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Beware of doxy and other drugs that supress NK activity


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I suspected that my high-dose doxycycline was affecting my ghsv infection. I was infected mildly in Nov and then had a bad outbreak in June/July which continued on and off until even now. When I say it continued, I mean it was itchy and red and uncomfortable. Anyway, I have been 400mg of doxy a day since June. The doxy helps me a lot with Lyme joint pain and nerve damage. Anyway, I found doxy is the only tetra class antibiotic that supressses Nk function by 50%. Nk function is what keeps the hsv latent. Our antibodies only help once we have an outbreak. Anyway, I plan on switching to biaxin and plaq. Plaq is the most aklaine drug one can take. I think this wil help keep the hsv latent.

1: Int J Immunopharmacol. 1984;6(1):51-4. Links

In vitro inhibition of natural killer cell activity by doxycycline.

Goh DH, Ferrante A.

The effect of four tetracyclines, tetracycline, rolitetracycline, oxytetracycline and doxycycline, on human natural killer (NK) cell-mediated cytotoxicity was examined in vitro. Doxycycline was the only tetracycline which inhibited the NK cell activity. At concentrations of 10 micrograms/ml the drug caused approximately 50% inhibition of NK cell mediated cytotoxicity against K562 target. The inhibition was not a result of a toxic effect of the drug on NK cells. These results support the previous findings that doxycycline shows immunosuppressive properties.

PMID: 6724766 [PubMed - indexed for MEDLINE]

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Btw, many young people take doxy for acne. So if you are taking it, you may want to switch to tetra or check out mino. I am not sure if mino has the same effect on nk function as doxy does, but it is worth a quick journal search.

Doxy is also used for infections.

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