Jump to content
World's Largest Herpes Support Group
JustHanginginThere

Asp2151 Japan update help?

Recommended Posts

dont quit!17
9 hours ago, thehopeisnear said:

So I'm a little confused - Amenalief was approved or amenavir was approved ?  

Maruho's lists the drugs as two different medications.  

Is there news coverage on this ?

According to @House of Herpesians. Amenamevir was renamed to Amenalief.

Share this post


Link to post
Share on other sites
Atrapasueños

Quisiera que cualquier cosa que está en las tuberías fuera eficaz pero maldicion solo hablan de años y años 

 

I wish anything in the pipes was effective but damn just talking about years and years

Share this post


Link to post
Share on other sites
JHenry

I understand----those younger have the "gift of time".   I was diagnosed nearly 30 years ago and will turn 65 in September.   In many ways, patience has serve me well--I Do believe it within striking distance and hope I'm here to see it.

Share this post


Link to post
Share on other sites
Atrapasueños

Tal vez lo veas así pero aún siguen diciendo que faltan años de investigación, o de ensayos con animales, 

Pero sinceramente te respeto como persona eres un ejemplo a seguir de como tratar esta enfermedad durante tantos años

@JHenry

You may see it this way but they still say that they are missing years of research, or animal testing,

But I sincerely respect you as a person you are an example to follow of how to treat this disease for so many years

Share this post


Link to post
Share on other sites
OFMDH
19 hours ago, Whyyyyy said:

@OhFuckMyDickHurts Can you shed some light on this please?

My understanding was that ASP2151 is for both Herpes Zoster (shingles ) and for us with Herpes Simplex 1/2. They have done their clinical trials with the FDA, so it would appear this could come to the US market (dont know when). 

In Phase 2 it tested different doses for shedding/time to heal etc vs valtrex and since then they completed  HSV Phase 3 /Zoster Phase 3  in 2016. When tested in people among the varying doses  (100mg to 200mg was the best) it was comparable to  1g Valtrex in efficacy in terms of OB reduction and shedding. [source]. It would appear Japan's regulators approved of it first for Herpes Zoster (antivirals have not been that good against it) and they approved a dose of 200mg.

They had to do another Phase 1 safety trial which just started last year. They had a wrench thrown into the works when urine samples showed supersaturation with the blood/plasma levels were appearing fine. Thus they had to totally revise the urine analysis methods/ collection and testing to retest and submit data for approval in December 2016.

Is that enough for the USA market? I don't know if they can stop there and use that data to get approval to now sell or it has to go further. Maybe up to a committee at the FDA?

Otherwise maybe the company's goal with ASP2151 is to get it approved and then go for niches that Valtrex and other antivirals are not servicing so well since its efficacy is comparable to Valtrex anyways. For instance I believe I've seen literature about using it to try and combat Postherpetic neuralgia a complication of Herpes Zoster and the company has since also filed this Clinical Trial  with Ciclosporin, a drug for organ transplantation. There appears to be a lot of future testing with this drug. 

TL:DR: For people in which valtrex or one of the analogues for it doesn't work, this drug ASP2151 aka Amenamevir appears to be a safe and effective alternative and may make it to market eventually in the USA (not sure when). It may also one day be used as part a potential combination therapy with a nucleoside analogue antiviral agent like Famvir/Valtrex, etc. requiring a smaller dose. 

Edited by OhFuckMyDickHurts

Share this post


Link to post
Share on other sites
Whyyyyy
3 hours ago, OhFuckMyDickHurts said:

My understanding was that ASP2151 is for both Herpes Zoster (shingles ) and for us with Herpes Simplex 1/2. They have done their clinical trials with the FDA, so it would appear this could come to the US market (dont know when). 

In Phase 2 it tested different doses for shedding/time to heal etc vs valtrex and since then they completed  HSV Phase 3 /Zoster Phase 3  in 2016. When tested in people among the varying doses  (100mg to 200mg was the best) it was comparable to  1g Valtrex in efficacy in terms of OB reduction and shedding. [source]. It would appear Japan's regulators approved of it first for Herpes Zoster (antivirals have not been that good against it) and they approved a dose of 200mg.

They had to do another Phase 1 safety trial which just started last year. They had a wrench thrown into the works when urine samples showed supersaturation with the blood/plasma levels were appearing fine. Thus they had to totally revise the urine analysis methods/ collection and testing to retest and submit data for approval in December 2016.

Is that enough for the USA market? I don't know if they can stop there and use that data to get approval to now sell or it has to go further. Maybe up to a committee at the FDA?

Otherwise maybe the company's goal with ASP2151 is to get it approved and then go for niches that Valtrex and other antivirals are not servicing so well since its efficacy is comparable to Valtrex anyways. For instance I believe I've seen literature about using it to try and combat Postherpetic neuralgia a complication of Herpes Zoster and the company has since also filed this Clinical Trial  with Ciclosporin, a drug for organ transplantation. There appears to be a lot of future testing with this drug. 

TL:DR: For people in which valtrex or one of the analogues for it doesn't work, this drug ASP2151 aka Amenamevir appears to be a safe and effective alternative and may make it to market eventually in the USA (not sure when). It may also one day be used as part a potential combination therapy with a nucleoside analogue antiviral agent like Famvir/Valtrex, etc. requiring a smaller dose. 

Thank you so much! In your honest opinion do you think this is better than Valtrex? I know you said it's comparable...

Edited by Whyyyyy

Share this post


Link to post
Share on other sites
MoniqueLow

Thank you, @OhFuckMyDickHurts.

It looks it has a bit better efficiency in smaller doses than valtrex. The shedding seems to be worse with it though (if I have understood right). 

In my very layman understanding, this drug doesn't need thymidine kinases to activate which was problem with hsv resistant strains, so this may be the biggest advantage? 

I hope it will be approved globally as a valtrex alternative. Pritelivir may follow (as I remember they had very good results with asymptomatic shedding).

Still, with my lack of knowledge, I am wondering why it is such difficult to kill the virus instead of just preventing it's replication. The drugs can recognize it in cell, right? Is there any chance to develop drug which can kill it or disable replicating forever? Vaccines are good approach for sure (if I can dare to judge), but relying on person's immune system can be tricky as we see on comments from participants of clinical trials of various vaccines.

Thanks.

Share this post


Link to post
Share on other sites
MoniqueLow

In my very naive imagination I wish there's something for viruses as there are antibiotics for bacterias. What I have read ( just on my"science level"), the problem with viruses compare to bacterias is that drug cannot find it (as they are in cells and have similar proteins as host cell) and they mutate. Then what I understood, AVs can find virus in cell and hsv doesn't mutate as much and more over we know where it sleeps. 

I guess the answer is gene editing, but couldn't it be just chemical drug - like 14 days pill and it's done?

I'm sorry if my lack of knowledge has offended anyone and that I hijack this thread to ask maybe very useless questions. Thanks.

Share this post


Link to post
Share on other sites
Dan S H
2 hours ago, MoniqueLow said:

In my very naive imagination I wish there's something for viruses as there are antibiotics for bacterias. What I have read ( just on my"science level"), the problem with viruses compare to bacterias is that drug cannot find it (as they are in cells and have similar proteins as host cell) and they mutate. Then what I understood, AVs can find virus in cell and hsv doesn't mutate as much and more over we know where it sleeps. 

I guess the answer is gene editing, but couldn't it be just chemical drug - like 14 days pill and it's done?

I'm sorry if my lack of knowledge has offended anyone and that I hijack this thread to ask maybe very useless questions. Thanks.

Hey i wish they could find a cure like they did for her c. Even a functional cure.  

Share this post


Link to post
Share on other sites
Whyyyyy
3 minutes ago, Dan S H said:

Hey i wish they could find a cure like they did for her c. Even a functional cure.  

Me too! This sucks :(

Share this post


Link to post
Share on other sites
Atrapasueños

Todos los sectores tienen la culpa de que no exista una cura, el sector médico porque sólo lo ve como un problema de la piel, en el sector de investigación prefieren otras enfermedades como cáncer, vih hepatitis, y enfermedades genéticas, en el sector gobierno prefieren dar presupuesto a investigadores que se centran en las enfermedades mortales y en la comunidad H la mayoría no se apoya para que nos escuchen prefieren quedarse en silenció

@MoniqueLow

All sectors are to blame that there is no cure, the medical sector because they only see it as a skin problem, in the research sector prefer other diseases such as cancer, hepatitis hiv, and genetic diseases, in the government sector prefer Give a budget to researchers who focus on deadly diseases and community H most do not support to hear us prefer to remain silent

Share this post


Link to post
Share on other sites
Lauren401
On 5/20/2017 at 5:52 PM, MoniqueLow said:

Thank you very much. If it's good, I may go to Japan for it. I wanted to visit it anyway :-)

@MoniqueLow I'll go with you! We can share an AirBnb! hahaha. :)

Share this post


Link to post
Share on other sites
Whyyyyy
1 hour ago, Lauren401 said:

@MoniqueLow I'll go with you! We can share an AirBnb! hahaha. :)

I'm in too! #girltrip

Share this post


Link to post
Share on other sites
Dan S H
2 hours ago, Whyyyyy said:

I'm in too! #girltrip

How many pills could we carry with us?! ;-)

Share this post


Link to post
Share on other sites
oneday
8 hours ago, Whyyyyy said:

I'm in too! #girltrip

Me three!! ;)

Share this post


Link to post
Share on other sites
StayingPositive17

So how long do we wait until its available??

Share this post


Link to post
Share on other sites
medicalanonymo
12 hours ago, Whyyyyy said:

I'm in too! #girltrip

I am in too, Valtrex does not work for me .. I'm lesbian during the trip until return.  When tho?

Edited by medicalanonymo

Share this post


Link to post
Share on other sites
Dan S H
11 hours ago, takeoff-signet-pretzel said:

Could you provide a source for this, please?

I thought the decrease in shedding was impressive?

Share this post


Link to post
Share on other sites
moialbalushi
2 hours ago, Dan S H said:

I thought the decrease in shedding was impressive?

Yeah me too. 

Share this post


Link to post
Share on other sites
Whyyyyy
35 minutes ago, moialbalushi said:

Yeah me too. 

Yeah I thought I read somewhere that it was too...

Share this post


Link to post
Share on other sites
hurryup
On 6/1/2017 at 10:27 AM, Lauren401 said:

@MoniqueLow I'll go with you! We can share an AirBnb! hahaha. :)

Makes sense, Japan is where I picked up this wonderful gift. Would be nice to fly back out there and drop it off.

Share this post


Link to post
Share on other sites
cantdoit
On 6/2/2017 at 4:09 PM, Dan S H said:

I thought the decrease in shedding was impressive?

Where can I find the shedding data or can you tell me?

Share this post


Link to post
Share on other sites
Dan S H
1 hour ago, cantdoit said:

Where can I find the shedding data or can you tell me?

I heard 95% reduction.  But i don't have the link for it

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • The Hive is Thriving!

    • Total Topics
      69,296
    • Total Posts
      466,214
  • Posts

    • that1youngguy
      hello all, update... so the white ulcer inside started around january 4... and today it is still there... no burning while i pee, just a constant mild irritation feel, no other symptoms i went back to get retested 2/12 so 2.5 months after exposure... including HSV, HIV, gon, chlam, everything came back negative... the doctor thinks it's some form of chlamydia, he gave my doxy for 10 days is it too soon to tell if i have HSV? is it possible to have an ulcer inside the urethra and be fungal or bacterial?
    • MikeHerp
      Probably not many.  I'm going to change my twitter symbol to the copper ribbon at least.  
    • nope1234
      okay! I guess I will just start at the basic dosage of vitamin C and go up every week little ? I take 1500 mg of super lysine like the bottle says and it still gives me gas and diarrhea. hoping it will pass if not I'll drop down to 2 a day! I really appreciate the advice! i know we would all.do ANYTNING to not have OB  at the moment idc about stigmas od boyfriends or dating or sex....I just care about FEELING healthy in my own skin. this is my one and only life 
    • Lulupazoola
      That sounds like a good place to begin.  The lysine worked really well for me for about a year and a half.  Then things got steadily worse for me and nothing worked until vitamin C.  My immune system is not that great even tho i take care of myself, so u may have good luck if u have a decent one.  With the vitamin c, u must 1) take it at intervals throughout the day, not all at once 2) dont increase the amount u r taking too fast 3) it will give u gas at higher doses and even diarrhea if u go crazy with it. These r signs to lower your dose!  If u can just control your OB's with vitamin c and lysine or anything else, maybe a cure will finally become available.  
    • nope1234
      any updates? worth the pricetag?  
×

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.