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JustHanginginThere

Asp2151 Japan update help?

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JustHanginginThere

The end dates on the clinical trials show the Phase 3 trial should have ended mid this year. However, I can't see ASP2151 mentioned in Astellas's website under Pipleine Drugs. The latest news I found is below.

http://adisinsight.springer.com/drugs/800025919

Does anyone know the status? Can the savy investigators here write Mahuro (Japanese company conducting the trials or Astellas's) nd find out when trial results will be published and if they plan to commercialize the drug?

Although this will be in Japan it will be much more powerful than Valtrex as an inhibitor and will inhibit strains that are resistant to Valtrex (big deal). Hpi drugs have an entirely different mode of action. Basically we need this drug to come to market.

I hope it wasn't shelved due to toxicity.

 

 

 

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elnino

I contacted Astellas this week by email and they said all of their trials for ASP2151 have been either completed or terminated. They are no longer developing the drug. 

I don't know what Maruho is planning to do with it. 

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throwawayday345

@StayingUpbeat Any thoughts?  Wasn't the data supposed to be released sometime this month? 

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JustHanginginThere
15 hours ago, elnino said:

I contacted Astellas this week by email and they said all of their trials for ASP2151 have been either completed or terminated. They are no longer developing the drug. 

I don't know what Maruho is planning to do with it. 

Yes the trials in U.S. were terminated and I think trials in Japan are completed. We want to know if anyone is going to bring the drug for approval?

Edited by JustHanginginThere

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StayingUpbeat

Mum's been the word from Maruho. They have been holding and completing lots of trials but so far not released any data.  I really don't have a guess on this one.  Someone who speaks (and writes) Japanese should e-mail their media department and see what the story is.  ASP2151 is known as M5220 in their portfolio.

https://www.maruho.co.jp/english/contact/index.php?action_English_Contact_Lb=true

Edited by StayingUpbeat

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JustHanginginThere

Maruho wrote back. They stated that it takes time after trials are completed to post results.

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dont quit!
4 hours ago, JustHanginginThere said:

Maruho wrote back. They stated that it takes time after trials are completed to post results.

Very short answer. :(

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Voyager2

The pdf file

https://www.astellas.com/en/ir/library/pdf/2011_rd_en.pdf

seems to be from 2011 (!) and states

"We have decided to discontinue the development of asp2151 due to serious adverse events observed in a 28-day safety study."

But the link in the first post above indicates they completed a phase 3 trial on March 1, 2016. Maybe they decided to resume development of asp2151. Completing a phase 3 trial would be quite a milestone, no?

Something isn't adding up...

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@lw@ys
On ‎7‎/‎14‎/‎2016 at 2:10 AM, Voyager2 said:

The pdf file

https://www.astellas.com/en/ir/library/pdf/2011_rd_en.pdf

seems to be from 2011 (!) and states

"We have decided to discontinue the development of asp2151 due to serious adverse events observed in a 28-day safety study."

But the link in the first post above indicates they completed a phase 3 trial on March 1, 2016. Maybe they decided to resume development of asp2151. Completing a phase 3 trial would be quite a milestone, no?

Something isn't adding up...

They just haven't removed that link that is all.

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Voyager2
On 12/10/2015 at 4:19 AM, JustHanginginThere said:

Basically we need this drug to come to market.

I hope it wasn't shelved due to toxicity.

Since we've gotten nothing new for 30 years, we have to get this one. The only other thing in the near term is Genocea. Since the phase 3 trial for asp2151 ended March 1, we can be cautiously optimistic and hope for good news soon. Even if not perfect, if used in combination, it could be a game changer. 

Edited by Voyager2

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throwawaynyc
41 minutes ago, Voyager2 said:

Since we've gotten nothing new for 30 years, we have to get this one. The only other thing in the near term is Genocea. Since the phase 3 trial ended March 1, we can be cautiously optimistic and hope for good news soon. Even if not perfect, if used in combination, it could be a game changer. 

research halfords vaccine please, youre not up to date with whats available.

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Voyager2
2 hours ago, throwawaynyc said:

research halfords vaccine please, youre not up to date with whats available.

Fair enough - I'll include the work of both Bill Halford and Ian Fraser. All of these researchers are my heroes. Without them, we'd have no hope. 

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House of Herpesians

Hi, ALL (^^)

APS2151, currently renamed as Amenalief (I'm not sure of the spelling of the drug name...), is now at the final stage! 

Just wait and see (^^)

 

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moialbalushi
1 hour ago, House of Herpesians said:

Hi, ALL (^^)

APS2151, currently renamed as Amenalief (I'm not sure of the spelling of the drug name...), is now at the final stage! 

Just wait and see (^^)

 

Wowowowow. Really ?

1 hour ago, House of Herpesians said:

Hi, ALL (^^)

APS2151, currently renamed as Amenalief (I'm not sure of the spelling of the drug name...), is now at the final stage! 

Just wait and see (^^)

 

Wowowowow. Really ?

Do u have the link for it ? 

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House of Herpesians

To @moialbalushi

I found another link. The original link contains weird technical terms, so following link will be better to read. All information is written in Japanese. If you are not so good at the language, please ask somebody who can understand Japanese to help you read the page: 

https://www.mixonline.jp/Article/tabid/55/artid/57514/Default.aspx

Anyways, the final assessment meeting seems to be held around the end of this month. If the proposal is approved at the meeting, the ministry will quickly allow the company (Astellas) to start the production and sales of the drug. I am not so sure when the drug will be available, but I'm sure that we need doctor's prescription to get the drug. With Japanese national health insurance certificate, we can buy the drug with 70% of discount, but if you don't have the certificate, you will need to cover 100% of the expense, which means you need to pay A LOT for that.

If the drug is officially approved at the meeting, I will post the news here ASAP (^^)

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moialbalushi
4 hours ago, House of Herpesians said:

To @moialbalushi

I found another link. The original link contains weird technical terms, so following link will be better to read. All information is written in Japanese. If you are not so good at the language, please ask somebody who can understand Japanese to help you read the page: 

https://www.mixonline.jp/Article/tabid/55/artid/57514/Default.aspx

Anyways, the final assessment meeting seems to be held around the end of this month. If the proposal is approved at the meeting, the ministry will quickly allow the company (Astellas) to start the production and sales of the drug. I am not so sure when the drug will be available, but I'm sure that we need doctor's prescription to get the drug. With Japanese national health insurance certificate, we can buy the drug with 70% of discount, but if you don't have the certificate, you will need to cover 100% of the expense, which means you need to pay A LOT for that.

If the drug is officially approved at the meeting, I will post the news here ASAP (^^)

Thank you so much man. U really raised my hope !!

Edited by moialbalushi

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moialbalushi
36 minutes ago, JJ2017 said:

how well does the drug perform ? any data on this?

It is twice better than theravax in reducing shedding. Hope it can work with gen003 also. If both got approved it will be a miracle !!

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JJ2017

Amenalife tablet 200 mg (Amenamebiru, Maruho): Medicines containing new active ingredients targeting shingles as a target disease. << from the article when translated ..... are you sure this is for hsv?

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moialbalushi
11 minutes ago, JJ2017 said:

Amenalife tablet 200 mg (Amenamebiru, Maruho): Medicines containing new active ingredients targeting shingles as a target disease. << from the article when translated ..... are you sure this is for hsv?

From what I know. The antivirals used for hsv were used also for shingles before. Our freind above is Japanese so he knows more I guess.

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