Classification of curative approaches

[Cure Researcher]

There are different attempts to tackle treatment/functional cure approaches. I think we should come up with an NGO/ITO type of website that can put together and classify and inform and evaluate all meaningful researches, technologies, legal, governmental regulation, etc. information so that we can inform anyone, from any background and organization, should be able to access quality data to find better treatment and cure for herpes virus infections.

Below is my initial brain-storming attempt of this classification.

When I have time, I am going to refine and classify all of them and create a system where professional researchers, investors, companies, and different countries and governments for fast-tracking and better clinical trial countries/options, discontinued yet promising candidates. And send it to all media outlets as well as researchers and individuals such as mark Zuckerberg and Bill gates and world leaders and WHO, on a regular basis, and somehow better solution will come out eventually I hope. We could make videos to raise awareness about the damage of the virus as well as additional HIV/syphilis/hepatitis risks caused by herpes lesions and immune cells. And we could also inform symposiums and forums.

In order for herpes to be genuinely and functionally cured, such increased health risks to HIV and other viruses via immune cells concentration should be reversed as well as outbreaks should be better suppressed.

Following areas has to come into orchestration to find better solutions for herpes treatment and cure.

Neurology

Virology

Immunology

Dermatology

Neural Immunity

Chemistry

Biology

Nano-technology

Biotech

Clinical trial regulations

Government/politics

Journalism

Business

Drug development

Supplements

Following is organization of cutting edge HSV curative/therapeutic approaches observed on the Internet so far. Thank you very much for your all your hard work in searching for the cure and providing afflicted patients hope. I will continue find better ways to organize them further/better/in-depth to inspire focused knowledge sharing(including all relevant meaningful research data, and archives), to establish meaningful connections and to find, present and connect to ideal funding sources from now on.

 

1. latent viral genome cleavage

CRISPR/CAS9 or TALENs or HE etc + guide rna protein sequence + viral vector

 

Pros: If successful, viral latency 

Risk: Off-targeting and mutation, guiding protein sequence difference amongst different sub-strains might render it dysfunctional.

Challenges: Successful administration, vector and delivery without adverse clinical problem/toxicity. Prevention of off-target incidents.

Solutions: More advanced forms of off-target proof CAS versions. In Korea, there exists a company called ToolGen which has their own error-proof version and recently MIT and more people are coming up constantly with safer versions of CRISPR/CAS9 technology.

Tailoring of guide RNA of target viral plasmid via PCR, or individual, country and strain specific genetic specimens.

 

2. flushing out/awakening of latent virus

viral latency abrogation strategy (inducing lysis+antiviral)

Anti LAT enzyme + Acyclovir/antiviral administration ( + viral vector to deliver it directly into cells )

 

3. Viral detection followed by cellular Apoptosis induction

ADACO: antigen-domain specificity enabled caspase ogliomerizer

(more specific than Draco, less riskier)

DRACO: dsRNA caspase ogliomerizer

Pros: Simpler than no.1 method

Risk: Unexpected cellular apoptosis may result in unexpected medical severity.

 

4. Vaccines

Live-attenuated antigen rich vaccines

DNA subunit vaccines

Etc.

 

Using VZV vaccines to reduce HSV symptoms (French study)

 

5. Epigenetic treatment / better anti-viral

 

LSD-1 inhibitor

Helicase-premise Inhibitor (pritelivir)

 

Chromatin

 

Stem cell, immunomodulation, designer enzymes, designer protein etc. to interrupt viral latency in any affected ganglion and induce infected cell lysis. Different in-vivo monitoring, scanning, visualization methods and technologies. More varied/advanced forms of or similar to CRISPR/CAS9. Et cetera

 

 

6. Selective combination of all of the above. / Other category ...

 

Partial removal of sensory/peripheral neurons.

[Achesve]

Bump