Looking for help....

[Broken_14]

Myself and a few other people are looking for a group of individulas that are wanting to push for a cure now and not in 10+ years from now. I don't see a cure coming anytime soon, unless we go after it ourselves. 

We need: Biotech Scientist, Doctors, Labs, etc. 

 

[fixme1]

Seen as moneys always the route of everything, who has the money?

[Broken_14]

We will raise the money or people will pay for their own seat to get the drug. 

[mcmich]

I was kind of thinking the same thing. While Aurx wants to raise 10 million to run phase 3 trials I think it could be done for much less. I was researching contract vaccine manufacturing companies and it seems you can make smaller lots (for test and research purposes). 

Personally would like to try the Aurx or the albert Einstein College vaccine. While not a cure, they would greatly reduce symptoms and possibly shedding (at least Aurx, the other vaccine has only been in animal models but seems to work well). 

This would be the first step and if the vaccine from albert Einstein can stop people from becoming infected, we could all live a normal life. Obviously a cure would be the final goal. Herpes infections cause many other problems later in life.......

[vzhe]

Broken: Shoot me a message! I've got money and worked in biotech.

[vzhe]

@mcmich: Despite the publicity efforts by those two other vaccines, I believe Dr. Halford is actually your best bet in the vaccine space. They've recently raised considerable money and have a full team working on this.

[Macuser]

3 hours ago, vzhe said:

Broken: Shoot me a message! I've got money and worked in biotech.

I like this message:

I have got the money!!!

so cool.haha

[blistering love]

What happened to DRACO? Did Dr Rider  just up and run away with the money?

[VVK]

$100k is not very much in the realm of academic research - it will probably cover lab rent costs for a few years

[mcmich]

Hi vzhe

What I was thinking was ordering samples of these vaccines for "research" purposes. I know we cannot just buy them and start administering to everyone, but why not buy these vaccines for ourselves and do the studies using ourselves as test subjects.  The Albert Einstein vaccine seems extremely promising. It protected 100 percent against infection. No other vaccine has shown that promise. Why not use it to see how well it works as a therapeutic vaccine.

http://blogs.einstein.yu.edu/developing-a-herpes-vaccine-a-new-approach/

"When we tested the vaccine in immuodeficient mice, it proved completely safe: The vaccine caused no signs of disease and no virus was ever detected in nervous tissue—the site where latent HSV lurks. To test the vaccine’s effectiveness, we gave it to mice and then challenged them with high doses of HSV-2 or HSV-1 administered intravaginally or through the skin. The mice were completely protected from infection, and, again, no latent virus could be detected in nervous tissue.

 

No other HSV vaccine candidate had ever completely prevented HSV viruses from becoming latent.

- See more at: http://blogs.einstein.yu.edu/developing-a-herpes-vaccine-a-new-approach/#sthash.ntESptWm.dpuf"

[vzhe]

Your general idea sounds promising to me, but I think it's important to dig down into what vaccines actually make the most sense.

The Einstein College vaccine actually targets a vital protein (gD) which makes it a far worse vaccine candidate for a long-term prophylactic (that is, not just protection for 6 months but for years, which is necessary for a prophylactic, and highly desirable for a therapeutic unless you want boosters every 6 months). ICP0 on the other hand regulates latency and allows for a wide range of attenuation properties.

Halford hasn't just made one vaccine but a set of different ICP0 zero mutants, and then systematically tested which one has the right safety, efficacy, and latency to provide for a long-term immune response. Einstein is where Halford was a decade ago in animal trials, and sadly the protein they picked does not allow for the kind of finetuning that would be needed to turn this into a real vaccine.

So if you're gonna do this.. best to do it with Halford's vaccine.

[Sillybrain2]

Hey @vzhe do Halford's vaccines apply to type 1 as well or just type 2?

[vzhe]

@Sillybrain2 Halford made vaccines for both HSV-2 and HSV-1, but right now is focusing on HSV-2. If the HSV-2 one gets to market, the HSV-1 will get to market too, but maybe a bit later.

[fixme1]

Seems to be the same conversations in circles here. Anyone able to get any of these people to post on here? Maby when they see how many people are willing to help out it might help drive research. 

[JustHanginginThere]

I swear to WHATEVER if you people Hijack a cure thread once more with your stupid Halford crap well.....you get my point.

Keep Vaccine talk in Vaccines.  Vaccines take a LONG time to develop and test. 

The majority of people willing to help aren't sitting around on Honeycomb and spending all their time praying to their Halford God.  If people on here have PHDs, work in Biotech, have web development/marketing skills, or interested in participating in funding such a project feel free to speak up on here.

 

[Sillybrain2]

And it has to be something that is going to target both type 1 and 2. 

[JustHanginginThere]

Great point Sillybrain it is important to focus on both HSV-1 and HSV-2.

[Broken_14]

Once again, Halford's vaccine isn't going to be a cure. It's only for those who aren't infected. This is about a TRUE CURE. 

[StayingUpbeat]

On 1/18/2016 at 6:51 PM, Broken_14 said:

Once again, Halford's vaccine isn't going to be a cure. It's only for those who aren't infected. This is about a TRUE CURE. 

All of the vaccine's (including Dr. Halford's) are being tested first as a therapeutic treatment.  The concept is that increasing the immune response to HSV via a vaccine has the potential to reduce the frequency and severity of outbreaks.  In clinical trials of Genocea's vaccine it brought symptoms (for about a year) down to the order of taking daily antivirals. 

In an ideal situation there is the potential for one of these vaccines to reduce the burden of HSV to that of the VZV (a.k.a. chickenpox/shingles) in which the virus is latently present but cannot, or is very rarely able to, overcome the immune system and cause an outbreak.

This concept is called a "functional cure" and should be a part of any rational discussion of cure research.

 

Edited January 20, 2016 by StayingUpbeat

[VVK]

Are you all looking at a particular approach to a cure or is this just a general cure "human resources" thread? Because biotech scientists, doctors, labs, etc. are all quite specialized in what they do and what they are for.

[Broken_14]

We have a couple of different ideas about a cure but this is forum is looking for people to help that have experience or know someone who does as far as working in labs and stuff.