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    • asdfz
      Hi, here seeking advice from those on Famvir for daily suppressive therapy. I’ve tried valtrex and get nasty side effects so I’m on Famvir. I was taking 375 every 12 hours which kept OBs away but I was getting 2 migraines a week. My doc said to try 250 every 8 hours. I’ve been on that about a week and constantly feel tingles. Is that normal when adjusting meds? Will it go away as my body adapts? Please help! 
    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
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vyelake

Feeling alone

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vyelake

Hello everyone:

I was diagnosed with Genital Herpes two weeks ago.  I finished my course of acyclovir and have now started on Valtrex.  I spend a lot of my free time doing research to find out what Herpes is and what to look for so I can know when I'm having an outbreak.  A couple weeks ago I was devastated, but I try not to let myself get too down.  I have a supportive boyfriend who is being very patient with me while I'm finding all this information out.  As we have found out, he is asymptomatic (lucky him!)

Just when I thought I finished my first outbreak, it seems like I am having another one again, it's a bit frustrating, and sometimes I feel as if I have no one to talk to. I live in a really tiny town of about 200, and the closest doctor is about 2 1/2 hours away from me.

I am hoping that this community will be a support to me.  It's already so comforting to know that there are others like me.  

 

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WilsoInAus

Hi @vyelake and welcome.

Did you find out whether you have HSV-1 or HSV-2 as genitally, there is a bit of a difference in outbreak frequency expectations. Perhaps taking antivirals will help for the next handful of months but after that there is little reason not to let your body do the work of addressing the virus.

You can't reinfect your boyfriend so life should be able to return to be exactly as it was pre infection. 

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Felix12

You are not alone love, and one thing to always keep in mind is that those lucky folks who don't carry hsv-1 or hsv-2, they are actually in the minority of the population. Most people have herpes. Period. As for the symptoms, they vary, but there are ways to manage them so keep your head up and you'll tackle this. We all will and are and will continue to be stronger for it.

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vyelake
3 minutes ago, WilsoInAus said:

Hi @vyelake and welcome.

Did you find out whether you have HSV-1 or HSV-2 as genitally, there is a bit of a difference in outbreak frequency expectations. Perhaps taking antivirals will help for the next handful of months but after that there is little reason not to let your body do the work of addressing the virus.

You can't reinfect your boyfriend so life should be able to return to be exactly as it was pre infection. 

Hi!

It is HSV-2.  I'm hoping for the anti-virals to suppress my outbreaks, I have read that if you have HSV-2, that outbreaks are more frequent.  To be honest, I am scared of outbreaks, that's why when my doctor told me about Valtrex, I didn't hesitate to get the prescription.  

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WilsoInAus

Did you have a swab test? Are you sure if it was a culture that it was properly typed? Does your boyfriend get oral cold sores and did you receive oral sex a few days before the outbreak?

These are a few questions to ask yourself to make sure you do know the type. Many people just get a culture that is positive for HSV and assumed to be 2 given genital location.

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vyelake
2 minutes ago, WilsoInAus said:

Did you have a swab test? Are you sure if it was a culture that it was properly typed? Does your boyfriend get oral cold sores and did you receive oral sex a few days before the outbreak?

These are a few questions to ask yourself to make sure you do know the type. Many people just get a culture that is positive for HSV and assumed to be 2 given genital location.

I did have a swab test, two actually!  One in the emergency room when I thought I had a UTI and the doctor there said that it visually looked like herpes and that he would send a swab, and another when I went to see a doctor a few days after that.  I only heard from the doctor I most recently saw with my test results that they were HSV, and that she believed it to be HSV-2 (her words).  I had vaginal sex before the outbreak.  I just asked my boyfriend if he'd ever had a cold sore, and he said no (:rolleyes: although I'm not sure if I believe that!).

Perhaps it could be HSV-1.  Would I have to get tested again to know for sure?

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Lisajd

There are things that can trigger an outbreak including sex certain foods and stress so be mindful of these things e specially in the early stages.  The other thing is that's hormones as in your periods country girl an outbreak with these things to do with your appointment but you'll be best to look at what you were doing when you are getting an outbreak so if you can that determine what a cause may be

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