University of Pennsylvania preclinical update

[JJ2017]

came across this article for those who find it interesting, looks like they are still working on the vaccine hopefully they will crack a permanent cure for both type 1 and 2 albeit this may be 15/20 years away from market. 

http://www.med.upenn.edu/apps/faculty/index.php/g20001882/p2712 

Harvey M. Friedman

Sita Awasthi

 

[LillianPanos]

Wow marvelous! something t look forward too.... next 2 decades!

34 minutes ago, JJ2017 said:

came across this article for those who find it interesting, looks like they are still working on the vaccine hopefully they will crack a permanent cure for both type 1 and 2 albeit this may be 15/20 years away from market. 

http://www.med.upenn.edu/apps/faculty/index.php/g20001882/p2712 

Harvey M. Friedman

Sita Awasthi

 

 

[JJ2017]

21 minutes ago, LillianPanos said:

Wow marvelous! something t look forward too.... next 2 decades!

 

hopefully the CRISPR technology will move faster then this, and you never know this research may help identify the sequence to edit. 

[Joseph_Esp]

"Dear Joseph

We are probably 2 years from getting our vaccine into people and maybe 7 years from knowing if it works. I am optimistic it will work, but testing in people is the only sure way to know".

That was H. Friedman, on an e-mail he sent me as answer when I asked him about his vaccine. While 7 years does not sound good to me, 15-20 years is an exaggeration. Nothing takes that long.

[Joseph_Esp]

Aw, by the way, he also said:

"Dear Joseph,

I am sorry to learn about your difficulties with genital herpes. The vaccine I am working on is aimed at preventing people from ever getting herpes. It is not a vaccine for treatment, at least not at this point. I have two thoughts that may help you.

1) A number of clinical trials are open for treatment of genital herpes with vaccines. You should do a Google search to see if any of the trials are in travel distance for you.

2) Many countries have Help groups for people with genital herpes. You are not alone. I don't know if you have searched for Help groups near you, but it is worth pursuing.

I hope you make a recovery!"

 

Just making sure I give you all info I have.

[JJ2017]

7 minutes ago, Joseph_Esp said:

Aw, by the way, he also said:

"Dear Joseph,

I am sorry to learn about your difficulties with genital herpes. The vaccine I am working on is aimed at preventing people from ever getting herpes. It is not a vaccine for treatment, at least not at this point. I have two thoughts that may help you.

1) A number of clinical trials are open for treatment of genital herpes with vaccines. You should do a Google search to see if any of the trials are in travel distance for you.

2) Many countries have Help groups for people with genital herpes. You are not alone. I don't know if you have searched for Help groups near you, but it is worth pursuing.

I hope you make a recovery!"

 

Just making sure I give you all info I have.

thanks for sharing i guess i homed in on the paragraph below but it didnt suggest he was making one just he thinks it would be effective. if he is still refining a formula surely it will take that long ....he will need to satisfy safety requirements before phase 1 then each phase can take 1.5-3 years with breaks between each phase for reporting. then approval of various bodies eg fda drugs tend to take longer to come to the uk so a perhaps a delay for that here, marketing, manufacturing, distribution. by the time its on the shelf 15 years could easily have gone by. 

 

immunization strategy to block immune evasion is feasible and that adding gC2 and gE2 antigens to a glycoprotein D (gD2)-based vaccine provides potent protection against genital herpes infection as a prophylactic vaccine and that a gC2/gD2/gE2 trivalent subunit antigen vaccine is highly effective as therapy for prior genital herpes.

 

[Joseph_Esp]

12 minutes ago, JJ2017 said:

thanks for sharing i guess i homed in on the paragraph below but it didnt suggest he was making one just he thinks it would be effective. if he is still refining a formula surely it will take that long ....he will need to satisfy safety requirements before phase 1 then each phase can take 1.5-3 years with breaks between each phase for reporting. then approval of various bodies eg fda drugs tend to take longer to come to the uk so a perhaps a delay for that here, marketing, manufacturing, distribution. by the time its on the shelf 15 years could easily have gone by. 

 

immunization strategy to block immune evasion is feasible and that adding gC2 and gE2 antigens to a glycoprotein D (gD2)-based vaccine provides potent protection against genital herpes infection as a prophylactic vaccine and that a gC2/gD2/gE2 trivalent subunit antigen vaccine is highly effective as therapy for prior genital herpes.

 

Well, don't wait till it reaches Europe, we'll be far too old. I'd rather take a flight and be treated there. Whatever money it cost, it'd always be a low price for me.

[JJ2017]

23 minutes ago, Joseph_Esp said:

Well, don't wait till it reaches Europe, we'll be far too old. I'd rather take a flight and be treated there. Whatever money it cost, it'd always be a low price for me.

fair point 

[LillianPanos]

Thanks for your optimism! 

3 hours ago, JJ2017 said:

hopefully the CRISPR technology will move faster then this, and you never know this research may help identify the sequence to edit. 

 

[Atrapasueños]

Desalentador para este tiempo varía gente de este foro ya habrá muerto

 

Discouraging for this time varies people from this forum will already be dead

[Hansje]

You never fail to say something to lift people up. 

[Atrapasueños]

Que puedo decir? Hay está una prueba y una respuesta del h friedman si eso lo vemos muy optimista para ustedes esta bien pero para mi no lo es, tal vez en unos años yo muera en un accidente o por otra enfermedad 

Lo único que hay para el hsv-2 es theravax, gen003, amadeus, y crispr a mediano plazo lo demás está muy lejos, aunque yo no me emocionó porque no se sabe bien si theravax o gen003 o amadeus será eficaz para el hsv-1 

Yo no soy un conformista yo quiero hechos reales no especulaciones

Yo agradezco a todos los científicos que luchan en busca de una cura o un mejor tratamiento para el hsv pero nada en el momento es real 

 

What can I say? There is a test and a response of the friedman h if that we see it very optimistic for you is well but for me it is not, maybe in a few years I die in an accident or another disease

The only thing that exists for the hsv-2 is theravax, gen003, amadeus, and crispr in the medium term. The rest is very far, although I was not thrilled because it is not known whether theravax or gen003 or amadeus will be effective for hsv-1

I'm not a conformist I want real facts not speculations

I thank all the scientists who are struggling for a cure or better treatment for the hsv but nothing at the moment is real

[Hansje]

At the moment you dying in an accident or from a disease isn't real either. Nobody working on that, fortunately. While many groups are working on HSV. Many more than on Addisson Biermer Syndrome, just to name one example. 

[Atrapasueños]

La muerte es real pero muchas personas quieren morir sin tener hsv súper moderadores dicen que el hsv a existido miles de años y que no había sido un problema, esos súper moderadores como saben que no fue un problema para las personas que tenían hsv y no existía medicamento alguno 

Si ven optimismo para una vacuna que puede salir dentro de 15 años está bien cada cabeza es un mundo pero la mía no piensa lo mismo para mi el hsv es un problema y para muchas personas más, algo más que me molesta es que comparen enfermedades yo no voy por los foros comparando enfermedades yo solo quiero ver investigaciones y resultados reales no especulaciones las farmacéuticas no tiene el derecho no la obligación de curar o realizar un nuevo medicamento de alguna enfermedad lo hacen por que es un negocio muy rentable., los obligados son los gobiernos ya que nuestros impuestos es para el beneficio de la población

 

Death is real but many people want to die without having super hsv moderators say that the hsv existed for thousands of years and it had not been a problem, those super moderators like they know it was not a problem for people who had hsv and did not exist No medication

If they see optimism for a vaccine that can come out in 15 years is okay every head is a world but mine does not think the same for me the hsv is a problem and for many people more, something else that bothers me is that they compare diseases me I do not go for forums comparing diseases I just want to see research and real results do not speculations Pharmacists do not have the right not the obligation to cure or make a new medication of some disease they do it because it is a very profitable business. Governments since our taxes are for the benefit of the population

[Hansje]

Recent scientific articles on HSV contain many real results. 

[Hansje]

If I die tomorrow, today I plant a tree. Some people say it was Mohammed, others Maarten Luther who said this. Maybe they both did. Good mentality to get things done. 

[Hansje]

Maybe in a way this is what Halford is doing. Planting a tree while he is dying. So that people may sit in its shade, even when he isn't there anymore. But we will remember him!

[Atrapasueños]

Claro pero sólo se queda en investigación, por eso Dr halford salió de USA para realizar sus ensayos ya que no tenía apoyo de su propia gobierno

 

Of course but only remains in research, that's why Dr. Halford left the USA to conduct his trials as he had no support from his own government

[Sophiebackster]

Hey guys i am super new to this forum, looking for advice as i am getting tested for this tomorrow

 

[Atrapasueños]

Puede que morir con hsv no sea problema para ti pero mucha gente no quiere esta enfermedad

 

Maybe dying with hsv is not a problem for you but many people do not want this disease

[Hansje]

I'm not planning in dying with HSV, but living my life to the fullest. And now if you don't mind, stop hijacking the thread. It is always the same with you. You seem obsessed with turning every single discussion here into a litany about your suffering and now even our impending death. Just open your own thread, may I suggest a title? "Life with HSV sucks and we will all die before there is a cure". You can live it up there with all the other members who are nice and negative as they should be.

 This here thread however is about potentially GOOD NEWS. In case we forgot: http://www.med.upenn.edu/apps/faculty/index.php/g20001882/p2712   

[SnowAngel]

8 minutes ago, Hansje said:

I'm not planning in dying with HSV, but living my life to the fullest. And now if you don't mind, stop hijacking the thread. It is always the same with you. You seem obsessed with turning every single discussion here into a litany about your suffering and now even our impending death. Just open your own thread, may I suggest a title? "Life with HSV sucks and we will all die before there is a cure". You can live it up there with all the other members who are nice and negative as they should be.

 This here thread however is about potentially GOOD NEWS. In case we forgot: http://www.med.upenn.edu/apps/faculty/index.php/g20001882/p2712   

Thank you! I'm honestly flat out tired of reading the sane old negative nelly posts. There are things coming for us in the near furture, that's huge!! I talk to people on here who are in extreme pain everyday but yet stay positive about things. This is a support group, we should be supporting each other and not dragging each other into depression. 

[JJ2017]

wow this convo got deep, i personally think its great that people are investing into research when the market is fairly crowded with plenty of hopeful vaccines coming out. appreciate this may not be therapeutic but if it means your partner doesn't need to share your burden im all for it. this could lead to a successful therapeutic solutions. its all about learning off each other. collaboration is key to success. 

[Atrapasueños]

Secuestrar hilos? Sólo di mi opinión y usted me confrontó di mi opinión sobre la vacuna  de tener que esperar 15 años para una vacuna preventiva es positivo para ustedes esta bien pero para mi no lo es para mi algo positivo es ver algo que va salir en 5 a 7 año 

Pero bueno como lo dije hace rato cada cabeza es un mundo y los conformistas sobran

 

Hijack threads? I just gave my opinion and you confronted me with my opinion about the vaccine having to wait 15 years for a preventive vaccine is positive for you is fine but for me it is not for me something positive is to see something that will come out in 5 to 7 year

But as I said some time ago, each head is a world and conformists are left

[Seeker1960]

We are all on the same side guys! We all want something than works and will relieve our symptoms as well as protect others. Patience is what we need also. There are other vaccines in the pipeline that should be out within 5 years maybe less. There might be other treatments sooner. Lets stay hopeful and not go down the path of darkness and despair. It is easy to go down that path if you suffer constant pain with this virus. Try to be hopeful in your pain and believe that there will be better days ahead. Right not even a year seems far off but yet we have a lot of reasons to hold on. Something is bound to go our way witb all the research and investment on this problem. 

Lets show eachother some love here as we are all united by the experince of having this virus.