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    • asdfz
      Hi, here seeking advice from those on Famvir for daily suppressive therapy. I’ve tried valtrex and get nasty side effects so I’m on Famvir. I was taking 375 every 12 hours which kept OBs away but I was getting 2 migraines a week. My doc said to try 250 every 8 hours. I’ve been on that about a week and constantly feel tingles. Is that normal when adjusting meds? Will it go away as my body adapts? Please help! 
    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
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Scared25

Question about chances of spreading hsv

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Scared25

Hi. I'm newly diagnosed (two days ago....ghsv-1). I have a trip coming up, my little girl and I are going on a cruise. I'm wondering if it's safe to swim in a pool with my child and other people, also is it safe to go in a hot tub? what are the risks with an outbreak and without an outbreak? thanks for your help. I'm trying to find a way to pick up the pieces and feel like myself again, while keeping my child safe. 

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Blahdittilyblah

0 risk with or without an OB in that scenario. Don't take a shower use a towel then share it with someone but as far as swimming or getting in the hot tub no one will be st risk or we'd all have it by now. The virus is unstable outside of the body. 

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Lisajd

Genital HSV 1 for your information is also lower risk than the other two types and also you have less outbreaks and Less viral shedding but I think it's important for you to try and educate yourself about this virus so you understand what the risks are and how you prevent it spreading but in terms of your daughter and swimming yes zero risk

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Scared25

Thanks! that's why I joined here, for support and information. any advice that you can give I'd be grateful for. it's been a rough couple of days trying to figure out how my life will ever be normal again. although, I'm wondering if I've had this longer than I thought. Tell me what you think.....about a year and a half ago I had a lot of itchiness and some pain inside my vagina. I went to my gynecologist during that time for my annual and mentioned that I had been having this pain for about a week. when she examined me she said she saw a small cut/ulcer and swabbed it to see if it was herpes. the test came back negative but she said that may be bc it was already almost healed or bc it really wasn't herpes. I had that pain one more time 2 months later and then that was it. this time started with that same pain....however it developed into a full blown outbreak. I had recently taken the morning after pill, ehich may have messed with my hormones and found out I also have a bacterial yeast infection. my doctor said that may have caused the bad outbreak. so, I'm thinking I may have had this for a while. but who knows. I've had the same partner for 10 years....neither of us have ever had a cold sore in the 10 years that I've known him. could you get hsv1 even if your partner has never had a cold sore? sorry for the super long post 

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Disc0rdant

Yes.  You can get ghsv1 without a cold sore.  Have him get tested.  I bet he has hsv1.

In any event, take care of yourself.  Keep your blood sugar low and try to eat foods that are anti inflammatory.  Seems to help me with OHSV1...

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Disc0rdant

Even if he has hsv1, it doesnt mean he gave it to you....

Many folks test negative for hsv1 after a while.  Dr.'s dont know why.

I always test + for hsv1, though.

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