Tricky HSV 1

[MoniqueLow]

Hi, I have a question regarding variations of HSV 1. I have it in two locations now, unfortunately, but I know that this evil virus likes any location. Next variations are herpes gladiatorus and herpetic whitlow (also keratis, but my question is not about this one).

If in a case of ohsv 1 (oral), virus hides in trigeminal nerve ganglia and genital ghsv 1 in sacral nerve root ganglia, then where it hides in a case of the mentioned variations: gladiatorus and herpetic whitlow?

It seems to me it can invade any part of nerve system (and likes it there despite general idea it prefers facial nerves).

What do you think?

[Cas9]

1 hour ago, MoniqueLow said:

Hi, I have a question regarding variations of HSV 1. I have it in two locations now, unfortunately, but I know that this evil virus likes any location. Next variations are herpes gladiatorus and herpetic whitlow (also keratis, but my question is not about this one).

If in a case of ohsv 1 (oral), virus hides in trigeminal nerve ganglia and genital ghsv 1 in sacral nerve root ganglia, then where it hides in a case of the mentioned variations: gladiatorus and herpetic whitlow?

It seems to me it can invade any part of nerve system (and likes it there despite general idea it prefers facial nerves).

What do you think?

I think the ganglion area for herpes whitlow inivolves the armpit. But don't quote me on that.

[Seeker1960]

Depending on the type of virus HSV 1 or 2 is said to favor certain areas. I believe that people can be infected with different strains of the same virus and that different strains can either be  nuero-invasive or neurovirulent. The nuero invasive strains tend to go beyond the trigeminal or dorsal root ganglion and invade the spinal cord and CNS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640688/

 

[WilsoInAus]

23 minutes ago, Seeker1960 said:

Depending on the type of virus HSV 1 or 2 is said to favor certain areas. I believe that people can be infected with different strains of the same virus and that different strains can either be  nuero-invasive or neurovirulent. The nuero invasive strains tend to go beyond the trigeminal or dorsal root ganglion and invade the spinal cord and CNS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640688/

 

This has not been demonstrated in humans, only mice.

HSV-1 and HSV-2 in exceptional circumstances pass through the meninge and can cause issues in the CNS. This is related more so to issues with the meninge than the virus itself. There is no evidence that a particular so termed 'sub strain' of HSV is more likely to result in these issues in humans.

[WilsoInAus]

2 hours ago, MoniqueLow said:

Hi, I have a question regarding variations of HSV 1. I have it in two locations now, unfortunately, but I know that this evil virus likes any location. Next variations are herpes gladiatorus and herpetic whitlow (also keratis, but my question is not about this one).

If in a case of ohsv 1 (oral), virus hides in trigeminal nerve ganglia and genital ghsv 1 in sacral nerve root ganglia, then where it hides in a case of the mentioned variations: gladiatorus and herpetic whitlow?

It seems to me it can invade any part of nerve system (and likes it there despite general idea it prefers facial nerves).

What do you think?

First the virus is not evil, it is one of God's DNA creations, no different to any other living animal or plant!

The body has 12 cranial nerve ganglions and 30 spinal nerve ganglions with dermatomes. Dermatomes represent the nerves that reach through our skin to provide sensory information to the brain.

Each ganglion is independent and herpes will in most every case not transfer beyond the infected ganglion. Once one is infected then the body's immune system provides very strong protection against another ganglion being infected. Each dermatome has a particular reach to the body that essentially are bands across your body, becoming vertical for your legs.

Cranial nerve 5 is the trigeminal nerve that is the nerve most infected by HSV-1. Its reach is across the face, lips nose etc.

Genital herpes will impact impact one of the sacral nerve ganglia.

HSV-1 and HSV-2 in theory can infect any (usually one) of the body's dermatome reaches.

[MoniqueLow]

Maybe you have different strain of HSV because mine is definitely evil...

Othewise thank you for explaining. I can see correlation with herpes zoster regarding the place where it hides then.

[WilsoInAus]

Remember the herpes tagline was placed upon various ailments long before their DNA was analysed. It is a pretty loose family!

Herpes Zoster is very different as it can travel in your blood to other parts of the body. HSV-1 and HSV-2 cannot do this.

[Seeker1960]

Anna Wald says HSV viremia is more common than thought. HSV can spread though out the body in the blood.

[Whyyyyy]

Well this is scary 

[Seeker1960]

https://academic.oup.com/jid/article/198/1/31/841446/Herpes-Simplex-Virus-Viremia-during-Primary

[MoniqueLow]

4 hours ago, Seeker1960 said:

https://academic.oup.com/jid/article/198/1/31/841446/Herpes-Simplex-Virus-Viremia-during-Primary

Very scary. Well, I have ghsv 1 infection and still my symptoms look like viremia. I had meningitis with initial infection (stiff neck, fever, nausea) and now I have recurrent mild fever, urethritis and generally feeling sick every day (I have also new cold sore on my lips every week - I used to have 4times a year before ghsv 1). Im afraid my  immunity can't keep the ghsv 1 virus at one location :-(