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Second_chance

Any updates on Admedus Vaccone

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Second_chance

Does anybody have an update on the Admedus Vaccine other than the last vague statement they put out a couple of months ago? I was really rooting for Professor Frazier to surpass all expectations and bring an end to this horrific nightmare. Any updates would be greatly appreciated. 

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Evaluate

The study, in Phase II, hasn't concluded yet.  The results are expected around January to March 2017.

Here's a description http://www.proactiveinvestors.com.au/companies/news/167602/admedus-ltd-receives-some-more-positive-results-from-hsv-2-study-167602.html

The interim results are inconclusive, especially when the placebo group is showing similar results.  Initial reaction to the results hasn't been that great.

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2 hours ago, Justin Owens said:

Will the vaccine also help with people suffering from cold sores as well?

Possibly, but not for sure.  The vaccine is targeted at HSV-2, but there could be cross protection.  It's early to say and I'm not sure if they intend on testing the vaccine on HSV-1.  Genocea, for example, has an interest in testing their HSV-2 vaccine (GEN-003) in HSV-1 at some point, but this information is only known thanks to their CEO communicating here on the board.

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RVX Patient and Investor

i want any and all approaches to work...  but subunit vax attempts have failed at least 6 times already.

Frazier has credibility from a business POV b/c of his HPV subunit vax, but just b/c he did that doesn't mean he can make a subunit vax for HSV.  HPV is a wimp by comparison.

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11 hours ago, Justin Owens said:

I thought there was a 81% reduction?

In HSV-2 shedding, no testing has been done for HSV-1.  Note that HSV-1 and HSV-2 are different strains of the same virus.  Just because it shows promise for one does not automatically mean it will for the other strain.

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Joseph_Esp
On 30/11/2016 at 2:50 AM, Evaluate said:

The study, in Phase II, hasn't concluded yet.  The results are expected around January to March 2017.

Here's a description http://www.proactiveinvestors.com.au/companies/news/167602/admedus-ltd-receives-some-more-positive-results-from-hsv-2-study-167602.html

The interim results are inconclusive, especially when the placebo group is showing similar results.  Initial reaction to the results hasn't been that great.

Seems like you are pretty well informed. What´s your feeling about the multiple vaccines etc.? Any reasons for joy?

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13 hours ago, Joseph_Esp said:

Seems like you are pretty well informed. What´s your feeling about the multiple vaccines etc.? Any reasons for joy?

I think there is.  Without going into the various vaccines three stand out as most promising:

Halford's Vaccine - it's too early to say but the approach he has certainly got people a buzz.  He is taking a very different path to testing than the other vaccines so it's hard to give a timeline.  He's finished phase I clinical trials but more information is needed to really know its effect.

Albert Einstein College of Medicine - this vaccine has HSV mutated without gD-2, a protein almost all other vaccines possess and have concentrated on.  I believe they're onto something with removing it from their vaccine.  The types of tests they've performed on mice are quite interesting and show a very strong immune response.  They are close but not yet in clinical trials.  This one has shown cross protection in both HSV-1 and HSV-2 in mice.

GEN-003 - this won't be therapeutic cure but so far it is showing modest results.  It's in phase II clinical testing.  At best this will be helpful in reducing shedding and symptoms for many people and combined with antivirals it has the potential to bring much needed relief.

Edited by Evaluate

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44 minutes ago, Justin Owens said:

What are your thoughts on Ian Frazers vaccine?

We really haven't received any result to say one way or the other thus far.  It may give some benefit though, but it's too early to say.  The phase II results should come out in the first quarter of this year (January/February/March) and should give us more information about its viability.

Edited by Evaluate

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hopeful Rylee
On Tuesday, January 03, 2017 at 2:09 AM, Evaluate said:

I think there is.  Without going into the various vaccines three stand out as most promising:

Halford's Vaccine - it's too early to say but the approach he has certainly got people a buzz.  He is taking a very different path to testing than the other vaccines so it's hard to give a timeline.  He's finished phase I clinical trials but more information is needed to really know its effect.

Albert Einstein College of Medicine - this vaccine has HSV mutated without gD-2, a protein almost all other vaccines possess and have concentrated on.  I believe they're onto something with removing it from their vaccine.  The types of tests they've performed on mice are quite interesting and show a very strong immune response.  They are close but not yet in clinical trials.  This one has shown cross protection in both HSV-1 and HSV-2 in mice.

GEN-003 - this won't be therapeutic cure but so far it is showing modest results.  It's in phase II clinical testing.  At best this will be helpful in reducing shedding and symptoms for many people and combined with antivirals it has the potential to bring much needed relief.

I thought the Einstien vaccine was a preventative... Like it wont help those already infected?

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3 hours ago, hopeful Rylee said:

I thought the Einstien vaccine was a preventative... Like it wont help those already infected?

It's early to say.  So far, in the mice, they've only tested the ability to prevent disease.  By looking at the type of immune response it is producing in mice, it is suggestive that this immune response could help keep those who are already infected from experiencing further symptoms (in my layman opinion).  The key here is they are producing a strong antibody and t-cell response.  The fact that they can take one mouse's blood and transfer immunity to another is quite promising in demonstrating a strong immune response.

More study is needed to say one way or another, but I am very hopeful with this vaccine.

Edited by Evaluate

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hopeful Rylee
15 hours ago, Evaluate said:

It's early to say.  So far, in the mice, they've only tested the ability to prevent disease.  By looking at the type of immune response it is producing in mice, it is suggestive that this immune response could help keep those who are already infected from experiencing further symptoms (in my layman opinion).  The key here is they are producing a strong antibody and t-cell response.  The fact that they can take one mouse's blood and transfer immunity to another is quite promising in demonstrating a strong immune response.

More study is needed to say one way or another, but I am very hopeful with this vaccine.

Thanks. Is it even close to trials and do all FDA trials take 10 years?

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1 minute ago, hopeful Rylee said:

Thanks. Is it even close to trials and do all FDA trials take 10 years?

FDA trials normally take 7-10 years.  With new FDA rules to expedite some of the trial aspects, we may see trials becoming shorter.  I'm still not sure what affect the new legislation will have on trial times.

It's close since they've got animal trials under their belt.  There has been nothing published about a timeline, however, if I had to guess probably within a year.

 

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Sally89

Don't forget that IBM created a virus killer too. They want to develop either soaps or anti-viral wipes with it. Not sure of timeline though. 

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12 minutes ago, Sally89 said:

Don't forget that IBM created a virus killer too. They want to develop either soaps or anti-viral wipes with it. Not sure of timeline though. 

My understanding from the articles I've read that the technology you speak of is to help prevent the spread of viruses, but not treat/cure them with those who already have them.  This would be a very big thing for hospitals or places with high foot traffic to help reduce the spreading of germs.

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Sally89
2 hours ago, Evaluate said:

My understanding from the articles I've read that the technology you speak of is to help prevent the spread of viruses, but not treat/cure them with those who already have them.  This would be a very big thing for hospitals or places with high foot traffic to help reduce the spreading of germs.

Yes, I want a cure but I would be happy with the no transmission option first. 

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agamemnus

You can probably forget Admedus. The results weren't statistically significant against baseline. When I emailed to get clarity after speaking with IR, I received silence. I then called IR and got a disconnected number thing. (might have been an anomaly, but I didn't bother to call again.)

Edited by agamemnus

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JHenry

I will remain optimistic for all researchers and projects until told otherwise AND realize that when efforts fall short of the mark, we still learn from our disappointments and advance the battle further.

Henry 

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Freddy Fender
17 hours ago, agamemnus said:

You can probably forget Admedus. The results weren't statistically significant against baseline. When I emailed to get clarity after speaking with IR, I received silence. I then called IR and got a disconnected number thing. (might have been an anomaly, but I didn't bother to call again.)

Who is IR and what is the phone number you called that was disconnected?

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Disc0rdant
15 minutes ago, Freddy Fender said:

Who is IR and what is the phone number you called that was disconnected?

Investor relations.  They probably just changed their phone #....

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RVX Patient and Investor

Investor Relations i'm guessing.

do'h!  didn't see ur post discordant!

Edited by RVX Patient and Investor

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Disc0rdant
1 minute ago, RVX Patient and Investor said:

Investor Relations i'm guessing.

do'h!  didn't see ur post discordant!

You are funny as hell RVX.

Homer....

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