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HSV529 Phase 1 Completed March 10, 2017

123kid

By 123kid,
in Herpes Cure Research

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for ev4r Established Member

for ev4r

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Posted

 

Have completed a phase one trial. But they have another trial in progress also phase one. This last will end in 2018. Personally I think this vaccine has many chances of success.

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valleynovascotia Acknowledged Support Member

valleynovascotia

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On 3/31/2017 at 7:23 AM, for ev4r said:

 

Have completed a phase one trial. But they have another trial in progress also phase one. This last will end in 2018. Personally I think this vaccine has many chances of success.

So this vaccine could be out in 2018?

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Cas9 Platinum Support Member

Cas9

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2 hours ago, valleynovascotia said:

So this vaccine could be out in 2018?

There are at least three phases in a trial, not one. And sometimes there are shorter sub phases. So typically it's:
Phase I
Phase II
Phase III

And you can even have sub phases. For example Phase IIa. But the sub phase would generally be shorter. Phase lengths vary. Generally, each phase runs from 2 - 3+ years.

ev4r was simply saying that phase I, in it's entirety, would be complete by 2018. There will be two more phases to follow. So you're looking at another 5 - 7 years. So this vaccine would not be available, assuming success, until the mid 2020s.

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valleynovascotia Acknowledged Support Member

valleynovascotia

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1 minute ago, Cas9 said:

There are at least three phases in a trial, not one. And sometimes there are shorter sub phases. So typically it's:
Phase I
Phase II
Phase III

And you can even have sub phases. For example Phase IIa. But the sub phase would generally be shorter. Phase lengths vary. Generally, each phase runs from 2 - 3+ years.

ev4r was simply saying that phase I, in it's entirety, would be complete by 2018. There will be two more phases to follow. So you're looking at another 5 - 7 years. So this vaccine would not be available, assuming success, until the mid 2020s.

Better late than never.

 

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HarryAUS Honeycomb Member

HarryAUS

Posted
Posted
On 22/06/2017 at 8:53 AM, Whyyyyy said:

What happened to this?

I've been wondering this too. I was very positive about this project but ACAM/HSV529 has been in some form of phase 1 trial for soooo long, since 2013 I think. Here's the link to the latest phase 1 trial, sponsored by the the Fred Hutchinson Cancer Research Center https://clinicaltrials.gov/ct2/show/NCT02571166

I'm not sure whether the fact it is taking so long is a good or bad thing? Sanofi Pasteur is the world's largest vaccine company, surely this means the trials have delivered some positive interim data that's causing them to spend more time and money investigating it?

 

 

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90125 Honeycomb Member

90125

Posted
Posted (edited)

There is another post about this - and it's not good news.

I am so disappointed - and really down....

I just read the other post.

Here's the link:

 

 

 

 

 

 

 

Edited by 90125
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Voyager2 Established Member

Voyager2

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Posted

The recent phase 1 write up of Sanofi's HSV529 vaccine says it is safe, which is good news. Trial participant Stayingupbeat says it didn't help with his own symptoms, which is not what we wanted to hear, but since it is also being tested as a prophylactic vaccine, it still might be of use. The other two prophylactic vaccines are at least a year from the clinic. Herpsters might have to rely on Pritlivir and Acyclovir until CRISPR arrives.   

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ManagingIllness Established Member

ManagingIllness

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Posted (edited)
22 hours ago, HarryAUS said:

Based on what?

My apologies. I thought this was another vaccine. This is the internasal vaccine from NanoBio. It's one of the most promising upcoming vaccines. My apologies for the misinformation. 

Here is the official paper detailing the results on NCBI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630753/

Edited by ManagingIllness
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cracked Acknowledged Support Member

cracked

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Posted
1 hour ago, ManagingIllness said:

My apologies. I thought this was another vaccine. This is the internasal vaccine from NanoBio. It's one of the most promising upcoming vaccines. My apologies for the misinformation. 

Here is the official paper detailing the results on NCBI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630753/

Wait, so is this to induce an immune response and create HSV-2 antibodies in seronegative individuals who are symptomatic for HSV?

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ManagingIllness Established Member

ManagingIllness

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Posted
On 1/12/2018 at 1:06 AM, cracked said:

Wait, so is this to induce an immune response and create HSV-2 antibodies in seronegative individuals who are symptomatic for HSV?

No no, the groups are as follows: HSV1 but not 2, both, and neither.

 Quote "..3 serogroups: HSV1+ or -/HSV2+ (group 1), HSV1+/HSV2– (group 2), and HSV1-/HSV2– (group 3)"

"In addition, the vaccine induced significant levels of HSV2-specific antibody dependent cellular cytotoxicity (ADCC) after 3 doses in group 3 subjects compared with placebo (P < 0.001). "

Group 3 is the 'neither form of HSV group'. So, in that group there was a 'significant' boost in HSV2-specific ADCC.

Conclusion: 'The HSV529 vaccine was safe, well-tolerated, and immunogenic, eliciting significant neutralizing, gD, and ADCC-mediating antibodies, and modest cellular immune responses in HSV seronegative individuals.'

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cracked Acknowledged Support Member

cracked

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2 hours ago, ManagingIllness said:

No no, the groups are as follows: HSV1 but not 2, both, and neither.

 Quote "..3 serogroups: HSV1+ or -/HSV2+ (group 1), HSV1+/HSV2– (group 2), and HSV1-/HSV2– (group 3)"

"In addition, the vaccine induced significant levels of HSV2-specific antibody dependent cellular cytotoxicity (ADCC) after 3 doses in group 3 subjects compared with placebo (P < 0.001). "

Group 3 is the 'neither form of HSV group'. So, in that group there was a 'significant' boost in HSV2-specific ADCC.

Conclusion: 'The HSV529 vaccine was safe, well-tolerated, and immunogenic, eliciting significant neutralizing, gD, and ADCC-mediating antibodies, and modest cellular immune responses in HSV seronegative individuals.'

What is considered ‘significant’?

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Jimmyjimmyhuapua Established Member

Jimmyjimmyhuapua

Posted
Posted

When they started to this vax and when they are announcing phase 1 results ? I think they will be announcing phase 2 results after others will be marketing already a vax for hsv

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friendlyboy Established Member

friendlyboy

Posted
Posted
18 hours ago, cracked said:

What is considered ‘significant’?

Statistically significant with 95% confidence. The probability of obtaining this result, assuming the Null hypothesis (both populations are equal or the treatment had no effect) is true, is less than 0.05 (or a 5% chance of reporting results that aren't there, that is, a pretty low standard in science, in physics nothing under 4 sigma is considered worth reporting).

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ManagingIllness Established Member

ManagingIllness

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Posted
32 minutes ago, cindy010 said:

My name Cindy Lucas from US taxes for a year now i have been living with this virus called (Herpes) VIRUS and i have been taking some medications from my Doctor and there was no improvement, All thanks to God almighty for using Dr Abudu for curing my (Herpes) Virus with the help of his powerful root and herbs...Well i do not have much to say, with all my life i will for ever be grateful to him and God Almighty for using Dr, Abudu to reach me when i thought it is all over, today i am now happy after the medical doctor have confirmed my status Negative, i have never in my life believed that (Herpes) could be cure by any herbal medicine. so i want to use this medium to reach other persons who is suffering from any deadly disease you can contact Dr, Abudu on his email, iyayetemple@gmail.com or call or whatsapp him +2348051129648

SCAM from a con-artist. Contact a doctor on whatsapp eh? Sounds good! I'll start with my credit-card info.

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