Pritelivir (AIC316) is not dead

[elnino]

Aicuris finally responded to one of my emails from a month ago with the following (bold emphasis mine):

Many thanks for your interest in pritelivir (AIC316) and our herpes program. Presently, there are no clinical trials ongoing. Please find further information on our homepage (http://www.aicuris.com).  Since pritelivir is still under development, we are unable to disclose any additional information at the moment.

Thank you very much for your understanding.

 

 

[Herbfresh]

Sorry but that sounds extremely dead to me. 

No ongoing clinical trials with phase 3 trails over like what 2-3 years ago? Look, this was killed for the same reason they have been killing promising vaccine candidates in favour of scams like Ademdus. The point is not to cure us. 

And who will care? It's HSV. The world will be 100% okay with letting HSV stay exactly as it is, and Pharma obviously would love to sell us their crappy anti virals that need to be taken everyday for the rest of time. 

[Sanguine108]

I think they're just doing long-term toxiology studies.  There were red flags and they're seeing how gnarly, if it is that gnarly, on an individuals organs, physiology and whatnot.

[Herbfresh]

You think so? Then what are clinical trials for? Why don't all meds go through long term toxicology studies? Doesn't seem like that would be the case. 

And weren't they forced to test this on monkey models with over a hundred times the recommended dose? That kinda tells you all you need to know. FDA at the behest of Pharma killed it. This drug finished its clinical trials a long time ago now.

Isn't there a similar Japanese pill?  

Edited January 13, 2016 by Herbfresh

[JarJar69]

It's really unfortunate, but this totally sounds axed to me. Be it legitimate concerns over the safety of the drug or pharma being pharma (I think it's actually the latter) this thing is so dead in the water. That being said all we can do is hope that these vaccines coming out work. Although it is historic I'm not that impressed with Genocea's results as it works just as well as current antivirals (when it comes to viral shedding). Hopefully Admedus turns out a game changer that is better than what Genocea has produced. Until then it's just seems like it's the same thing over and over again.  A company has a promising great idea to combat this virus only to be shutdown. 

[Penumbra]

Maybe it's just me but Genocea vaccine that give the same result as taking daily antiviral seems like a pretty big deal to me.  Taking daily oral medication have much more significant side effects on your system that having a year'y injection, as far as I know at least!

[tom343]

1 hour ago, Penumbra said:

Maybe it's just me but Genocea vaccine that give the same result as taking daily antiviral seems like a pretty big deal to me.  Taking daily oral medication have much more significant side effects on your system that having a year'y injection, as far as I know at least!

Yeah exactly. 

I also agree with elnino. It sounds as though the drug is being refined for possible trials in the future. 

[JarJar69]

1 hour ago, Penumbra said:

Maybe it's just me but Genocea vaccine that give the same result as taking daily antiviral seems like a pretty big deal to me.  Taking daily oral medication have much more significant side effects on your system that having a year'y injection, as far as I know at least!

Sorry I may have come across as dismissive of Genocea's work, but that was not my intention. Of course taking a vaccine that allows your body to better fight against this infection naturally is a big deal. My issue is strictly having to do with the viral shedding data they released. My biggest concern of this condition is unknowingly infecting someone when I am shedding not so much the outbreaks as nobody really knows when they are shedding or not. With only a 58% reduction in shedding (which again is historic and a monumental achievement)  there is still a chance that you could infect your partner. I'm sure Genocea will improve the vaccine but for now it's all I have to go on. 

[Herbfresh]

Pharma releases all sorts of meds all the time as long as they go through the safety trials and all 3 phases safely. They have FREQUENTLY released drugs with clinical data proving it to be less effective or less safe than existing drugs. Pretty standard stuff. 

We know that AIC316 didn't have problems during these clinical trials. The problems only emerged when the FDA ordered extra tests. So lets see, some drugs like ones for heart conditions and hypertension, they have allowed released even when it is inferior to existing drugs, and when AIC316 comes along, with no such problems they order extra tests to find such problems?

They don't want this out. They don't want a live vaccine. They don't want it cured. Why in gods name would they? They can fuck us off all they want, its not HIV or cancer, there is zero political blow back. Any articles plastered over the New York Times about pharma HSV corruption? Of course not. Never will be. We are their playthings. They will keep us on their crappy and ancient anti virals for decades more. A live vaccine could've been made over 20 years ago, and none of would've ever had reason to come to here. 

Edited January 13, 2016 by Herbfresh

[Constant Diplomat]

- Valtrex and Famvir are available generically. Do the companies who initially owned and sold these drugs still profit from the generic versions?

 

- 'Pharma' is a bunch of different companies- some, maybe a lot, are probably owned bu the same evil corporation(s). Does this lend an idea as to who a pharama company is and what their goals are? Money is the goal, but if there is competition, then there is a chance. If 'Pharma' is keeping something like Pritelivir down, then who is 'Pharma'? Is Pharma the company who own Valtrex? It would stand to reason...

[Sanguine108]

5 hours ago, Herbfresh said:

drugs like ones for heart conditions and hypertension

So these people are usually much older and I think the concern about them reproducing is not there.

The herpes population is pretty vast.  People as young as 15 get herpes.   So before they put out a drug that potentially screws another entire generation/population then we're talking about long-term reproductive studies.

I would like to believe that it's completely safe and it's a big conspiracy.  But the world has already put drugs on the market that cause serious birth defects that continue through the germ (generation to generation) line.

Here we have a drug that screws with the viral DNA... I don't think that's all it's screwing with. That's all that we can tell it screws with.   So doing this long-term reproductive studies is essential.  Unfortunately, they take a lot of time.

But if it's corruption then it's corruption.

Edited January 14, 2016 by Sanguine108

[elnino]

Sure, there are no clinical trials currently, but I disagree with those who say it's dead. If so, why would Aicuris tell me it's still in development? They could have just said it's dead forever. Furthermore, another poster (I don't remember the name) had personally spoken with Anna Wald recently and she told him the drug is being tweaked for future trials. She was involved in the drug development and early trials so she is certainly in the know. 

Regarding corruption allegations...I don't doubt that it happens, but don't you think Aicuris also has an army of lawyers and scientists to fight for their side also? They wouldn't just give up and throw this drug away after investing many millions of dollars to get through Phase II trials. As much as GSK would fight to thwart this drug, Aicuris would fight to see it succeed. 

And to those who accuse the FDA of requiring extra animal tests which are not required for other drugs...how do you know? Are you personally involved in drug development? Can you provide some backup to this claim? I would sincerely be interested in reading about the process if you can share something. 

And as I have posted previously, this drug is being advertised on medical licensing websites as available for licensing and Phase III trials. 

I can't say with certainty what is happening behind the scenes, but there is more evidence pointing to this drug being still in development than not. 

 

[JustHanginginThere]

On ‎1‎/‎12‎/‎2016 at 6:27 PM, elnino said:

Aicuris finally responded to one of my emails from a month ago with the following (bold emphasis mine):

Many thanks for your interest in pritelivir (AIC316) and our herpes program. Presently, there are no clinical trials ongoing. Please find further information on our homepage (http://www.aicuris.com).  Since pritelivir is still under development, we are unable to disclose any additional information at the moment.

 

Thank you very much for your understanding.

 

 

I wrote and got the exact same email.  I asked for them to clarify whether they meant the topical or the oral is still under development.  They would not say.  I also did a lot of digging--no one knows.

[prigger]

Received this today in my email. Not really sure what it means, what do you think?

 

This is the email snippet:

 

AvaRx Content Team <Support@torreyainsights.com>	6:32 AM (43 minutes ago)
to me

 

 

 

 

 

Hello,

The opportunity you are tracking, Pritelivir (AIC-316) has been recently updated.


Subscibe to premium account to view the opportunity profile.

Sincerely,

The AvaRx Content Team
Content@avarx.com
+1 212-257-6040

[elnino]

It looks like it was removed from that site. That could mean it sold or was killed off. It's still on another licensing website, so who knows?

[optimistic2509]

All check liveherpesvaccine.com & if you like you can donate a small amount , This way we can bring the cure very soon.

[elnino]

4 hours ago, optimistic2509 said:

All check liveherpesvaccine.com & if you like you can donate a small amount , This way we can bring the cure very soon.

Hanford is not a cure. It's a prophylactic. There are plenty of other threads to discuss that in. THis thread was about pritelivir. 

[JustHanginginThere]

The company confirmed they are pursuing a topical.  I would consider the oral version dead-it is not available for license and the status has not changed (aka dead). 

Edited January 31, 2016 by JustHanginginThere

[optimistic2509]

There is a phase 3 going on for ASP2151 in japan but nit sure when they will confirm the results.

[Sillybrain2]

I got this reply from Maruho the ther day. It doesn't say much and doesn't clarify anything I had asked in my original message to them  I was hoping they would at least mention if they have applied for approval. I would assume phase 3 has been completed.

Thank you for your E-mail.
I'm sorry that I didn't reply to you sooner.
The trial results will be shared on the databases within 1 year after the approval/launch according to the rules.
On top of that, they might be disclosed in other ways earlier compared to the databases depending on the situation. But nothing has been decided in regard to when and how to be revealed to the public at the moment. Thank you for your understanding.

[tom343]

http://www.aicuris.com/90/Research-Development/Virology/Projects/HSV-Pritelivir-AIC316-.htm

http://labiotech.eu/aicuris-10th-year-german-biotech-with-ceo/

Looks like this is very much alive. They are looking for partners atm. 

[Constant Diplomat]

https://uk.finance.yahoo.com/news/aicuris-initiates-clinical-development-topical-070001849.html

Apologies if this has been posted already. It's from April 2016.

[optimistic2509]

is there any further information you got for aic 316

[Felix12]

Read an article about pritelivir in the news today. It seems to beat acyclovir in reducing shedding and minimizing outbreaks. Very promising!

[Felix12]

http://www.fredhutch.org/en/news/center-news/2016/12/experimental-herpes-drug-pritelivir-more-effective-than-standard-treatment.html