I have a friend who a few years ago had a swab test done which came up with hsv2 however still to this day they test negative on every blood test including western blot. Apparently they only had bumps/blisters the first few weeks but nothing has happened since, including no tingling or soreness and its been years for them. Theyve never gotten a positive blood test, always negative.
What are the chances of a false positive swab test? Is it possible their results were mixed up at the lab?
Should I send a link to the labbox testing for the guy I hooked up with? I told him I have HSV2 after the deed was done and of course promised to pay for any expenses for testing. I found the link to labbox through honey, but I’m worried if I send him the link the horrific description about hsv2 beneath the merchandise will give him a heart-attack. What should I do? I messed up and I’m trying to help without making it worse.
So ive tested negative for most std's but my doctor never gives me the viral load count?... Is this because im testing negative??.. How can i contract something if its undetectable?? Does that mean it's gone??
Okay I will provide a brief back ground then would just like opinions or advice. I had been extremely ill with a bad head cold for about 3 weeks that antibiotics were not helping. Even now 5 weeks later I still wake up with mild throat pain. I started feeling burning in my vagina and automatically assumed this was a yeast infection as I have been with my daughters father for 9 years now and have had 0 other partners during this time. About 4 days after the original vaginal symptoms I noticed small white ulcers inside my Labia (looked exactly like a canker sore but on my vagina). I immediately went to gyno who told me that it was herpes and started me on valtrex. I had taken a fluconazole 2 days prior as I had assumed yeast infection. The next day my symptoms were gone and the Ulcers were practically healed as well. I don’t know if I can attribute this to fluconazole or valtrex. I had cultures done which were both negative, and igm which was negative both 1 and 2. Then an igg negative type 1 and positive type 2 at a 1.11. I was devastated to get a result 0.01 over being equivocal or negative. Also of note my partner got tested and he was negative for everything and has never had symptoms. So I believed I must have got this over 10 years ago when I was in high school and carried it this whole time and even had it when I had my daughter. I decided to go to my previous gyno (went to a new doctor first time as I had just moved). He ordered another hsv2 igg. And this one was NEGATIVE at a 0.84. I am conflicted as to what I should do. I did not think my “outbreak” looked like herpes personally, but I had an expert telling me it did. I was just so extremely sick. The second test was only 3 weeks after the first. This has been extremely emotionally exhausting for me. Especially as a mother because my mind was spinning thinking I could have hurt my child at birth or given it to her in her short life so far. My partner doesn’t think I need more testing and I am leaning toward just waiting till my next pregnancy and doing another blood test then. Is that crazy? Thanks
For those with questions related to IgM and IgG antibodies and the body’s immune responses here is an explanation an actual Herpes researcher himself (whose name I will not reveal) so new members are not stuck in the dark with explanations from unqualified members:
IgM is produced upon primary exposure, but those wane and never come back. IgG is produced after what's called class switching, and appears late in the first response (at extremely low levels), then higher and higher levels upon each subsequent exposure. If there is no exposure for a long time, the levels of IgG drop and are not protective. The best example of this is the need for regular tetanus booster shots; if you are not exposed to tetanus toxin between boosters, the protective level of IgG produced from the vaccine drop to a non-productive level; the booster gives the immune system a reminder and gooses up the IgG level to be protective again. In the case of herpesviruses, if the virus remains latent for a very long time, whatever protective immune reaction you had to it can wane and no longer be protective when a OB now occurs.
Bottom line: primary exposure to anything (vaccine, first time your seeing an infectious agent, allergen, etc.) will generate an IgM response. Those B cells that produced IgM will go into memory, where they will be available to respond to a second or subsequent exposure. If the same antigen is encountered again, genetic changes take place in those memory cells that allow them to switch to producing IgA, IgG, and/or IgE, all of which are more effective for a protective response. If the stimulus reappears (usually we're talking 6-8 week increments between exposures), the IgG/IgE/IgA response is boosted even more; essentially your immune system is being told that whatever this antigen is, you keep getting exposed to it and the previous level of protection was clearly not enough; we gotta do more.
If the stimulus is cleared and not encountered again, eventually the level of protective antibodies will wane; it's a way for your body not to waste valuable energy resources on something it doesn't need. Hence the need for periodic booster shots; you remind your waning protective response that this agent needs a higher level of antibodies to be protected. By reintroducing your immune system to the antigen, you're telling your immune system to boost its IgG/IgA/IgE against it.
The way this applies to herpes is that your first antibody response from primary exposure will ALWAYS be an IgM response. However, that it frequently overlooked because it can happen even in the absence of signs or symptoms. Each OB acts like a stimulation, leading to the class switch to IgG or IgA antibodies against the virus. Each measurement of the antibody level, though, is a snapshot in time; one cannot tell when or how stimulated the immune system was. One must follow the course of the antibody levels. If they are waning over time, then the infection has already passed and your body is winnowing out unneeded antibodies (and cells producing those antibodies). If the levels are waxing, then you were recently re=stimulated to produce antibodies. If the levels are staying the same, there's not much one can say except you've had, or are having, an immune stimulus.