Full paper here: https://www.sciencedirect.com/science/article/pii/S0264410X18315652
Note sure if anyone wrote about this. I couldn't find any results for VC2 in the site's search. This is a live attenuated vaccine from Louisiana State University. The results do not seem super promising, as reducing shedding/recurrance by < 70% pre-clinical is common in many discontinued vaccines. Still, research is being done, which is always great!
"Our studies also showed that VC2 vaccine decreases the clinical severity of acute and recurrent HSV-2 disease in guinea pigs when provided by intramuscular vaccination. During the primary infection, animals vaccinated with VC2 had a significant decrease in clinical severity and replicating virus in the vaginal vault. Prophylactic vaccination also decreased the quantity of virus in the DRGs when compared to the No Treatment group. The ability to protect neural tissue from latent infection probably contributed to the decrease in the number of animals with recurrent lesions by 67% and the number of days with recurrent vaginal shedding by 46%. This reduction in shedding is particularly important because transmission of HSV-2 to uninfected persons is largely due to asymptomatic shedding , ."
"When tested as a therapeutic vaccine, i.e., one designed to decrease recurrent disease and recurrent virus shedding in those already infected with HSV, the VC2 vaccine was not effective although it did reduce recurrent shedding, at least when compared to the gD2 vaccine. This may be because live attenuated vaccines have only limited replication in hosts that are already infected and thus do not have much of an impact in improving the immune response. Because infected hosts have frequent reactivations of virus that would be similar to a live vaccine inoculation it may be difficult for the vaccine to improve the immune response unless it is able to induce responses not activated by the host’s recurrent virus replication."
I'm sure a lot of you Google "hsv2-cure" daily like me. Looks like there may be a twinkle of hope. Not a cure, but at least some new news.
Found a good article what do you think ?
Today i saw on Dr Josh Blooms comments about he is saying he contacted to Albert Einstein’s researchers to have interview about their vaccine.
I think this interview will make clear about how is going with their vaccine.
I reached out to Prof Frazer of Admedus Immunotherapies; you may know that he was the person who developed the vaccine for HPV (genital warts). I explained to him that I was trying to find a way to help, potentially though crowdfunding. I was quite surprised when he replied and passed my e-mail on to the CEO, Neil Finlayson. Now granted, the company is not that big, so passing on a mail isn't that surprising. However, Finlayson did e-mail me to say that their capital was currently directed at HPV research and in order to do Phase 2b HSV trials they were looking for $6m. Could I help to raise the money?
I was quite surprised by how candid they were, but I guess that answers my earlier post where it felt (from reading the Admedus fiancial report) that the company's HSV vaccine development did not seem to be going ahead fast enough.
The point of this post is that I am trying to hear from people who may have done crowdfunding for herpes research before. If I do set something up, I will not send links from this forum as it is against the rules. However, I would appreciate to hear from people who have experience in internet marketing, grassroots movements and crowdfunding.
I really think that instead of being on forums complaining about our condition and feeling helpless, we should start to do whatever we can to accelerate the research. Thanks
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