Jump to content

New Study Shows Type Specific IgG Blood Test is FALSE NEGATIVE 12-30% of the time


StayingUpbeat

Recommended Posts

Published in the most recent edition of the journal Sexually Transmitted Infections:

False-negative type-specific glycoprotein G antibody responses in STI clinic patients with recurrent HSV-1 or HSV-2 DNA positive genital herpes
http://sti.bmj.com/content/early/2016/01/11/sextrans-2015-052213.abstract

Quote

 

Conclusions: Commercial type-specific gG HSV-1 or HSV-2 antibody assays were false negative in 12–30% of patients with recurrent HSV-1 or HSV-2 DNA positive genital lesions. The clinical and epidemiological use of type-specific HSV serology can be hampered by false-negative results, especially if based on a single test.

 

Thank god these ridiculously inaccurate type specific IgG blood tests are finally starting to get some highly needed scrutiny.

Edited by StayingUpbeat
Link to comment
Share on other sites

Hi guys I am positive for hsv 1 and I tested negative for hsv 2 4.5 months after sex and my doctor said I can definitely move on and believe I don't have hsv 2 based on my hsv 2 result. What should I do? I have bad anxiety and drove six hours to the nearest city that did the IGG blood test. I also had to pay like almost 200 bucks for this test. I can't afford to drive again and now I wonder if I can even trust my result? What should I do? I waited almost five months to test and was confident in my hsv 2 result. 

Link to comment
Share on other sites

Anyone? I did the IGG almost five months after sex with someone (not sure if they had herps for sure) and it was negative for 2. Positive for hsv 1. I can't afford to drive or retest. My doctor told me 3 to 4 months could be conclusive. Now my anxiety is really bad and I wonder if it could be false neg. Terri warren told me 98 percent accurate in my time frame and dr hands field said the test isn't perfect but it could be relied on after four months. 

Link to comment
Share on other sites

9 hours ago, fixme1 said:

I know people get false negatives . I definatly have done recently

do you have 1 or 2? How long after exposure was your neg result. 

Link to comment
Share on other sites

@honorejaxon, did you actually have lesions that a doctor looked at and told you were herpes (was it swabbed) or did you simply have sex and are now fearful of having caught something?

The blood tests aren't terrible.  They simply shouldn't be trusted as absolutely as they are.  Even in this study the IgG blood test was still 70-82% accurate. They are one of several tools, including a doctor's expertise, that should be used to make a diagnosis. 

Link to comment
Share on other sites

I haven't read the whole paper (costs to do so) but there are a few comments to make.

The sample size is very small. There are similar paper which much larger sample sizes that form the the manufacturers' accuracy statements.

The diagnosis of these people is 100% owing to positive swabs.

Having multiple tests lifts the accuracy to over 90% at least in this study.

It follows that if you do not have lesions to swab or swab negative, then your particular chance of a false negative blood test is approaching 0%.

Link to comment
Share on other sites

25 minutes ago, StayingUpbeat said:

@honorejaxon, did you actually have lesions that a doctor looked at and told you were herpes (was it swabbed) or did you simply have sex and are now fearful of having caught something?

The blood tests aren't terrible.  They simply shouldn't be trusted as absolutely as they are.  Even in this study the IgG blood test was still 70-82% accurate. They are one of several tools, including a doctor's expertise, that should be used to make a diagnosis. 

I had a couple doctors look at me and say I had a groin fungal infection. But I think I went in too late. Maybe I even have genital hsv 1 as I was positive for type one and I've heard the IGG tests are even better for two than type one. My doctors did not swab anything. Just visual and thought I was probably fine. Then I went on my own and drove quite q distance and paid for a IGG test almost five months after and was told to move on by my doctor and Terri warren who runs a forum and clinic.  She said the tests are 98 percent accurate after four months based on a lot of studies. This was based on 33 people. 

Link to comment
Share on other sites

4 minutes ago, honorejaxon said:

I had a couple doctors look at me and say I had a groin fungal infection. But I think I went in too late. Maybe I even have genital hsv 1 as I was positive for type one and I've heard the IGG tests are even better for two than type one. My doctors did not swab anything. Just visual and thought I was probably fine. Then I went on my own and drove quite q distance and paid for a IGG test almost five months after and was told to move on by my doctor and Terri warren who runs a forum and clinic.  She said the tests are 98 percent accurate after four months based on a lot of studies. This was based on 33 people. 

Many years before I actually caught herpes I had a situation very similar to yours. I got all worked up about what turned out to be jock itch.  I don't know the details of your situation nor am I a doctor but if a doctor literally looked at your condition and didn't suspect herpes enough to even swab or recommend a blood test.  That, along with a negative blood test, makes it sound to me (again not a doctor) like you're in the clear.

Edited by StayingUpbeat
Link to comment
Share on other sites

I had nothing to swab well... at the time had no clue what hsv was. Just assuned fungal, been years and i finally found this site and understoof about the igg tests found a uk spot for private igg tests as our sexual health clinics seem to not be arsed about hsv or care about it. Got negative results but i know its false as i definatly have had a cold sore.

Link to comment
Share on other sites

4 hours ago, fixme1 said:

I had nothing to swab well... at the time had no clue what hsv was. Just assuned fungal, been years and i finally found this site and understoof about the igg tests found a uk spot for private igg tests as our sexual health clinics seem to not be arsed about hsv or care about it. Got negative results but i know its false as i definatly have had a cold sore.

The IGG tests are less accurate for hsv 1. From everything I've learned they're far more accurate for hsv 2 than 1 and miss about one out of ten hsv 1 infections. Although this study suggests they may not be that great lots of larger studies have shown they are quite accurate at the right time frame although obviously not perfect 

Link to comment
Share on other sites

  • 5 months later...

Great. 

How damn hard is it to make an anti-body test? I know that HSV was lost in the roar of HIV in the 80's, but frankly, some of us would like to get an accurate test result! 

Link to comment
Share on other sites

On 1/19/2016 at 1:39 AM, fixme1 said:

But.i am sure i have it genitally, not had a outbreak as such in 2 years but the foreskin and head is constantly tender and red. 

That doesn't sound like herpes to me. I'd get a prescription for acyclovir/valtrex and take it for a month. If your symptoms don't go away, you likely have something else. Maybe you could tell the doc you just want to experiment briefly for your own peace of mind.   

Edited by Voyager2
Link to comment
Share on other sites

still to this day it is the same , no blisters or any outbreaks. dermatologists said it isnt hsv but I think otherwise... no moisturiser or anti fungals / hydrocortasines have sorted it. just stays the same. hopefully these accurate tests are out soon and i can get a better diagnosis

Link to comment
Share on other sites

If you haven't yet try the Zinc Test.  Get yourself a $20 can of zinc sulfate from Amazon and rub it into the area that you're having problems with for a week or so.

I'm not saying it will definitively tell you if you have HSV  but for most people I've talked to with HSV (that have tried this) it causes a mild outbreaks to be noticeable. 

I have no idea exactly why but HSV (and many other viruses) bind very tightly to certain forms of Zinc.  In theory it's supposed to lessen the recurrence rate but that claim seems dubious: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730471/

For me specifically it caused an area that I was having trouble with to form noticeable lesions (that could be cultured).  Certainly blood testing and swabs are better more definitive options but in your case it might be worth a shot to give your doctor something to culture.

Link to comment
Share on other sites

1 hour ago, StayingUpbeat said:

If you haven't yet try the Zinc Test.  Get yourself a $20 can of zinc sulfate from Amazon and rub it into the area that you're having problems with for a week or so.

I'm not saying it will definitively tell you if you have HSV  but for most people I've talked to with HSV (that have tried this) it causes a mild outbreaks to be noticeable. 

I have no idea exactly why but HSV (and many other viruses) bind very tightly to certain forms of Zinc.  In theory it's supposed to lessen the recurrence rate but that claim seems dubious: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730471/

For me specifically it caused an area that I was having trouble with to form noticeable lesions (that could be cultured).  Certainly blood testing and swabs are better more definitive options but in your case it might be worth a shot to give your doctor something to culture.

are you saying applying the zinc sulfate if you in fact have genital herpes you would have an ob why would someone want an ob? to prove they have herpes? I thought the zinc sulfate suppressed the ob? i am confused...

Link to comment
Share on other sites

You're already having the outbreak.  Again, in my experience, it seems to make outbreaks more noticeable not any more or less painful.

The "theory" in the paper cited is that it reduces the recurrence rate because the virus is exposed for longer to the immune system per outbreak.  This is the part of the hypothesis that is likely nonsense but if the zinc sulfate cream helps people get answers that can be useful.

There is a whole thread of people who have tried it and the experiences seem more-or-less similar: a very noticeable outbreak followed, for some, by decreasing severity of future outbreaks (with continued application).  I'm not sure I buy the second half of that (people will convince themselves a lot of things are helping) but the first half seems to hold-up.  In a study done by the makers of Zicam treatment with zinc ended up making the first treated cold sore more noticeable (they weren't looking at time to recurrence).  In this context people in the shoes of @fixme1 should be able to use it as another data point when it comes to a diagnosis.

The up-side is that the cream doesn't seem to have any effect on HSV free skin (aside from being a little crusty when it dries).  Hence the reason I'm throwing it out there as a "test".  I'd love to hear others experience.

Certainly any noticeable blister that appears should be cultured for confirmation by a medical professional.

Edited by StayingUpbeat
Link to comment
Share on other sites

im scared to try it but its a must and I need to know. then i can accept it all and know what im doing with myself. I feel stuck in the middle now.

Link to comment
Share on other sites

On ‎7‎/‎19‎/‎2016 at 7:28 PM, LillianPanos said:

are you saying applying the zinc sulfate if you in fact have genital herpes you would have an ob why would someone want an ob? to prove they have herpes? I thought the zinc sulfate suppressed the ob? i am confused...

I did it. It caused ob's to come out of hiding. It sucked for a few days but since doing it I have not had an ob. I will reapply every 10 days or so even if nothing is there and miniscule ob's occur but have become less and less everytime. I am very happy with the kirkman zinc sulfate cream. You can check my past posts about my experience with this.

Link to comment
Share on other sites

Assuming, of course, what you're dealing with is actually HSV it could take a while.  Remember this doesn't actually cause an outbreak it simply makes it more noticeable (in theory).

Link to comment
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Donate

    If Honeycomb has helped you, please help us by making a donation so we can provide you with even better features and services.

  • The Hive is Thriving!

    • Total Topics
      72.1k
    • Total Posts
      486.1k
  • Posts

    • WilsoInAus
      I really suggest that the best thing is for both you and your boyfriend to obtain the Westernblot HSV test. He has a 50%+ chance of being positive and you have a 50% chance of being negative
    • WilsoInAus
      Hi @kpn the first thing to note is that it is all OK to have HSV-1 or indeed any HSV type. It is not negligence, it is just being human. Oral HSV-1 is not an STD in the sense that the primary transmission is non sexual and the majority of it occurs between parents to children. If any of your children contracted HSV, you would know it. It wouldn't be a silent infection for children. HSV-2 tends not to shed from the oral region for people who have it there in any event. At age 73, about 80% of the population has HSV-1. There is no reason to believe that your mother isn't one of those people. About half of all carriers of oral HSV-1 do not realise they have it and have no living memory of cold sores as they were infected when very young. The most logical explanation is that your mother has oral HSV-1 from her childhood and that your daughter doesn't have oral HSV. Not that it is relevant to anyone but yourself, but your wife might find she actually has genital HSV-1 having had an untyped swab when she was diagnosed.
    • WilsoInAus
      Hi @Dylan86 and welcome to the website. First note that you cannot pragmatically become infected with HSV-1 from sharing a drink. If you carry HSV-1, it did not come from that episode. As such it is extremely unlikely HSV-1 is the primary cause of your issues. Can the WB miss a HSV-1 infection? Rarely but its feasible in less than 1% of carriers who test with WB. Note that the WB does not have values, it has positive or negative as you say. It is way more accurate than IgG as it looks for all 30+ antibodies that are in your blood for HSV. Could you have HSV-1? Yes it is feasible, but it would be a very old childhood infection. Could HSV-1 be causing your oral issues? No herpes will not cause the burning mouth syndrome you describe. Could some of the lesions be herpes related? It is feasible if you are a carrier. But it is unlikely to be the primary cause of the issues, but its an opportunistic virus that can cause issues when something else is taxing your immune system. The best thing you can do is the PCR test on a oral lesion and that will be pretty definitive. Either way, in summary. I'd suggest there is <1% chance you are part of about 70% of the population that has HSV-1. Further there is less than a 1% chance that herpes is the primary cause of your issues.   
    • kpn
      My wife has had hsv 2 for around 8 years. We have two young children 3 years old and 18 months old. My wife only had one outbreak when she was first infected so we didn't worry too much about passing it on to our children. I understand the risk to be pretty low under those circumstances. I don't believe my wife took antivirals during either pregnancy. My younger child has diaper rashes pretty often and has had what I thought was hand foot and mouth disease. That was going around the daycare a while back. I haven't really given it much concern though.  About a week ago, my mother kissed my youngest on the lips. My kid was congested at the time but they pretty much always are. About 3 days later, my mother developed a cold sore on her mouth. She has never had cold sores in her life and she is 73 and happily married so she is not going around messing with anyone. She pointed to the fact she had kissed my youngest and presumed that is where she was infected. At first I said that's not possible since my child has never had any cold sores but since then I have really started to consider that maybe it is possible she contracted it from my daughter. This has me worried that my daughter does indeed have hsv2 and was shedding in her mouth. Does anyone have any experience with this? I am really losing sleep about this. Two people I care so much about got hsv from my negligence. I am fine if I were to contract it, I am not worried about what others think at this point in my life. I just don't want anyone else to have it. 
    • CHT
      Hello DavidGua.... based on the two pictures, I'm not seeing anything that resembles a typical herpes outbreak.  I am not sure what those spots are on your penis.  Please have a doctor take a look and I'm sure you'll get a proper diagnosis.  Have you ever received an HSV antibody test (IgG)?  Again, I doubt your symptoms are herpes-related but, if you'd like some peace of mind, you could request the IgG antibody test for HSV2.   Best of luck.... let us know if you have any other questions/concerns.
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.