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Halford continues proving mice vaccination effectiveness

Juggalo

By Juggalo
in Herpes Cure Research

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Juggalo Established Member

Juggalo

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145228

Halford Paper, recent. The live vaccine from Halford makes many mice survive extreme HSV2 chalenge, so for protection purposes it is very very effective (nearly 100% in healthy vaccinatedmice). Too bad it was not tested deeply for therapeutic purposes.

Let's hope that Halford and his company Rational Vaccines enters the game soon, while in the meanwhile Admedus, Genocea and Sanofi are pushing midway through cinical trials.

Edited by Juggalo
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Herbfresh Honeycomb Member

Herbfresh

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How come they NEVER test for therapeutic effect in mice? Even when they claim the main aim of it is therapeutic like with Admedus, they still don't test for therapeutic effect on mice!

 

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Herbfresh Honeycomb Member

Herbfresh

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16 hours ago, VVK said:

Halford's vaccine is also meant to be preventative, not therapeutic.

Its not, not meant to be therapeutic. But yea, preventative is the main aim.

He also says its certainly more likely to be therapeutic than the other vaccines. And he said its likely it has a strong therapeutic effect but he cannot be sure either way until it is tested. 

But if other vaccines have small therapeutic effects. Why wouldn't a halford vaccine that is meant to elicit a response thousands of times more powerful also have a therapeutic effect? You'd expect it would also be therapeutic only much more so.

 

 

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lexyz22 Established Member

lexyz22

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1 hour ago, Herbfresh said:

Its not, not meant to be therapeutic. But yea, preventative is the main aim.

He also says its certainly more likely to be therapeutic than the other vaccines. And he said its likely it has a strong therapeutic effect but he cannot be sure either way until it is tested. 

But if other vaccines have small therapeutic effects. Why wouldn't a halford vaccine that is meant to elicit a response thousands of times more powerful also have a therapeutic effect? You'd expect it would also be therapeutic only much more so.

 

 

It stands to reason that Halford's vaccine would have a therapeutic effect. 

The body would be injected with his 0DLNS virus (or whatever its called), which exposes the immune system to a larger proportion of the virus than Subunits, thus allowing immune surveillance to recognise the initial infection much better. (this is a wholly simplified version of what it would do, but basically it would improve your immune surveillance, leading to less breakouts and potentially less viral shedding, who knows, only time will tell),

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vzhe Established Member

vzhe

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Yeah, I like that Dr. Halford is careful in his statements.. but really it's incredibly unlikely that all the very effective antibodies that his vaccine creates wouldn't be super helpful for keeping the virus under control... Looking forward to the trials.

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Sanguine108 Platinum Support Member

Sanguine108

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Dr. Halford is no dummy. He knows these therapeutic vaccines are a waste.  I commend him to working on prevention of further spread of this virus and I hope it works.  If it works therapeutically, great.... But I think it'll be short-lived relief at a premium cost.

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VVK Platinum Support Member

VVK

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The therapeutic results of a live attenuated vaccine for herpes exists in the bodies of every single person whose immune system is functioning properly and has successfully adapted to HSV.

i.e. little to no symptoms, but with some shedding

Fighting the virus from within is harder than stopping the virus from coming into the body in the first place.

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dont quit! Established Member

dont quit!

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If Genocea hit a 58% decrease in shedding for 6 months. I don't see why Halfords live vaccine wouldn't be able to hit a solid 70% decrease in shedding for a year or possibly two. For 2016 we have Acam 529 results at the end of calendar year and a possible Halford trial with results. We can only hope that these trials change the way research is done for this condition.

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tom343 Established Member

tom343

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Meh. Genocea will improve. I think Halford will be great for ppl who haven't been infected with herpes but as a therapeutic vaccine for basically all of us infected atm, I don't hold much hope. I think Halford if he can produce will be a great thing for partners of HSV carriers. 

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lexyz22 Established Member

lexyz22

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There have been recent studies from other scientists that have shown positive effects of live attenuated viruses for therapeutic purposes. Seriously just look on Google Scholar. 

Halford's vaccine WILL have some form of Therapeutic effect, this is anyone's guess, It could be 10% or it could be 90% reduction in symptoms and shedding, honestly people jump to conclusions WAYYYYYYYYYY before any quantifiable research has been done. All I do know is that there is a small precedent there already with other people who have found therapeutic effects from live attenuated viruses in people already infected with that virus strain.

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dont quit! Established Member

dont quit!

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If people take time and read his blog he explains why he believes his vaccine has a chance to work therapeutically i.e. Pictures of guinea pigs with or without outbreaks. Fluorescent pics of antibody response in animal models. Explanations of huge amount of humoral response. Its at the very least worth testing. Meh my ass.

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tom343 Established Member

tom343

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I think everyone on here hopes it will do that but it's miles behind atm on the therapeutic side compared to a genocea or admedus who are in actual ppl trials. But these therapeutic vaccines are not preventative and obviously Halford if successful can thus eliminate herpes. 

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Herbfresh Honeycomb Member

Herbfresh

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Yup, Halford seems legit. But his work is not going to bear fruit anytime soon. 10 years? 20 years? These amounts of times, and none of us will be that young. It will be too late by then, for it to save our lives. 

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lexyz22 Established Member

lexyz22

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3 hours ago, Herbfresh said:

Yup, Halford seems legit. But his work is not going to bear fruit anytime soon. 10 years? 20 years? These amounts of times, and none of us will be that young. It will be too late by then, for it to save our lives. 

It will be sooner than you think.

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