 minutes ago, Herbfresh said:

Absolutely PATHETIC.

How many offing gd2 failed subunit vaccines do we need before we start developing live ones? Its an absolute disgrace. 

They could have solved the HSV problem decades ago, but they just keep playing games. Its all just one big joke. 

@Herbfresh,

  All things considered I think there is still reason to be hopeful. From a development perspective therapeutics are marching along (albeit slowly) and several are on the horizon that could make a big difference.

Brincidofovir and Amenamevir come to mind with a lot of potential and the LSD-1 inhibitors will likely be the next drug tested against HSV.

From a live attenuated vaccine perspective HSV-529 is still being tested, Dr. Halford is starting a phase I trial, and the Albert Einstein vaccine is winding its way through pre-clinical testing. 

Immune design latching itself to a subunit concept is definitely disappointing but two steps forward, one step back, is the nature of commercial medical research.

 

---

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22 hours ago, StayingUpbeat said:

@Herbfresh,

  All things considered I think there is still reason to be hopeful. From a development perspective therapeutics are marching along (albeit slowly) and several are on the horizon that could make a big difference.

Brincidofovir and Amenamevir come to mind with a lot of potential and the LSD-1 inhibitors will likely be the next drug tested against HSV.

From a live attenuated vaccine perspective HSV-529 is still being tested, Dr. Halford is starting a phase I trial, and the Albert Einstein vaccine is winding its way through pre-clinical testing. 

Immune design latching itself to a subunit concept is definitely disappointing but two steps forward, one step back, is the nature of commercial medical research.

 

---

Imho, I have more hope in LSD-1 inhibitors than even Cullen and Bloom. To me it makes perfect sense to approach this route! Thanks for the link.

I also think amenamevir has a great shot at putting a dent into this epidemic.

Edited by dont quit!
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