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This trial ends sanofi hsv-529

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3 minutes ago, Hansje said:

Dados el texto del enlace Que es para HSV-2 , Que es generalmente el tipo genital.

Experimental: HSV1+/HSV2-
Healthy volunteers who are infected wtih HSV-1 but not with HSV-2, as determined by serology testing.
Biological: HSV529
This is a replication-defective HSV-2 vaccine. 20 subjects in each of 3 study groups will be injected with vaccine or placebo in a 3:1 ratio as Day 0, Day 30, and Day 180.

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according to what I saw it seems that in this clinical trial, recruited groups of people including one with HSV-1, did not get much more besides sanofi not give much more information, rather it takes secret but there is of the few options that same test with type one

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In this comprehensive investigation of HSV529 prior to its evaluation in clinical trials, we confirmed that it is immunogenic and provides high level of protection against HSV-2 infection and disease regardless of HSV-1 serostatus at the time of vaccination. Importantly, it was also unable to replicate in two very sensitive mouse models of viral replication, as well as in guinea pig vaginal mucosa. These results suggest that HSV529 is appropriate for clinical investigation, that it is likely to be as effective in subjects who are also HSV-1 seropositive.

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"But when you get into normal cells in the body, it goes right up halfway through the replication cycle and then stops," says Knipe. "It has a large amount of viral proteins that can induce immune responses, but does not spread to other cells to cause disease." The vaccine is designed to build immunity in people who have not yet caught the virus but can also work to suppress the virus in people who are already infected, says Knipe. "We hope he did," he says, "but it will not cure the infection. It will induce an immune response strong enough to fight the virus anytime it starts reactivating. "

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DrearyDaysAhead
2 hours ago, siennabale234 said:

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