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This trial ends sanofi hsv-529

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3 minutes ago, Hansje said:

Dados el texto del enlace Que es para HSV-2 , Que es generalmente el tipo genital.

Experimental: HSV1+/HSV2-
Healthy volunteers who are infected wtih HSV-1 but not with HSV-2, as determined by serology testing.
Biological: HSV529
This is a replication-defective HSV-2 vaccine. 20 subjects in each of 3 study groups will be injected with vaccine or placebo in a 3:1 ratio as Day 0, Day 30, and Day 180.

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according to what I saw it seems that in this clinical trial, recruited groups of people including one with HSV-1, did not get much more besides sanofi not give much more information, rather it takes secret but there is of the few options that same test with type one

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In this comprehensive investigation of HSV529 prior to its evaluation in clinical trials, we confirmed that it is immunogenic and provides high level of protection against HSV-2 infection and disease regardless of HSV-1 serostatus at the time of vaccination. Importantly, it was also unable to replicate in two very sensitive mouse models of viral replication, as well as in guinea pig vaginal mucosa. These results suggest that HSV529 is appropriate for clinical investigation, that it is likely to be as effective in subjects who are also HSV-1 seropositive.

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"But when you get into normal cells in the body, it goes right up halfway through the replication cycle and then stops," says Knipe. "It has a large amount of viral proteins that can induce immune responses, but does not spread to other cells to cause disease." The vaccine is designed to build immunity in people who have not yet caught the virus but can also work to suppress the virus in people who are already infected, says Knipe. "We hope he did," he says, "but it will not cure the infection. It will induce an immune response strong enough to fight the virus anytime it starts reactivating. "

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DrearyDaysAhead
2 hours ago, siennabale234 said:

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    • StayingUpbeat
      It should be noted that the Gates foundation was part of a venture capital group that gave Genocea $30 million in support of their vaccine development efforts in the period when their lead candidate was an HSV-2 therapeutic vaccine (GEN-003): https://xconomy.com/boston/2012/10/10/genocea-snags-30m-from-gates-foundation-vcs-for-new-vaccines/ They have also provided 30 million dollars to the University of Washington's HSV efforts.  This time specifically on research into whether suppressing HSV results in a reduction in HIV transmission: https://honeycomb.click/topic/77503-donations-to-fred-hutch-center/page/21/?tab=comments#comment-493474  Far from inactive in HSV research they provide significant funding in the context of reducing HIV transmission.  It's a well established fact that genital HSV greatly increases the probably contracting HIV from an infected partner.
    • Cas9
      Human trials starting next year?  Not even close. It will be several years.
    • hunger4more
      Sounds like X-vaxs' biggest concern is prevention and erradication secondary..... 🤦🏻‍♂️
    • IAmDesperate
      Ahh thank you for the link, but sadly I have HSV1
    • Pitchbird
      It may be small scale but at least it shows me that I'm by far not the only one who isn't willing to disclose to casual partners anymore. The damage for oneself is too high to make it worth it imho: - seduction becomes difficult as guy if they know in advance - you're very likely to become a gossip object if it happens within your social circle - you get abandoned before it even starts to get intense - you end up lonely and depressed after being abandoned for such a reason Still, that doesn't answer the question if it's better to disclose properly out of nowhere during the relationship or wait for the symptoms to appear and pretend to be surprised and fake the doctor diagnosis afterwards. At the moment I think the true disclosure would be less likely to be accepted by the partner, but in case it works it would feel better in the end because there's less of a secret kept in the long run... and of course there's lower moral burden when disclosing earlier because you're handing over responsibility of risk exposure to the partner.
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